Extinction occurs when a species dies out completely. It has multiple causes including habitat loss, climate change, invasive species, disease, and human activities like pollution and deforestation. Small population sizes also increase the risk of extinction due to reduced genetic diversity and inbreeding. Mass extinctions have occurred periodically throughout history, including one caused by an asteroid impact 65 million years ago. Today's extinction rates are estimated to be 100-1000 times higher than background rates, primarily due to human activities. Biodiversity hotspots experience especially high rates of species loss. International efforts like the Convention on Biological Diversity aim to reduce extinction risks.