This document is a research dissertation submitted by Joy Sixholo to the Gordon Institute of Business Science, University of Pretoria in partial fulfilment of an MBA degree. The dissertation analyses the entrepreneurial intentions of academic researchers in South Africa to create spinoffs from their research. It consists of a quantitative analysis of the determinants of entrepreneurial intentions among researchers in South African higher education institutions and science councils. The study aims to measure entrepreneurial intentions, identify factors associated with higher intentions, and compare intentions between researchers in technical and non-technical fields. A survey was conducted and data was analysed using regression to achieve the research aims.