FILTRATION, THEORY OF FILTRATION, APPLICATION OF FILTRATION ,CLARIFICATION
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Filtration is a separation process used to remove solids from liquids by passing them through a porous medium, called the filter medium. The document discusses various theories, equipment, and applications of filtration in pharmaceutical processes, such as sterile product production and wastewater treatment. It also covers equations like Darcy's and Kozeny-Carman for calculating filtration rates, as well as different types of filters, including plate and frame filter presses and cartridge filters.
FILTRATION, THEORY OF FILTRATION, APPLICATION OF FILTRATION ,CLARIFICATION
- 1. FILTRATION (PHARMACEUTICAL PROCESS CHEMISTRY) Presented by: SHIKHA POPALI HARSHPAL SINGH WAHI
- 2. Definition 2 Filtration: It may be define as a process of separation of solids from a fluid by passing the same through a porous medium that retains the solids but allows the fluid to pass through. The suspension to be filtered is known as slurry. The porous medium used to retain the solids is known as filter medium. Clarification: When solid are present in very low concentration, i.e., not exceeding 1.0% w/v, the process of its separation from liquid is called clarification.
- 3. Applications of filtration 3 Production of sterile products: HEPA filters or laminar air bench Membrane filters. Production of bulk drugs Production of liquid dosage Effluents and waste water treatment
- 4. Theories of filtration 4 The flow of liquid through a filter follows the basic rules that flow of any liquid through the medium offering resistance. The rate of flow may be expressed as- Rate = driving force / resistance The rate of filtration may be expressed as volume (litres) per unit time (dv/dt). Driving force = pressure upstream – pressure downstream Resistance is not constant. It increases with an increase in the deposition of solids on the filter medium. Therefore filtration is not a steady state.
- 5. Continue…….. Fig.: Filtration process parameters. Upstream pressure, P1 The rate of flow will be greatest at the beginning of filtration process, since the resistance is minimum. After forming of filter cake, its surface acts as filter medium Powder or granule bed visualized as a bundle of capillaries Surface area Length (L) Downstream pressure, P2 Viscosity Flow rate: m3 / unit time 5 Resistance to flow is related to several factors given in fig. Resistance to movement={pressure upstream- pressure downstream}/ length of capillaries
- 6. Poiseullie’s Equation Poiseullie considered that filtration is similar to the streamline flow of liquid under pressure through capillaries. Poiseullie’s Equation is- Where, V = rate of flow, ΔP= Pressure difference across the filter, r = radius of capillary in the filter bed, L = thickness of filter cake (capillary length), 𝝶= viscosity of filtrate If the cake is composed of bulky mass of particles and the liquid flows through the interstice, then flow of liquids through these may be expressed by this equation. 6
- 7. Darcy’s Equation 7 Poiseullie's law assumes that the capillaries found in the filter are highly irregular and non-uniform. Therefore, if the length of capillary is taken as the thickness of bed, a correction factor for radius is applied so that the rate is closely approximated and simplified. The factors influencing the rate of filtration has been incorporated into an equation by Darcy, which is: Where, K = permeability coefficient of cake, m2 A = surface area of porous bed (filter medium), m2 Other terms are same as previous equation K depends on characteristics of cake, such as porosity, specific surface area and compressibility.
- 8. Kozeny-Carman (K-C) equation Kozeny-Carman equation is widely used for filtration. Where, 𝝴= porosity of cake (bed) S= specific surface area of particles comprising the cake m2 / m3 K= Kozeny constant Other terms are same as previousequations Limitations: It does not consider the fact that depth of granular bed is lesser than the actual path traversed by the fluid. 14
- 9. Classification of filtration equipment 9 Based on application of external force: filters Pressure filters Plate and frame filter press Meta filter Vacuum filters Filter leaf Centrifugal filters centrifuges
- 10. Plate and frame filter press Principle: Mechanism is surface filtration. The slurry enters the frame by pressure and flows through filter medium. The filtrate is collected on the plates and send to outlet. A number of frames and plates are used so that surface area increases and consequently large volumes of slurry can be processed simultaneously with or without washing. 10
- 11. Diagram 30
- 12. Assembly of plate and frame filter 12
- 13. Construction 13 The Filter press is made of two types of units, plate and frames. Usually made of aluminium alloy. Sometimes, these are also lacquered for protection against corrosive chemicals and made suitable for steam sterilization. Frame It contains a open space inside wherein the slurry reservoir is maintained for filtration and an inlet to receive the slurry. It is indicated by two dots in description. Slurry inlet Handle to rest on rod
- 14. 14 Frames of different thickness are available. It is selected based on the thickness of cake formed during filtration. Optimum thickness of frame should be chosen. Plate The plate has a studded or grooved surface to support the filter cloth and an outlet. It is indicated by one dot in description. Through channel Filtrate outlet Continue……
- 15. Working Working can be divided into two steps- 1. Filtration operation 2. Washing of cake (if desirable) Filtration operation 35 Frame- marked by 2 dots Plate – marked by 1 dot Plate and frame filter press, principle of filtration operation
- 16. Continue…… 16 Slurry enters the frame from the feed channel and passes through the filter medium on the surface of the plate The solid forms a filter cake and remain in the frame The thickness of the cake is half of the frame thickness, because on each side of frame filtration occurs Thus two filter cakes are formed , which meet eventually in the centre of the frame The filtrate drains between the projections of the surface of the plate and escape from the outlet As filtration proceeds, the resistance of the cake increases and filtration rate decrease At a certain point process is stopped and press is emptied and cycle is restarted
- 17. Washing operation 17 When washing of cake is also required modified plate and frame filter is used. For this purpose an additional channel is included called as washing plate and are identified by 3 dots. In the half of the washing plate, there is a connection from wash water cannel to the surface of plate. The sequence of arrangement of plates and frames can be represented by dots between 1 and 1, 2.3.2 must be arranged.
- 18. Filter leaf 18 Principle: It is an apparatus consisting of a longitudinal drainage screen covered with a filter cloth. The mechanism is surface filtration and acts as sieve or strainer. Vacuum or pressure can be applied to increase the rate of filtration. Construction: The leaf filter is consisting of a frame enclosing a drainage screen or grooved plate. The frame may be any shape circular, square or rectangular. The whole unite being covered with filter cloth. The outlet for the filtrate connects to the inside of the frame through suction.
- 19. Diagram 19
- 20. Working and uses 20 Working: Use: The filter leaf is satisfactory, if the solid content of the slurry is not high, about 5% i.e. dilute suspension. The filter leaf is immersed in the slurry Vacuum system is connected to the outlet The slurry passes through the filter cloth Finally filtrate enters the drainage canal and goes through the outlet into receiver Air is passed to flow in reverse direction which facilitates removal of cake
- 21. Metafilter Principle: Mechanism is surface filtration. In this, metal rings contain semicircular projections, which are arranged as a nest to form channels on the edges. This channel offers resistance (strainer) to the flow of solids (coarse particles). The clear liquid is collected into receiver from the top. 21
- 22. Construction 22 Metafilter consists of a series of metal rings. These are threaded so that a channel is formed on the edges. It contains a grooved drainage column on which a series of metal rings are packed. These rings are usually made up of stainless steel and have dimensions of about 15.0 mm internal diameter and 22.0 mm external diameter. Each metal ring has a number of semicircular projections (0.8 mm in thickness) on one side of surface. The projections are arranged as a nest to form channels on the edges. These rings are tightened on the drainage column with a nut. Metafilters are also known as edge filters.
- 23. Diagram 23
- 24. Working 24 Filters are placed in a vessel Slurry is pumped under pressure or occasionally by applying reduced pressure to the outlet side Slurry passes through the channels formed on the edges between the rings The clear liquid rises up and collected from the outlet into receiver
- 25. Uses 25 can be achieved by applying Metafilters can be used for- Clarification of syrups Filtration of injection solutions Clarification of insulin liquors Filtration of viscous liquids pressure.
- 26. Cartridge filter Principle: It is a thin porous membrane in which pre filter and membrane filter are combined in a single unit. The filtration action is mainly sieve like and particles are retained on the surface. Construction: It has cylindrical configuration made with disposable or changeable filter media. Made up of either plastic or metal. Consist of two membrane filters (sieve like) made of polypropylene: pre filter and actual filter for filtration. A protective layer surrounds them. The cartridge are housed in a holder and a number of cartridges can be placed in a same housing. The housing is closed with the lid. Housing has provisions for slurry inlet and outlets. 60
- 27. Diagram 27
- 28. Working and uses 28 Working: Uses: Particularly useful for preparation of particulate free solutions for parenterals and ophthalmic uses. This filter holder will process 1000 – 15000 litres of sterile solution per hour. Slurry is pumped into cartridge holder It passes through cartridge filter unit by straining The clear liquid passes through the centre Moves up to collect through outlet
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