Expanding a Product Portfolio Without
 Cannibalizing an Established Brand




                Best Practices, LLC
         Strategic Benchmarking Research



                             1
               Copyright © Best Practices®, LLC
Research Objective & Key Topic Areas
Best Practices, LLC conducted this research to identify successful strategies and practices that can
be used by biopharmaceutical managers and executives to maximize the potential of multi-drug
portfolios or franchises.


      Study Objective & Methodology                                              Key Topics Covered
   Objective:                                                           Effective methods of differentiating
                                                                        multiple brands
   This benchmarking study was designed to
                                                                        Positioning strategies that minimize
   identify effective strategies and tactics for                        product cannibalization
   marketing multiple brands for the same                               Operational changes that drive success
   indication or area of use.                                           when introducing a new brand into a
                                                                        product family
   Special attention was given to strategies for
                                                                        Positive & negative impacts of introducing
   managing resources and for avoiding or                               a new brand
   controlling product cannibalization.                                 New product’s share of the combined
                                                                        marketing spend during first three years
   Methodology:                                                         both are marketed
   Best Practices, LLC used on online survey                            Marketing mix for new & legacy products
   instrument to collect quantitative data.                             Marketing activities that drive continuing
   Research analysts also conducted in-depth                            success for legacy brand
   interviews to collect executive insights and                         Best indicators of marketing effectiveness
   harvest best practices and lessons learned.                          Pitfalls, failure points and best practices
                                                            2
                                              Copyright © Best Practices®, LLC
Universe of Learning: Companies Participating in Study
Participants in this benchmarking research included 28 respondents at 22 leading pharmaceutical,
biotech and medical device companies. Eighty-six percent of respondents are U.S.-based. Others
are based in Mexico, India, South Africa and the Middle East.

                                             Participants
                                            Survey Only




 Participating companies include: Abbott, Alcon, Amgen, Baxter, Boehringer Ingelheim, CardioDynamics,
 Centocor Ortho Biotech, Elixir, Genzyme, Lumenis, MEDRAD, Merck, Micro Labs, Monogram Biosciences,
 Novo Nordisk, Pfizer, Schering-Plough, Shire, Solvay, Teva Neuroscience, Wyeth and Xanodyne. Participants
 also referenced past experience at Eli Lilly, Roche, Bristol-Myers Squibb, Genentech & sanofi-aventis.
                                                       3
                                         Copyright © Best Practices®, LLC
Selected Key Findings & Observations
The following findings emerged from this benchmark study.



 1.   Benefits of New Brand: In all, 96% of benchmark participants realized benefits from introducing
      a new brand where they already had a legacy product. Top among those benefits were market
      leadership, expanded market share and improved reputation with physicians and specialists.

 2.   Negative Impacts: Just over half the participants experienced negative impacts in introducing a
      new brand for the same indication or area of use as a legacy brand. The most common of those
      was creating product confusion among internal and external stakeholders.

 3.   Minimizing Cannibalization: Benchmark partners successfully use more than a dozen different
      strategies to control or minimize product cannibalization. Targeting different patient subtypes and
      aligning with thought leaders are viewed as the most effective of these.

 4.   Franchise Approach: More benchmark participants (73%) have successfully promoted their
      products together as a franchise than independently as separate brands (65%). Products that
      have complementary treatments lend themselves to franchise marketing, while those treating
      clearly different patient types are suited to marketing as independent brands.

 5.   Differentiators: Product efficacy is the attribute that benchmark partners most often find effective
      for differentiating multiple brands for the same indication or area of use. Nearly two-thirds of
      participants rated efficacy among their Top Three differentiators.

                                                        4
                                          Copyright © Best Practices®, LLC
Efficacy & Delivery Method Are Top Product Differentiators
Efficacy and delivery method head the “Top 3” list of most effective product differentiators for more
than half the benchmark participants. Frequency of use is also among the top three for 36% of
respondents.

   Q. Which three of the following options are the most effective for differentiating two or more brands
             within one company for the same indication or area of use? (Check only three.)
                                  Top Three Product Differentiators

                   Efficacy                                                     64%

          Delivery method                                           50%

          Frequency of use                              36%

                      Price                         32%

               Ease of use                       29%
               Compliance               18%

          Health outcomes               18%                             Other Top 3: Segmentation (including
                     Safety           14%                               audience type, customer type, identifying
                                                                        unique patient types for each brand (2),
             Quality of life   4%                                       patient-specific needs, efficacy or safety
                                                                        in patient population); Service & Support (2);
                     Other                          32%
                                                                        Positioning Statement.
 (N=28)
                                  % Respondents

                                                       5
                                         Copyright © Best Practices®, LLC
Multiple-Brand Marketing Spurs Many Operational Changes
Both the Sales and Marketing organizations undergo changes to accommodate introduction of a new
brand in an area where the company already has an established brand. At a majority of companies,
Sales adds training and revises incentives, while Marketing adds and shifts resources.

 Q. What operational changes did your organization undergo in order to effectively manage more than one
 brand for a single indication or area of use when the new product was introduced? (Choose all that apply.)
                      Operational Changes Resulting New Product Introduction

                  Shifted resources from older product to
                                                                                                    79%
                             marketing for newer product

                           Revised sales force incentives                                          75%

             Added new marketing funds for new product                                        68%

               Increased portfolio management activities                                      68%

                        Revised/ expanded sales training                                     64%
                                                                                                   Additional Changes=
          Realigned sales force/ Changed sales territories                             46%
                                                                                                   • Educational activities
            Revised sales coverage plan to accommodate                                               increased & shifted
                                                                                 29%
                              more people and products
                                                                                                   • Structure changed to
                               Expanded sales force size                         29%                 support portfolio
                                                                                                     objectives over
 (N=28)                                                                                              individual brand
                                                              % Respondents

                                                            6
                                              Copyright © Best Practices®, LLC
Newer Brand Receives Larger Share of Marketing Spend
The new brand typically receives just over two-thirds of the combined new and legacy product
marketing budget during its first year on market. The proportion declines slightly, relative to the
legacy product, over the course of the first three years both brands are marketed.

   Q. What percentage of the combined marketing spend (for the new and existing brands) should be
       allocated for the newer product during the first three years that both are on the market?

                                       Average Percentage of Combined Marketing Spend Allocated to Newer Product

                                        100%
                                                                                                          95%
                                                                                 90%
     % Marketing Spend for New Brand




                                                        85%
                                         80%                                                                       High
                                                        67%
                                                                                 64%
                                                                                                          61%      Average
                                         60%                                                                       (Mean)

                                                                                                                   Low
                                         40%

                                                                                 25%
                                         20%            20%                                               20%


                                          0%
(N=28)
                                                   Year ONE            Year TWO                      Year THREE
                                                                                7
                                                                  Copyright © Best Practices®, LLC
Ten Steps to Excellence in Multiple-Brand Marketing
Best Practices, LLC research identified a series of 10 critical steps that lead to excellence in
marketing multiple pharmaceutical products for the same indication or area of use.



                                            10. Plan for   1. Take a
                                           migration to    franchise-centric
                                        newer brand to     approach           2. Clearly
                              9. Price   retain patients   to managing      differentiate
                            products to     after patent   the brands
                         reflect values                                   the products--
                                              expiration                 both from each
                        of individual
                        customer segments                              other & from the
                                                      Multiple        competition
                    8. Align Sales                   Brand
                   to brand goals with                                        3. Align each brand
                   appropriate incentives
                                                   Marketing                  with distinct customer
                   & clear positioning             Excellence                 & patient segments
                                                                      4. Conduct
                          7. Provide sufficient                         situation analysis
                        sales & marketing                                to craft marketing plan
                                                  6. Align    5. Set        that best reflects
                        resources to new       marketing      realistic
                         brand to enable                                      brand & franchise
                           its growth       mix to reflect    goals &            opportunities
                                            market entry      objectives
                                     position & strength      for product sales
                                             of franchise     & adoption rates
                                                  offering

                                                           8
                                             Copyright © Best Practices®, LLC
Pitfalls to Avoid

 Key pitfalls identified by the benchmark class in surveys and interviews are:




       Insufficient buy-in/ cooperation from the sales force

       Inadequate customer/patient segmentation

       Failure to clearly differentiate/position individual products and their values

       Unrealistic product goals

       Lack of effective pricing strategy

       Internal competition for limited resources

       Poor thought leader alignment

       Insufficient investment in the new brand

       Failure to align thought leaders

       Insufficient sales force training



                                                         9
                                           Copyright © Best Practices®, LLC
Best Practices – Fulltext Responses, 1
   Key best practices identified by the benchmark class are:




                                                                   Best Practices
                  Position clearly on customer value measures (price and/or features)
                  Identify key points of differentiating the new product and focus on just a few areas supporting those areas of
                   differentiation with additional clinical work
                  Clearly articulate the positioning and key differentiation points of new, old and competitor products
Provide           Use case studies to develop patient types that paint a picture in the physician,s mind as to where to use each brand
clear
                  Some similarities in product branding, yet clear differentiation in product value
product
differentiation   Pilot newer product with thought leaders to validate value points to effectively distinguish vs, older product
& unique          Make sure MDs understand where to use each product for maximum patient benefit
positioning       Make the indications as different as possible
for each
                  Differentiate product features by market segment
brand
                  Ensure speakers/champions have precise messaging on how & when to use each brand. Use case studies.
                  Optimize portfolio positioning
                  Products must have a distinct point of differentiation
                  Differentiated marketing mix
                  Positioning brands to be able to complement each other/clear differentiation
                  Develop product differentiation strategy before late-stage clinical trials begin
                  Clear differentiation between the two products
                                                                  10
                                                    Copyright © Best Practices®, LLC
About Best Practices, LLC
We are a research and consulting firm that conducts work based on the simple, yet
profound principle that organizations can chart a course to superior economic
performance by studying the best business practices, operating tactics and winning
strategies of world-class companies.




                        Best Practices, LLC
                         6350 Quadrangle Drive, Suite 200,
                               Chapel Hill, NC 27517
                             www3.best-in-class.com
                              For more information contact:

                                     Martha Haswell
                                 Senior Research Analyst
                                      919.767.9249
                             mhaswell@best-in-class.com




                                                11
                                  Copyright © Best Practices®, LLC

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Expanding a Product Portfolio Without Cannibalizing an Established Brand Report Summary

  • 1. Expanding a Product Portfolio Without Cannibalizing an Established Brand Best Practices, LLC Strategic Benchmarking Research 1 Copyright © Best Practices®, LLC
  • 2. Research Objective & Key Topic Areas Best Practices, LLC conducted this research to identify successful strategies and practices that can be used by biopharmaceutical managers and executives to maximize the potential of multi-drug portfolios or franchises. Study Objective & Methodology Key Topics Covered Objective: Effective methods of differentiating multiple brands This benchmarking study was designed to Positioning strategies that minimize identify effective strategies and tactics for product cannibalization marketing multiple brands for the same Operational changes that drive success indication or area of use. when introducing a new brand into a product family Special attention was given to strategies for Positive & negative impacts of introducing managing resources and for avoiding or a new brand controlling product cannibalization. New product’s share of the combined marketing spend during first three years Methodology: both are marketed Best Practices, LLC used on online survey Marketing mix for new & legacy products instrument to collect quantitative data. Marketing activities that drive continuing Research analysts also conducted in-depth success for legacy brand interviews to collect executive insights and Best indicators of marketing effectiveness harvest best practices and lessons learned. Pitfalls, failure points and best practices 2 Copyright © Best Practices®, LLC
  • 3. Universe of Learning: Companies Participating in Study Participants in this benchmarking research included 28 respondents at 22 leading pharmaceutical, biotech and medical device companies. Eighty-six percent of respondents are U.S.-based. Others are based in Mexico, India, South Africa and the Middle East. Participants Survey Only Participating companies include: Abbott, Alcon, Amgen, Baxter, Boehringer Ingelheim, CardioDynamics, Centocor Ortho Biotech, Elixir, Genzyme, Lumenis, MEDRAD, Merck, Micro Labs, Monogram Biosciences, Novo Nordisk, Pfizer, Schering-Plough, Shire, Solvay, Teva Neuroscience, Wyeth and Xanodyne. Participants also referenced past experience at Eli Lilly, Roche, Bristol-Myers Squibb, Genentech & sanofi-aventis. 3 Copyright © Best Practices®, LLC
  • 4. Selected Key Findings & Observations The following findings emerged from this benchmark study. 1. Benefits of New Brand: In all, 96% of benchmark participants realized benefits from introducing a new brand where they already had a legacy product. Top among those benefits were market leadership, expanded market share and improved reputation with physicians and specialists. 2. Negative Impacts: Just over half the participants experienced negative impacts in introducing a new brand for the same indication or area of use as a legacy brand. The most common of those was creating product confusion among internal and external stakeholders. 3. Minimizing Cannibalization: Benchmark partners successfully use more than a dozen different strategies to control or minimize product cannibalization. Targeting different patient subtypes and aligning with thought leaders are viewed as the most effective of these. 4. Franchise Approach: More benchmark participants (73%) have successfully promoted their products together as a franchise than independently as separate brands (65%). Products that have complementary treatments lend themselves to franchise marketing, while those treating clearly different patient types are suited to marketing as independent brands. 5. Differentiators: Product efficacy is the attribute that benchmark partners most often find effective for differentiating multiple brands for the same indication or area of use. Nearly two-thirds of participants rated efficacy among their Top Three differentiators. 4 Copyright © Best Practices®, LLC
  • 5. Efficacy & Delivery Method Are Top Product Differentiators Efficacy and delivery method head the “Top 3” list of most effective product differentiators for more than half the benchmark participants. Frequency of use is also among the top three for 36% of respondents. Q. Which three of the following options are the most effective for differentiating two or more brands within one company for the same indication or area of use? (Check only three.) Top Three Product Differentiators Efficacy 64% Delivery method 50% Frequency of use 36% Price 32% Ease of use 29% Compliance 18% Health outcomes 18% Other Top 3: Segmentation (including Safety 14% audience type, customer type, identifying unique patient types for each brand (2), Quality of life 4% patient-specific needs, efficacy or safety in patient population); Service & Support (2); Other 32% Positioning Statement. (N=28) % Respondents 5 Copyright © Best Practices®, LLC
  • 6. Multiple-Brand Marketing Spurs Many Operational Changes Both the Sales and Marketing organizations undergo changes to accommodate introduction of a new brand in an area where the company already has an established brand. At a majority of companies, Sales adds training and revises incentives, while Marketing adds and shifts resources. Q. What operational changes did your organization undergo in order to effectively manage more than one brand for a single indication or area of use when the new product was introduced? (Choose all that apply.) Operational Changes Resulting New Product Introduction Shifted resources from older product to 79% marketing for newer product Revised sales force incentives 75% Added new marketing funds for new product 68% Increased portfolio management activities 68% Revised/ expanded sales training 64% Additional Changes= Realigned sales force/ Changed sales territories 46% • Educational activities Revised sales coverage plan to accommodate increased & shifted 29% more people and products • Structure changed to Expanded sales force size 29% support portfolio objectives over (N=28) individual brand % Respondents 6 Copyright © Best Practices®, LLC
  • 7. Newer Brand Receives Larger Share of Marketing Spend The new brand typically receives just over two-thirds of the combined new and legacy product marketing budget during its first year on market. The proportion declines slightly, relative to the legacy product, over the course of the first three years both brands are marketed. Q. What percentage of the combined marketing spend (for the new and existing brands) should be allocated for the newer product during the first three years that both are on the market? Average Percentage of Combined Marketing Spend Allocated to Newer Product 100% 95% 90% % Marketing Spend for New Brand 85% 80% High 67% 64% 61% Average 60% (Mean) Low 40% 25% 20% 20% 20% 0% (N=28) Year ONE Year TWO Year THREE 7 Copyright © Best Practices®, LLC
  • 8. Ten Steps to Excellence in Multiple-Brand Marketing Best Practices, LLC research identified a series of 10 critical steps that lead to excellence in marketing multiple pharmaceutical products for the same indication or area of use. 10. Plan for 1. Take a migration to franchise-centric newer brand to approach 2. Clearly 9. Price retain patients to managing differentiate products to after patent the brands reflect values the products-- expiration both from each of individual customer segments other & from the Multiple competition 8. Align Sales Brand to brand goals with 3. Align each brand appropriate incentives Marketing with distinct customer & clear positioning Excellence & patient segments 4. Conduct 7. Provide sufficient situation analysis sales & marketing to craft marketing plan 6. Align 5. Set that best reflects resources to new marketing realistic brand to enable brand & franchise its growth mix to reflect goals & opportunities market entry objectives position & strength for product sales of franchise & adoption rates offering 8 Copyright © Best Practices®, LLC
  • 9. Pitfalls to Avoid Key pitfalls identified by the benchmark class in surveys and interviews are: Insufficient buy-in/ cooperation from the sales force Inadequate customer/patient segmentation Failure to clearly differentiate/position individual products and their values Unrealistic product goals Lack of effective pricing strategy Internal competition for limited resources Poor thought leader alignment Insufficient investment in the new brand Failure to align thought leaders Insufficient sales force training 9 Copyright © Best Practices®, LLC
  • 10. Best Practices – Fulltext Responses, 1 Key best practices identified by the benchmark class are: Best Practices Position clearly on customer value measures (price and/or features) Identify key points of differentiating the new product and focus on just a few areas supporting those areas of differentiation with additional clinical work Clearly articulate the positioning and key differentiation points of new, old and competitor products Provide Use case studies to develop patient types that paint a picture in the physician,s mind as to where to use each brand clear Some similarities in product branding, yet clear differentiation in product value product differentiation Pilot newer product with thought leaders to validate value points to effectively distinguish vs, older product & unique Make sure MDs understand where to use each product for maximum patient benefit positioning Make the indications as different as possible for each Differentiate product features by market segment brand Ensure speakers/champions have precise messaging on how & when to use each brand. Use case studies. Optimize portfolio positioning Products must have a distinct point of differentiation Differentiated marketing mix Positioning brands to be able to complement each other/clear differentiation Develop product differentiation strategy before late-stage clinical trials begin Clear differentiation between the two products 10 Copyright © Best Practices®, LLC
  • 11. About Best Practices, LLC We are a research and consulting firm that conducts work based on the simple, yet profound principle that organizations can chart a course to superior economic performance by studying the best business practices, operating tactics and winning strategies of world-class companies. Best Practices, LLC 6350 Quadrangle Drive, Suite 200, Chapel Hill, NC 27517 www3.best-in-class.com For more information contact: Martha Haswell Senior Research Analyst 919.767.9249 mhaswell@best-in-class.com 11 Copyright © Best Practices®, LLC