Quality improvement aims to improve processes within an organization using rapid-cycle changes, while evidence-based practice evaluates evidence to guide practices for specific populations. Research generates new generalizable knowledge through controlled studies. All three use similar methods like data collection and dissemination, but differ in purpose and rigor. Quality improvement focuses on internal improvement, evidence-based practice guides specific populations, and research creates broader knowledge. Hospitals should understand the distinctions to facilitate distinct yet collaborative initiatives in quality improvement, evidence-based practice, and research.