Effersoda Bulletin for usage and formulation
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Effer-soda® surface modification enhances the stability of effervescent formulations by converting sodium bicarbonate to sodium carbonate, preventing premature effervescence. It offers improved compaction, excellent flow properties, and lower product failures compared to traditional sodium bicarbonate, making it suitable for direct compression and sachet formulations. Additionally, its manufacturing adheres to CGMP guidelines, supporting advanced pharmaceutical applications while reducing costs related to humidity control and protective packaging.
Effersoda Bulletin for usage and formulation
- 1. Effer-Soda® Surface Modification Provides Protection Tech Bulletin Sodium bicarbonate is a primary ingredient in effervescent tablets and powders. Together with an acid, such as citric acid or tartaric acid, sodium bicarbonate reacts in the presence of water to produce carbon dioxide. Consequently, the major disadvantage of sodium bicarbonate is that, in the presence of minute amounts of moisture and acid, it immediately effervesces. This reactivity can lead to formulation instability and premature effervescence in storage. Also, additional processing steps to pre-dry the powder along with special equipment and processing conditions are often required during manufacturing to avoid premature effervescence. This issue can be resolved using Effer-Soda, which is pretreated to provide enhanced stability in effervescent formulations. This is achieved by converting the appropriate amount of sodium bicarbonate to sodium carbonate. The converted sodium carbonate acts as a desiccant skin, preventing premature effervescence. Making a Difference Better Compaction and Excellent Flow Properties Effer-Soda is ideal for direct compression and sachet formulations compared to sodium bicarbonate. It has better compaction, allowing for less binder, resulting in an exceptional effervescent tablet. With a superior Carr's Index, Effer-Soda has an excellent flow compared to sodium bicarbonate. In both effervescent tablets and effervescent sachets, each particle must be surface modified to avoid premature effervescence. The Effer-Soda manufacturing process ensures that each particle of sodium bicarbonate is surface modified with sodium carbonate. 0 10 20 30 40 50 60 70 80 90 100 5 10 15 20 25 30 35 Tablet Hardness (kN) Compression Force (kN) Compaction Comparison Effer-Soda 12 Sodium Carbonate Sodium Bicarbonate Figure 1: Effer-Soda is More Highly Compactable Than Sodium Carbonate or Sodium Bicarbonate Alone
- 2. Effer-Soda® Making a Difference Making a Difference in Effervescent Formulations Effer-Soda provides the effervescence desired by your customers while lowering product failures from premature effervescence. By reducing the need for costly humidity control during manufacture and expensive protective packaging, Effer-Soda can help drive productivity and profitability. SPI Pharma's focus on the pharmaceutical industry means Effer-Soda is manufactured under cGMP guidelines, it has a Type IV US DMF to support the most advanced pharmaceutical applications. Benefits of Effer-Soda Better Compaction Less Binder Required Lower Product Failures Excellent Flow Order# SPI-EXC-EFF-0900-07201900 07-2019 | All rights reserved © 2019 SPI Pharma All information and statements given in this brochure are believed to be accurate at the time of publication. However, neither SPI Pharma nor any of their affiliates make any representations or warranty with respect thereto, including, but not limit to, any results obtained in the processing of the products by customers or any third party. All information and statements are intended for persons having the required skill and know-how and do not relieve the customer or user from verifying the suitability of information and statements given for a specific purpose prior to use of products. It is entirely the obligation of the costumer or user to comply with applicable laws and regulations, and also with all patent or other intellectual property rights of third parties. SPI PHARMA EXPRESSLY DISCLAIMS ANY REPRESENTATIONS OR WARRANTIES OF ANY KIND. WHETHER EXPRESS OR IMPLIED, AS TO THE ACCURACY, CURRENCY, COMPLETENESS AND/OR THE MERCHANTABILTY OR FITNESS FOR A PARTICULAR PURPOSE OF ANY INFORMATION CONTAINED IN THIS BROCHURE AND/OR ANY PRODUCT DESCRIBED OR PROMOTED IN THIS BROCHURE, INCLUDING WARRANTIES WITH RESPECT TO INFRINGEMENT OF ANY PATENT, COPYRIGHT, OR OTHER RIGHTS OF A THIRD PARTY. We reserve the right to change product specification and not specified properties of the products without prior notice. www.spipharma.com salesinfo@spipharma.com SPI Pharma @spipharma SPI Pharma @spipharma_real