This dissertation examines the economics of plantation slavery in the United States between the 17th-19th centuries. A literature review methodology is used due to difficulties analyzing agricultural data from slave and free states. The literature is mixed, with some arguing slavery lacked efficiency and hindered economic development through soil depletion and lack of specialization. However, large plantations remained profitable, though profits primarily benefited wealthy owners. Abolishing slavery may have encouraged a more motivated workforce and greater investment, benefiting all. Key debates center around comparing slave and free agriculture, slavery's impact on non-slaveholding whites, and the post-Civil War economic exposure of the South.