Differntial leucocytes functions
- 1. DIFFERNTIAL LEUCOCYTES FUNCTIONS Dr. Mrs, Minakshi Randive . Professor and Head.Kriyasharir. Tilak Ayurved Mahavidyalaya, Pune.
- 2. BASOPHIL
- 3. BASOPHILS Liberate histamine , Heparine and Serotonin . Heparine – prevents blood clotting and also removes fat particles from blood after fatty meals . Basophils collect where allergic reactions are taking place. Eg . Lung in Ashtama . Release histamine , serotonin, bradykinine , slow reacting substance .
- 4. BASOPHILS These promote and intensify the inflammatory reactions , and are involved in immediate hypersensitivity reactions . Eosinophils and Basophils act balancing each other.
- 5. MONOCYTE
- 6. MONOCYTE
- 7. MONOCYTE Tissue Macrophages. Migrate towards chemotactic stimuli and engulf and kill Bacteria . Over 100 chemicals are secreted . Bactericidal in nature . They also contain lipases which dissolve the lipid coating of bacteria like T. B. and Leprosy .
- 8. MONOCYTES Each Macrophage kills about 100 bacteria before itself is killed . Macrophages pass partly digested antigens of organisms directly to T and B cells .
- 9. NEUTROPHIL
- 10. NEUTROPHILS First to arrive at site of invasion along with Tissue macrophage . Bacterial toxins, kinins from damaged tissues ect. attract more cells to the site by chemoattraction . The bacteria are made more tasty by coating of IgG s . The Bacteria are engulfed by the process of Endocytosis
- 11. NEUTROPHILS The Granules contains – Lysozymes , proteases , and myeloperoxidases . Defensins ( Proteins ) punch holes in the bacterial membranes . Oxidants group – superoxide , hypochlorite , hydroxyl , halide , and hydrogen peroxide - kill the bacteria with in the seconds .
- 12. NEUTROPHIL Each Neutrophil can kill 8 to 10 bacteria before itself is killed . Neutrophils also release Leukotrines, prostaglandins , thromboxanes that causes reactions like inflammation – vasodilation ,hyperemia ,edema , redness, and pain .
- 13. LYMPHOCYTE
- 14. LYMPHOCYTES Three types T Lymphocytes , B Lymphocytes , Non T Non B Lymphocytes .
- 15. EOSINOPHIL
- 16. EOSINOPHILS Present in large number in the Mucosa of Lungs , gastrointestinal tract and urinary tract . Mucosal immunity . Antiallergic role – releases enzymes histaminase , leukotriene c4 ,arylsulphatase . neutralises effects of histamine and other allergic agents .
- 17. EOSINOPHILS Phagocytic function – weak phagocytic . Destroy antigen antibody complex . Antiparasitic action – effective against large Parasites . Eg. Larvae of Trichinosis , schistosomiasis . These cells attach themselves to the parasites and release hydrolytic enzymes.
- 18. BIBLIOGRAPHY Practical physiology by C.L.Ghai Text book of Physiology BY Gyton &Hall