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Expo Day
2CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
PRESENTED TO
SharpBrains
November 19, 2015
Dr. Randy McIntosh
Vice President, Research
3CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
THE GLOBAL CHALLENGE
•  47.5M people with dementia now
•  1.1 billion more seniors globally by
2050; 135.5M of them will have
dementia
•  Dementia leading cause of disability
among Canadian seniors
4CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
NO CURE, BUT HOPE
•  Research
• Lifestyle strategies
• Early diagnosis/intervention
• Quality of life
5CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
OPPORTUNITY
•  Senior care and brain health markets
• Senior care projected worth $319 billion in US
by 2016
• Brain health applications, software, biometrics
projected growth to between $4 and 10 billion by
2020
6CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
BARRIERS TO INNOVATION
Lack of:
•  Focus
•  Test environment
•  Evidence
•  Supporting resources
•  Lead customer
7CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
OPPORTUNITY
Senior care and brain health markets
•  Senior care projected worth $319
billion in US by 2016
•  Brain health applications, software,
biometrics projected growth to
between $4 and 10 billion by 2020
8CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
Canadian Centre for Aging and Brain Health
Innovation (CC-ABHI)
VISION
A world in which people can age in the setting of their choice,
maintaining their cognitive, emotional and physical well-being, and
independence as long as possible
MISSION
To accelerate: development, validation, commercialization,
dissemination and adoption of innovative products, services and
best practices to support brain health and aging
9CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
FUNDING
Over next 5 years
•  $42M Government of Canada
•  $23.5M Government of Ontario
•  $33.1M Industry & Public Sector
•  $25M Donors
10CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
PROGRAM AREAS
DEVELOP
Innovative
Solutions
DISSEMINATE
Knowledge &
Best Practices
TEST
Products in
Real-World
Settings
CC-ABHI
11CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
DEVELOP
Solutions to enhance aging
•  Translate basic research into real-world
technologies, solutions and applications
•  Become a catalyst for commercialization of
technologies and solutions in this sector
12CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
TEST
Support companies and other innovators to
demonstrate, test and improve products and
processes targeting aging adults and the mental
or cognitive health of seniors
•  Healthcare organizations, governments,
physicians won’t invest without evidence.
•  CC-ABHI offers a population of elders and
expertise in testing methodologies and
generating evidence
13CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
DISSEMINATE
Disseminate solutions by providing
services to drive adoption and scalability
•  Innovations and knowledge offered to
all partners within CC-ABHI’s network
•  Experiential training, telemedicine, e-
learning modules ensure wide
adoption of validated solutions
14CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
COLLABORATION MODEL
15CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
INNOVATION PIPELINE
INNOVATION
16CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
PARTNERS TO DATE
17CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
Seniors Quality LEAP Initiative (SQLI)
18CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
Thank you
Dr. Randy McIntosh
Vice President, Research
rmcintosh@research.baycrest.org
19CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
Summit is on break.
(we will resume at 11:15am Pacific Time)
Privileged & Confidential
Lumos Labs, Inc.
Lumos Labs
SharpBrains Summit
19 November 2015
Glenn Morrison, PhD
LUMOS LABS, INC.
Our Mission
•  Create and validate training tools that aim to improve cognitive
abilities
•  Create and validate assessment tools to measure cognitive
performance
•  Advance the pace of cognitive science research
•  Expand the understanding of the human brain
LUMOS LABS, INC.
HCP Researcher Ecosystem
•  Includes university-based researchers, industry partners,
educators, clinicians, and study volunteers 
•  Research areas include: 
•  brain injuries and rehabilitation
•  chronic conditions
•  diseases and disorders
•  data science projects
•  education and learning
•  exercise and athletics
•  cognitive change in healthy adults
LUMOS LABS, INC.
Problem Statement for 

Brain Training Industry
➡  No clear agreement on the core elements that need to be included
in any study of CCT in order to demonstrate clear evidence of
efficacy (statistical improvement) and effectiveness (real-world
relevance)
•  ‘Stanford’ Statement
•  Statement released by The Stanford Center on
Longevity and the Berlin Max Planck Institute for
Human Development
•  Signed by 70 largely academic researchers
•  Finds that claims promoting brain games are
frequently exaggerated and at times misleading
•  Encourages continued careful research and
validation in this field
•  Open Response Letter
•  Open Letter published and signed by 127
neuroscientists, psychologists, and other experts in
the field of neural plasticity
•  Disagrees with the consensus
•  Does not agree that “there is no compelling
scientific evidence” that brain exercises “offer
consumers a scientifically grounded avenue to
reduce or reverse cognitive decline.”
•  Expressed concern that many readers of the
Stanford statement might wrongly conclude that
there is no evidence that any cognitive training
regimen can improve cognitive function
LUMOS LABS, INC.
Call to Action
•  Bring together CCT industry leaders, academics, and experts in
the field
•  Review and discuss current state of computerized cognitive
training research
•  Reach consensus on the standards for conducting adequate and
well-controlled studies to support efficacy and effectiveness
•  Publish consensus paper that those in the field can turn to for
guidance
LUMOS LABS, INC.
Open Questions for Consideration
•  What is the best control condition?
•  Active control?
•  Passive/no-contact control?
•  What is the optimal training regimen?
•  How many times/week?
•  How many weeks?
•  Requirement for booster?
•  Requirement for maintenance of effect?
•  What are the best outcomes
•  Measuring cognition
•  Computerized assessments vs pencil/paper
•  Remote vs in-clinic
•  Measuring function
•  Self-reported outcomes
•  Performance based outcomes
•  Other
LUMOS LABS, INC.
How to Get Involved
•  An Industry effort and not a Lumos/Lumosity effort
•  Currently generating list of experts to reach out to and plan for an
initial meeting in early 2016
•  Small group first in an effort to identify key principles and agree on
major themes
•  Plan for larger meeting in Q1 2016
•  Interested? Contact glenn@lumoslabs.com
LUMOS LABS, INC.
Privileged & Confidential
Lumos Labs, Inc.
70 Million Bright Minds
LUMOS LABS, INC.
Summit is on break.
(we will resume at 12pm Pacific Time)
Joan	Severson,		
President	of	Digital	Artefacts
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Summit is on break.
(we will resume at 12:45pm Pacific Time)
Alvaro Fernandez
@alvarof
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Remember the opportunity…
Improve
performance Delay
decline
…but, no one shoe fits all
AGE
PERFORMANCE
25 50 75 100
PERFORMANCE
AGE
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains
Japanese edition in 1-2 months
(Hankyu Communications)
Source: The SharpBrains Guide to Brain Fitness (second edition)
Example: Cells that fire together
wire together
Example: Don’t need to be a
car mechanic, but…
Example: Mental activity
vs. mental exercise
Source: Maguire, Woollett, & Spiers, 2006
We better start educating
users and professionals
"A stimulating, challenging resource, full of solid
information and practical tips for
improving brain health." –Kirkus Reviews
"On a personal note, I have to say I wish I had
read this awesome guide when I was much
younger.” –Scientific American
"...nice to see the new book…where all of the
relevant information is in one place." –Greater
Good Science Center at UC-Berkeley
à Amazon + Libraries
•  Getting to more readers
•  Book or another format
•  “Brain Fitness” or “Invest in your Brain”
•  Science-help vs divulgation vs self-help
•  Start or end with Jigsaw
•  Role of interviews
•  Questionnaire/ quiz?
Brainstorming
Sponsors	
Thank you
To learn more, visit sharpbrains.com

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Expo Day: Baycrest, Lumosity, BrainBaseline & SharpBrains

  • 2. 2CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION PRESENTED TO SharpBrains November 19, 2015 Dr. Randy McIntosh Vice President, Research
  • 3. 3CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION THE GLOBAL CHALLENGE •  47.5M people with dementia now •  1.1 billion more seniors globally by 2050; 135.5M of them will have dementia •  Dementia leading cause of disability among Canadian seniors
  • 4. 4CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION NO CURE, BUT HOPE •  Research • Lifestyle strategies • Early diagnosis/intervention • Quality of life
  • 5. 5CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION OPPORTUNITY •  Senior care and brain health markets • Senior care projected worth $319 billion in US by 2016 • Brain health applications, software, biometrics projected growth to between $4 and 10 billion by 2020
  • 6. 6CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION BARRIERS TO INNOVATION Lack of: •  Focus •  Test environment •  Evidence •  Supporting resources •  Lead customer
  • 7. 7CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION OPPORTUNITY Senior care and brain health markets •  Senior care projected worth $319 billion in US by 2016 •  Brain health applications, software, biometrics projected growth to between $4 and 10 billion by 2020
  • 8. 8CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION Canadian Centre for Aging and Brain Health Innovation (CC-ABHI) VISION A world in which people can age in the setting of their choice, maintaining their cognitive, emotional and physical well-being, and independence as long as possible MISSION To accelerate: development, validation, commercialization, dissemination and adoption of innovative products, services and best practices to support brain health and aging
  • 9. 9CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION FUNDING Over next 5 years •  $42M Government of Canada •  $23.5M Government of Ontario •  $33.1M Industry & Public Sector •  $25M Donors
  • 10. 10CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION PROGRAM AREAS DEVELOP Innovative Solutions DISSEMINATE Knowledge & Best Practices TEST Products in Real-World Settings CC-ABHI
  • 11. 11CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION DEVELOP Solutions to enhance aging •  Translate basic research into real-world technologies, solutions and applications •  Become a catalyst for commercialization of technologies and solutions in this sector
  • 12. 12CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION TEST Support companies and other innovators to demonstrate, test and improve products and processes targeting aging adults and the mental or cognitive health of seniors •  Healthcare organizations, governments, physicians won’t invest without evidence. •  CC-ABHI offers a population of elders and expertise in testing methodologies and generating evidence
  • 13. 13CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION DISSEMINATE Disseminate solutions by providing services to drive adoption and scalability •  Innovations and knowledge offered to all partners within CC-ABHI’s network •  Experiential training, telemedicine, e- learning modules ensure wide adoption of validated solutions
  • 14. 14CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION COLLABORATION MODEL
  • 15. 15CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION INNOVATION PIPELINE INNOVATION
  • 16. 16CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION PARTNERS TO DATE
  • 17. 17CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION Seniors Quality LEAP Initiative (SQLI)
  • 18. 18CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION Thank you Dr. Randy McIntosh Vice President, Research rmcintosh@research.baycrest.org
  • 19. 19CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION Summit is on break. (we will resume at 11:15am Pacific Time)
  • 20. Privileged & Confidential Lumos Labs, Inc. Lumos Labs SharpBrains Summit 19 November 2015 Glenn Morrison, PhD
  • 21. LUMOS LABS, INC. Our Mission •  Create and validate training tools that aim to improve cognitive abilities •  Create and validate assessment tools to measure cognitive performance •  Advance the pace of cognitive science research •  Expand the understanding of the human brain
  • 22. LUMOS LABS, INC. HCP Researcher Ecosystem •  Includes university-based researchers, industry partners, educators, clinicians, and study volunteers •  Research areas include: •  brain injuries and rehabilitation •  chronic conditions •  diseases and disorders •  data science projects •  education and learning •  exercise and athletics •  cognitive change in healthy adults
  • 23. LUMOS LABS, INC. Problem Statement for 
 Brain Training Industry ➡  No clear agreement on the core elements that need to be included in any study of CCT in order to demonstrate clear evidence of efficacy (statistical improvement) and effectiveness (real-world relevance) •  ‘Stanford’ Statement •  Statement released by The Stanford Center on Longevity and the Berlin Max Planck Institute for Human Development •  Signed by 70 largely academic researchers •  Finds that claims promoting brain games are frequently exaggerated and at times misleading •  Encourages continued careful research and validation in this field •  Open Response Letter •  Open Letter published and signed by 127 neuroscientists, psychologists, and other experts in the field of neural plasticity •  Disagrees with the consensus •  Does not agree that “there is no compelling scientific evidence” that brain exercises “offer consumers a scientifically grounded avenue to reduce or reverse cognitive decline.” •  Expressed concern that many readers of the Stanford statement might wrongly conclude that there is no evidence that any cognitive training regimen can improve cognitive function
  • 24. LUMOS LABS, INC. Call to Action •  Bring together CCT industry leaders, academics, and experts in the field •  Review and discuss current state of computerized cognitive training research •  Reach consensus on the standards for conducting adequate and well-controlled studies to support efficacy and effectiveness •  Publish consensus paper that those in the field can turn to for guidance
  • 25. LUMOS LABS, INC. Open Questions for Consideration •  What is the best control condition? •  Active control? •  Passive/no-contact control? •  What is the optimal training regimen? •  How many times/week? •  How many weeks? •  Requirement for booster? •  Requirement for maintenance of effect? •  What are the best outcomes •  Measuring cognition •  Computerized assessments vs pencil/paper •  Remote vs in-clinic •  Measuring function •  Self-reported outcomes •  Performance based outcomes •  Other
  • 26. LUMOS LABS, INC. How to Get Involved •  An Industry effort and not a Lumos/Lumosity effort •  Currently generating list of experts to reach out to and plan for an initial meeting in early 2016 •  Small group first in an effort to identify key principles and agree on major themes •  Plan for larger meeting in Q1 2016 •  Interested? Contact glenn@lumoslabs.com
  • 27. LUMOS LABS, INC. Privileged & Confidential Lumos Labs, Inc. 70 Million Bright Minds
  • 28. LUMOS LABS, INC. Summit is on break. (we will resume at 12pm Pacific Time)
  • 61. Summit is on break. (we will resume at 12:45pm Pacific Time)
  • 65. …but, no one shoe fits all AGE PERFORMANCE 25 50 75 100 PERFORMANCE AGE
  • 68. Japanese edition in 1-2 months (Hankyu Communications)
  • 69. Source: The SharpBrains Guide to Brain Fitness (second edition)
  • 70. Example: Cells that fire together wire together
  • 71. Example: Don’t need to be a car mechanic, but…
  • 72. Example: Mental activity vs. mental exercise Source: Maguire, Woollett, & Spiers, 2006
  • 73. We better start educating users and professionals
  • 74. "A stimulating, challenging resource, full of solid information and practical tips for improving brain health." –Kirkus Reviews "On a personal note, I have to say I wish I had read this awesome guide when I was much younger.” –Scientific American "...nice to see the new book…where all of the relevant information is in one place." –Greater Good Science Center at UC-Berkeley à Amazon + Libraries
  • 75. •  Getting to more readers •  Book or another format •  “Brain Fitness” or “Invest in your Brain” •  Science-help vs divulgation vs self-help •  Start or end with Jigsaw •  Role of interviews •  Questionnaire/ quiz? Brainstorming
  • 77. To learn more, visit sharpbrains.com