The document outlines five keys to improve research costing and pricing in low- and middle-income countries, providing guidance for various stakeholders including institutional leaders and funders. It discusses challenges faced by research institutions in securing funding, such as minimal local investment and constrained research systems, and emphasizes the importance of transparency and capacity building in financial management. The latest edition highlights key concepts and offers practical tips to enhance cooperation between research institutions and funders, ultimately aiming to ensure sustainability and the effective recovery of research costs.