Explanation of X-Linked inheritance
- 1. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre Passing on genetic information from parents to children An explanation of X- linked inheritance
- 2. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre • Here are some PowerPoint teaching slides which demonstrate the transmission of an x-linked inherited condition from parent to child; please feel free to use these within your teaching • Some parts of the animations run automatically; others require a mouse click • Most slides have notes with further information
- 3. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre Hundreds of genes are located on each chromosome (The dark bands on the chromosomes are due to a special staining technique and are not genes as these are too small to see) The 46 human chromosomes seen down the microscope
- 4. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre The 46 human chromosomes arranged in their 23 pairs
- 5. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre The 46 human chromosomes arranged in their 23 pairs Sex chromosomes of a male
- 6. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre The 46 human chromosomes arranged in their 23 pairs Sex chromosomes of a male female
- 7. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre Males X chromosome Y chromosome Females X chromosome Position of particular gene
- 8. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre X-linked inheritance where the mother is a carrier for an X-linked recessive condition
- 9. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre Males X chromosome Y chromosome Females X chromosome Altered gene Male with an X- linked recessive condition Altered geneUsual gene Female who is a carrier for an X-linked recessive condition
- 10. Parents Sperm/Eggs At conception X-linked recessive inheritance where the mother is a carrier Father Mother X Y XX Daughter Daughter Son Son
- 11. Parents Sperm/Eggs X-linked recessive inheritance where the mother is a carrier Father Mother X Y XX Female, does not have the condition, non-carrier Female, carrier for the condition Male, does not have the condition Male, has the condition
- 12. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre X-linked inheritance where the father has an X-linked recessive condition
- 13. Parents Father Mother X Y XX Daughter Daughter Son Son X-linked recessive inheritance where the father has an X-linked condition Sperm/Eggs At conception
- 14. Parents Father Mother X-linked recessive inheritance where the father has an X-linked condition Sperm/Eggs Female, carrier for the condition Male, does not have the condition
- 15. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre X-linked dominant inheritance Only a few disorders are known to be inherited in an X- linked dominant manner.
- 16. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre X-linked dominant inheritance where the mother has the condition
- 17. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre Males X chromosome Y chromosome Females X chromosome Altered gene Male with an X- linked dominant condition Usual geneAltered gene Female who has an X-linked dominant condition
- 18. Parents At conception Father Mother X Y XX Daughter Daughter Son Son Has condition Unaffected Sperm/Eggs X-linked dominant inheritance where the mother has the condition
- 19. Parents At conception Father Mother X Y XX Daughter with condition Daughter without condition Son with condition Son without condition Has condition Unaffected Sperm/Eggs X-linked dominant inheritance where the mother has the X-linked condition
- 20. Parents Father Mother Daughter with condition Daughter without condition Son without condition Has condition Unaffected X-linked dominant inheritance where the mother has the X-linked condition Son with condition X-linked dominant conditions may be so severe that males with the condition do not survive
- 21. Parents Father Mother Daughter with condition Daughter without condition Son without condition Has condition Unaffected X-linked dominant inheritance where the mother has the X-linked condition So fewer males than expected may be seen in the children of a mother who has an X-linked dominant condition
- 22. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre This animation is part of a series describing modes of inheritance To access these and other resources for teaching and learning genetics, please visit: www.geneticseducation.nhs.uk