This document provides instructions for using eQUEST, an energy analysis software, in both schematic and design development modes. It summarizes the key differences and capabilities in each mode. The schematic mode allows for single floor footprint buildings with up to two HVAC systems per building. The design development mode permits multiple floor footprints and HVAC systems. It also describes how to specify building envelope constructions, windows, schedules, and perform daylighting analysis in both the schematic and design development modes.