Efruzhu cancer 9.
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This document discusses the "EFRUZHU CANCER (CARCİNOGENESİS) THEORY" regarding activator-repressor proteins and CPG island methylations. During normal cell transcription and expression, activator proteins are needed, but after neoplastic transformation, promoter regions become hypermethylated and repressor proteins prevent transcription and expression. In contrast, mutated genes can be transcriptionally expressed through activator proteins binding to hypomethylated promoter regions. Abnormal signaling via mutated receptors and signaling pathways (involving nitric oxide, guanilate cyclase, cyclic monophosphate, and calcium mobilization) allow foreign DNA or mutated genes to dominate. However, normal DNA sequences
Efruzhu cancer 9.
- 1. “EFRUZHU CANCER (CARCİNOGENESİS) THEORY” ACTİVATOR-REPPRESSOR PROTEİNS AND CPG İSLANDS METHYLATİONS. DETAİLED COMMENTS 9. NORMAL DNA SEQUENCE GENES TRANSCRİPTİON EXPRESSİON NEED ACTİVATOR PROTEİNS. BUT AFTER NEOPLASTİC TRASFORMATİON THİS PRMOTER REGİONS GENERALLY DEPENDENCE OF ENERGY, MUTATİONS GROUP AND CHRONİC İNFAMMATİON DEGREE/LEVEL ARE HYPERMETHYLATED AND SUPPRESSOR/REPPRESSOR PROTEİN SHOULD NOT PERMİT TO TRANSCRİPTİON EXPRESSİON.ON THE CONTRARY MUTATİONS GROUP İDENTİTY SEQUENCE GENES TRANSCRİPTİON EXPRESİON DOMİNANTLY POSSİBLE BY ACTİVATOR PROTEİNS İN THE PROMOTER REGİON TO BE HYPOMETHYLATED.LİGAND SİGNALİNG FROM OUTSİDE VİA MUTATİONAL RECEPTOR,ABERRANT SİGNALİNG PATHWAYS(NİTRİC OXİDE-GUANİLATE CYCLASE-CYCLİC MONO PHOSPHATE+CALCİUM MOBİLİSATİON İNFLUX AND STORES) FOREİGN DNA =MUTATİONS GROUP İDENTİTY DOMİNANT. BUT NORMAL DNA SEQUENCE COULD NOT POSSİBLE TRANSCİPTİON EXPRESSİON BECAUSE NOT ENOUGH ENERGY ATP THAT NEED PHOSPHORİLATİON VERY İMPORTANT COULD BECOME ACTİVE MOLECULES COMFORMATİONAL CHANGİNG AND NORMAL SİGNALİNG PATHWAYS VİA ADENİLATE CYCLASE- CYCLİC ADENOSİNE MONOPHOSPHATE SHOULD NOT WORKS AS YİELD/OUTPUT.VİRUS İS USİNG THE NORMAL CELL AS MACHİNERY AND CLONED=TRANSGENE İT, JUST LİKE MUTATİONS
- 2. RECEPTORSABERRANT SİGNALİNG PATHWAYS AND MUTATİONS GROUP İDENTİTY İS USİNG THE NORMAL CELL AS MACHİNERY.