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IAEA
International Atomic Energy Agency
Slide set of 44 slides based on the chapter authored by
K. H. Ng and D. R. Dance
of the IAEA publication (ISBN 978-92-0-131010-1):
Diagnostic Radiology Physics:
A Handbook for Teachers and Students
Objective:
To familiarize students with basic principles of atomic and nuclear
Physics used in diagnostic radiology
Chapter 1: Fundamentals of Atomic and
Nuclear Physics
Slide set prepared
by E.Okuno (S. Paulo, Brazil,
Institute of Physics of S. Paulo
University)
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 2
Chapter 1. TABLE OF CONTENTS
1.1. Introduction
1.2. Classification of radiation
1.3. Atomic and nuclear structure
1.4. X rays
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 3
1.1 INTRODUCTION
is fundamental to the understanding of the physics of
medical imaging and radiation protection. This, the
first chapter of the Handbook, summarises those
aspects of these areas which, being part of the
foundation of modern physics, underpin the remainder
of the book
• structure of the atom
• elementary nuclear physics
• the nature of electromagnetic radiation
• production of X-rays
Knowledge of the
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 4
1.2. CLASSIFICATION OF RADIATION
Radiation may be classified as:
Electromagnetic radiation Particulate radiation
• radiofrequency
• infrared
• visible light
• ultraviolet
• X rays
• gamma rays
• electrons
• positrons
• protons
• neutrons
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 5
1.2. CLASSIFICATION OF RADIATION
1.2.1. Electromagnetic radiation
c
x
y
z
Eo
Bo
λ
c
x
y
z
Eo
Bo
λ
Electromagnetic waves
consist of oscillating electric
and magnetic fields, which are
at right angles to each other
and also to the direction of
wave propagation
They are characterized by their:
• amplitudes Eo and Bo
• wavelength ( λ )
• frequency (ν ) and
• speed c = λ ν
In vacuum, c = 3×108m/s
For X rays:
• wavelength is usually
expressed in nanometre (nm)
(1 nm = 10-9m) and
• frequency is expressed in hertz (Hz)
(1 Hz = 1 cycle/sec = 1 sec-1)
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 6
1.2. CLASSIFICATION OF RADIATION
1.2.1. Electromagnetic radiation
Electromagnetic spectrum as a function of:
• wavelength (nm)
• frequency (Hz)
WAVELENGTH (nm)
FREQUENCY (Hz)
1015 1012 109 106 10-6
103 1 10-3
3x102 3x105 3x108 3x1011 3x1014 3x1017 3x1020 3x1023
Radio
Television
Radar
MRI
Infrared
Ultra
violet Gamma rays
X Rays
diagnostic therapeutic
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 7
1.2. CLASSIFICATION OF RADIATION
1.2.1. Electromagnetic radiation
Electromagnetic spectrum as a function of:
• photon energy (eV)
ENERGY (eV)
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 8
1.2 CLASSIFICATION OF RADIATION
1.2.1. Electromagnetic radiation
When interactions with matter are considered,
electromagnetic radiation is generally treated as series of
individual particles, known as photons. The energy E of
each photon is given by:
λ
/
hc
hv
E =
=
h (Planck’s constant) = 6.63×10-34 J·s = 4.14×10-15 eV·s
1 eV = 1.6×10-19 J, is the energy given to an electron by accelerating it through
1 volt of electric potential difference
ν (Hz = s-1) is the frequency of electromagnetic wave
λ (m) is the wavelength of electromagnetic wave
In diagnostic radiology the photon energy is usually expressed in units
of keV. 1 keV = 1000 eV
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 9
1.2. CLASSIFICATION OF RADIATION
1.2.2. Particulate radiation
In diagnostic radiology, the only
particulate radiation that needs to be
considered is the electron
rest mass of electron = 9.109 ×10-31 kg
rest energy of electron = 511 keV = 0.511 MeV
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 10
1.2. CLASSIFICATION OF RADIATION
1.2.3. Ionizing and non-ionizing radiation
Non-ionizing radiation - cannot ionize
matter: (electromagnetic radiation with
energy below the far-ultraviolet region, e.g.
visible light, infrared and radiofrequency)
Ionizing radiation - can ionize matter: (fast
charged particles, X rays, gamma rays and
neutrons)
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 11
Ionizing radiation - can ionize matter either:
Directly:
fast charged particles that
deposit their energy in matter
directly, through many small
Coulomb (electrostatic)
interactions with orbital
electrons along the particle
track
Indirectly:
X- or gamma- ray photons or
neutrons that first transfer their
energy to fast charged particles
released in one or a few
interactions in the matter through
which they pass. The resulting fast
charged particles then deposit
their energy directly in the matter
1.2. CLASSIFICATION OF RADIATION
1.2.3. Ionizing and non-ionizing radiation
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 12
Ionization potential is the minimum energy
required to ionize an atom. For elements its
magnitude ranges from a few eV for alkali
metals to 24.5 eV for helium. For water it is
12.6 eV
1.2. CLASSIFICATION OF RADIATION
1.2.3. Ionizing and non-ionizing radiation
Element Ionization potential (eV)
H 13.6
C 11.3
O 13.6
Mo 7.1
W 7.9
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 13
1.3. ATOMIC AND NUCLEAR STRUCTURE
1.3.1. Basic definitions
Most of the mass of the atom is concentrated in the
atomic nucleus which consists of:
• Z protons and
• (A – Z) = N neutrons
Z: Atomic number
A: Atomic mass number
Unified atomic mass unit µ: a unit used for specifying
the masses of atoms
1 µ = 1/12 of the mass of the 12C atom or 931.5 MeV/c2
An atom is composed of a central nucleus surrounded
by a cloud of negatively charged electrons
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 14
1.3. ATOMIC AND NUCLEAR STRUCTURE
1.3.1. Basic definitions
Particle Charge (C) Rest energy (MeV)
Electron (e) - 1.602×10-19 0.511
Proton (p) +1.602×10-19 938.28
Neutron (n) 0 939.57
Radius of an atom ≈ 0.1 nm
Radius of the nucleus ≈ 10-5 nm
In a non-ionised atom:
number of electrons = number of protons
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 15
1.3. ATOMIC AND NUCLEAR STRUCTURE
1.3.1. Basic definitions
Protons and neutrons are referred to as nucleons
They are bound in the nucleus with the strong force
The strong force between two nucleons is a very
short-range force, active only at distances of the
order of a few femtometer (fm). 1 fm = 10-15 m
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 16
1.3. ATOMIC AND NUCLEAR STRUCTURE
1.3.1. Basic definitions
Cs
137
55
3
/
2
A
0155
.
0
98
.
1
A
+
=
Z
Empirical relation between A and Z
Ra
226
88
Co
60
27
nucleus of Cobalt-60
with 27 protons and
33 neutrons
nucleus of Cesium-137
with 55 protons and
82 neutrons
nucleus of Radium-226
with 88 protons and
138 neutrons
X
A
Z
Chemical
symbol for
the element
Atomic mass
number =
Z+N
Atomic
number
X-A
or
(Co-60)
(Cs-137)
(Ra-226)
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 17
1.3. ATOMIC AND NUCLEAR STRUCTURE
1.3.1. Basic definitions
Isotopes of a given element have in the
nucleus :
• same number of protons, but
• different numbers of neutrons
Isotopes of chemical element hydrogen (Z = 1)
Isotopes of chemical element carbon (Z = 6)
ordinary hydrogen
deuterium
tritium
C
C
C
14
6
13
6
12
6
H
H
H
3
1
2
1
1
1
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 18
1.3. ATOMIC AND NUCLEAR STRUCTURE
1.3.1. Basic definitions
Atomic weight Ar is a dimensionless physical quantity
The average is a weighted mean over all the isotopes of
the particular element taking account of their relative
abundance
Atomic mass M is expressed in unified atomic mass unit
The atomic mass M for a particular isotope is smaller
than the sum of the individual masses of constituent
particles because of the intrinsic energy associated with
binding the particles (nucleons) within the nucleus
unit
mass
atomic
unified
element
an
of
atoms
the
of
mass
average
=
r
A
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 19
1.3. ATOMIC AND NUCLEAR STRUCTURE
1.3.1. Basic definitions
Atomic g-atom (gram-atom) is the number of grams
of an atomic substance that contains a number of
atoms exactly equal to one Avogadro’s constant
(NA = 6.022 × 1023 atoms/g-atom)
Atomic weight definition means that Ar grams of
each element contain exactly NA atoms. For a single
isotope M grams contain NA atoms
Example:
• 1 gram-atom of Cobalt- 60 is 59.93 g of Co-60
• 1 gram-atom of Radium-226 is 226.03 g of Ra-226
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 20
Molecular g-mole (gram-mole) is defined as the number
of grams of a molecular compound that contains exactly
one Avogadro’s constant of molecules
(NA = 6.022 × 1023 molecule/g-mole)
The mass of a molecule is the sum of the masses of the
atoms that make up the molecule
Example:
• 1 gram-mole of water is ≈18 g of water
• 1 gram-mole of carbon dioxide is ≈ 44 g of carbon dioxide
1.3. ATOMIC AND NUCLEAR STRUCTURE
1.3.1. Basic definitions
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 21
Note that (Z/ Ar) ≈ 0.5 for all elements, except for hydrogen, for
which (Z/ Ar) = 1. Actually, (Z/Ar) slowly decreases from 0.5 for
low Z elements to 0.4 for high Z elements
NA: Avogadro constant, Z : atomic number
Ar : atomic weight, ρ : density
1.3. ATOMIC AND NUCLEAR STRUCTURE
1.3.1. Basic definitions
Number of atoms per
unit mass of an element:
r
A
am
A
N
N =
Number of electrons per unit
volume of an element:
r
A
am
aV
A
N
Z
ZN
ZN ρ
ρ =
=
Number of electrons
per unit mass of an element: A
r
am N
A
Z
ZN =
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 22
1.3. ATOMIC AND NUCLEAR STRUCTURE
1.3.2. Atomic structure
Modern quantum mechanical model of the atom is
built on the work of many physicists
The idea of a dense central nucleus surrounded by
orbiting electrons was first proposed by
Ernest Rutherford in 1911
Rutherford’s atomic model is based on results of
the Geiger- Marsden experiment of 1909 with
α particles emitted from Radium C, scattered on
thin gold foils with a thickness of 0.00004 cm
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 23
Geiger and Marsden found that:
• more than 99% of the α particles incident on the gold foil were
scattered at scattering angles less than 3o
• roughly 1 in 104 alpha particles was scattered with a scattering
angle exceeding 90o
This finding (1 in 104) was in drastic disagreement with the
theoretical prediction of one in 103500 resulting from Thomson’s
atomic model
positive charge
negative electrons
Thomson atomic model Rutherford atomic model
positive charge
negative electrons
1.3. ATOMIC AND NUCLEAR STRUCTURE
1.3.2. Atomic structure
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 24
Rutherford proposed that:
• mass and positive charge of the
atom are concentrated in the
nucleus of the size of the order
of 10-15 m
• negatively charged electrons
revolve about the nucleus with a
radius of the order of 10-10 m
positive charge
negative electrons
Rutherford atomic model
1.3. ATOMIC AND NUCLEAR STRUCTURE
1.3.2. Atomic structure
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 25
The Rutherford atomic model, however, had a
number of unsatisfactory features
For example, it could not explain the observed
emission spectra of the elements
Visible lines of emission spectrum for Hydrogen
1.3. ATOMIC AND NUCLEAR STRUCTURE
1.3.2. Atomic structure
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 26
In 1913, Niels Bohr elaborated the model of hydrogen
atom, based on four postulates:
• the electron revolves in circular allowed orbit about the proton under the
influence of the Coulomb force of attraction being balanced by the
centripetal force arising from the orbital motion
• while in orbit, the electron does not lose any energy in spite of being
constantly accelerated
• the angular momentum of the electron in an allowed orbit is quantized and
only takes values of nћ, where n is an integer and ћ = h/2π, where h is
Planck’s constant
• an atom emits radiation when an electron
makes a transition from an initial orbit with
quantum number ni to a final orbit with
quantum number nf for ni > nf.
ni
nf
Ei
Ef
E = Ei - Ef
1.3. ATOMIC AND NUCLEAR STRUCTURE
1.3.2. Atomic structure
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 27
Diagram representing
Bohr’s model of the
hydrogen atom, in which
the orbiting electron is
allowed to be only in
specific orbits of
discrete radii
proton
M, + e
r
electron
m, - e
F
v
ground state
excited state
Quantization of energy, with n = 1, 2, 3...
2
6
.
13
)
eV
(
n
En −
=
1.3. ATOMIC AND NUCLEAR STRUCTURE
1.3.2. Atomic structure
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 28
Whilst the work of Bohr was a major
breakthrough, successfully explaining
aspects of the behaviour of the
hydrogen atom, the singly ionized
helium atom, and the doubly ionized
lithium atom, etc., the story did not stop
there
1.3. ATOMIC AND NUCLEAR STRUCTURE
1.3.2. Atomic structure
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 29
Through the work of Heisenberg, Schrödinger, Dirac,
Pauli and others the theory of quantum mechanics was
developed. In this theory, the electrons occupy
individual energy states defined by four quantum
numbers as follows:
• the principal quantum number, n, which can take integer values
and specifies the main energy shell
• the azimuthal quantum number, l, which can take integer
values between 0 and n − 1
• the magnetic quantum number, m, which can take integer
values between – l and +l
• the spin quantum number, s, which takes values -1/2 or +1/2 and
specifies a component of the spin angular momentum of the
electron
1.3. ATOMIC AND NUCLEAR STRUCTURE
1.3.2. Atomic structure
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 30
According to the Pauli Exclusion
Principle, no two electrons can
occupy the same state and it follows
that the number of electron states
that can share the same principal
quantum number n is equal to 2n2
The energy levels associated with n = 1, 2, 3 etc.
are known as the K, L, M etc. bands
1.3. ATOMIC AND NUCLEAR STRUCTURE
1.3.2. Atomic structure
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 31
Zero Valence e-
N
M
K
-13.6
-3.4
-1.51
Hydrogen Z = 1
K series
L series
Energy (eV)
L
Energy (eV)
N
M
L
K
L series
K series
Tungsten Z = 74
Valence e-
Zero
- 11,500
- 69,500
- 2,300
Energy levels for hydrogen and tungsten. Possible
transitions between the various energy levels are
shown with arrows
1.3. ATOMIC AND NUCLEAR STRUCTURE
1.3.2. Atomic structure
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 32
1.4. X RAYS
1.4.1. The production of characteristic X rays and Auger electrons
When charged particles pass through matter they
interact with the atomic electrons and lose energy
through the processes of ionization and excitation
ionization
Atom of Na
K
L
M
ground state
K
L
M
K
L
M
ionization
K
L
M
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 33
If the transferred energy
exceeds the binding energy of
the electron, ionization occurs,
resulting in the electron
ejected from the atom. An
ion pair consisting of the
ejected electron and the
ionized, positively charged
atom is then formed
The average energy required
to produce an ion pair in air or
soft tissue for electrons is
equal to 33.97 eV
K
L
M
K
L
M
ejected electron
positive ion
ion pair
ion pair
1.4. X RAYS
1.4.1. The production of characteristic X rays and Auger electrons
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 34
When charged particles pass through matter they
interact with the atomic electrons and lose energy
through the processes of ionization and excitation
1.4. X RAYS
1.4.1. The production of characteristic X rays and Auger electrons
K
L
M
Atom of Na
ground state
excited state
excitation
K
L
M
de-excitation
E = hν = Ei - Ef
K
L
M
E = hν
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 35
Whenever a vacancy is created in an inner
electronic shell, it is filled by an electron
from a more distant (outer) shell
This results in a vacancy in this second
outer shell which is then filled by an
electron (if available) from an even more
distant outer shell and the whole process
repeats producing a cascade of transitions
1.4. X RAYS
1.4.1. The production of characteristic X rays and Auger electrons
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 36
The energy released in each transition is carried
away by:
• the emission of electromagnetic radiation
depending on the atomic number of the
material, and the electronic shells
involved, this radiation may be in the
visible, ultraviolet, and X ray portions
of the spectrum
in case of X rays, they are known as
characteristic or fluorescent X rays
1.4. X RAYS
1.4.1. The production of characteristic X rays and Auger electrons
• an electron ejected from another outer shell,
known as Auger electron
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 37
1.4. X RAYS
1.4.1. The production of characteristic X rays
K
M
L
Kα
K
M
L
Kα
K
M
L
Kα
K
M
L Kβ
K
M
L Kβ
K
M
L Kβ
K
M
L
K
M
L
K
M
L
Kα
K
M
L
Kα
K
M
L
Kα
K
M
L Kβ
K
M
L Kβ
K
M
L Kβ
K
M
L
Kα
K
M
L
Kα
K
M
L
Kα
K
M
L
Kα
K
M
L
Kα
K
M
L
Kα
K
M
L Kβ
K
M
L Kβ
K
M
L Kβ
K
M
L
K
M
L
• Kα X ray is emitted for a
transition between
L and K shells
• Kβ X ray is emitted for a
transition between
M or N and K shells
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 38
For tungsten (W):
the energies of the Kα and Kβ characteristic X rays
are given by:
E (Kα1) = ELIII - EK = - 10.2 - (- 69.5) = 59.3 keV
E (Kα2) = ELI - EK = - 11.5- (- 69.5) = 58.0 keV
E (Kβ1) = EMIII - EK = - 2.3 - (- 69.5) = 67.2 keV
E (Kβ2) = ENIII- EK = - 0.4 - (- 69.5) = 69.1 keV
1.4. X RAYS
1.4.1. The production of characteristic X rays
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 39
For molybdenum (Mo):
Energies of K, L and M shell
are:
EK = - 20.0 keV
EL = - 2.6 keV
EM = - 0.4 keV
the energies of the Kα and Kβ
characteristic X rays are
given by:
E (Kα) = EL - EK = - 2.6 - (- 20.0) = 17.4 keV
E (Kβ) = EM - EK = - 0.4 - (- 20.0) = 19.6 keV
1.4. X RAYS
1.4.1. The production of characteristic X rays
cascading
electron
K L M
-20 keV
-2.6 keV
-0.4 keV -
-
- -
-
19.6 keV Kβ
Characteristic
X ray
vacant
-
Molybdenum
atom
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 40
1.4. X RAYS
1.4.1. The production of Auger electrons
If the initial transition is from an M
to a K shell, and the Auger
electron is also emitted from the
M shell, there will be two resultant
vacancies in the M shell
The kinetic energy of the Auger
electron is thus determined by the
difference between the binding
energy of the shell with the initial
vacancy and the sum of the
binding energies associated with
the two vacancies which are
created. In case of molybdenum
atom, the energy of the Auger
electron is given by:
E (Auger) = EM + EM - EK = - 0.4 - 0.4 - (- 20.0) = 19.2 keV
cascading
electron
K L M
-20 keV
-2.6 keV
-0.4 keV -
-
- - -
-
19.2 keV
Auger
electron
vacant
Molybdenum
atom
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 41
Auger electron emission is more important for materials of
low atomic number and for transitions amongst outer shells
The K-fluorescence yield is close to zero for low atomic
number materials, but increases with atomic number and is
0.007, 0.17, 0.60 and 0.93 for oxygen, calcium, selenium and
gadolinium respectively
When considering energy deposition in matter it is important
to know whether a fluorescent X ray or an Auger electron is
emitted
The probability of emission of a fluorescent X ray is known as
the fluorescent yield, denoted ω and the probability of
emitting an Auger electron is 1- ω
1.4. X RAYS
1.4.1. The production of characteristic X rays and Auger electrons
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 42
1.4. X RAYS
1.4.2. Radiation from an accelerated charge, Bremsstrahlung
In inelastic interactions of the fast electrons with atomic
nuclei as they pass through matter, the electron path is
deflected and energy is transferred to a photon, which is
emitted
The emitted photon is known
as Bremsstrahlung, which
means “brake radiation”, in
German
The energy of the emitted
photon can take any value from
zero up to the energy of the
initial electron, producing a
continuous spectrum
Bremsstrahlung photons are the
major component of the X ray
spectrum emitted by X ray tubes
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 43
The angle of emission of the Bremsstrahlung photons
depends upon the electron energy:
• for electron energies much greater than the rest
energy of the electron, the angular distribution is
peaked in the forward direction
• when the electron energy is low, the radiation is mainly
emitted between 60 and 90 degrees to the forward
direction
The probability of Bremsstrahlung emission is
proportional to Z2. But even for tungsten (Z = 74) the
efficiency of Bremsstrahlung production is less than 1%
for 100 keV electrons
1.4. X RAYS
1.4.2. Radiation from an accelerated charge, Bremsstrahlung
IAEA
Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 44
BIBLIOGRAPHY
• ATTIX, F.H., Introduction to Radiological Physics and
Radiation Dosimetry, John Wiley & Sons, New York
(1986)
• BUSHBERG, J.T., SEIBERT, J.A., LEIDHOLDT, E.M.J.,
BOONE, J.M., The Essential Physics of Medical Imaging,
2nd edn, Williams and Wilkins (2002)
• INTERNATIONAL ATOMIC ENERGY AGENCY, Radiation
Oncology Physics: A Handbook for Teachers and
Students, IAEA, Vienna (2005). http://www.
naweb.iaea.org/nahu/dmrp/publication.asp
• JOHNS, H.E., CUNNINGHAM, J.R., The Physics of
Radiology, 4th edn, Thomas, Springfield (1983)

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funndamental of atomic nuclear physics: chapter 1

  • 1. IAEA International Atomic Energy Agency Slide set of 44 slides based on the chapter authored by K. H. Ng and D. R. Dance of the IAEA publication (ISBN 978-92-0-131010-1): Diagnostic Radiology Physics: A Handbook for Teachers and Students Objective: To familiarize students with basic principles of atomic and nuclear Physics used in diagnostic radiology Chapter 1: Fundamentals of Atomic and Nuclear Physics Slide set prepared by E.Okuno (S. Paulo, Brazil, Institute of Physics of S. Paulo University)
  • 2. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 2 Chapter 1. TABLE OF CONTENTS 1.1. Introduction 1.2. Classification of radiation 1.3. Atomic and nuclear structure 1.4. X rays
  • 3. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 3 1.1 INTRODUCTION is fundamental to the understanding of the physics of medical imaging and radiation protection. This, the first chapter of the Handbook, summarises those aspects of these areas which, being part of the foundation of modern physics, underpin the remainder of the book • structure of the atom • elementary nuclear physics • the nature of electromagnetic radiation • production of X-rays Knowledge of the
  • 4. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 4 1.2. CLASSIFICATION OF RADIATION Radiation may be classified as: Electromagnetic radiation Particulate radiation • radiofrequency • infrared • visible light • ultraviolet • X rays • gamma rays • electrons • positrons • protons • neutrons
  • 5. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 5 1.2. CLASSIFICATION OF RADIATION 1.2.1. Electromagnetic radiation c x y z Eo Bo λ c x y z Eo Bo λ Electromagnetic waves consist of oscillating electric and magnetic fields, which are at right angles to each other and also to the direction of wave propagation They are characterized by their: • amplitudes Eo and Bo • wavelength ( λ ) • frequency (ν ) and • speed c = λ ν In vacuum, c = 3×108m/s For X rays: • wavelength is usually expressed in nanometre (nm) (1 nm = 10-9m) and • frequency is expressed in hertz (Hz) (1 Hz = 1 cycle/sec = 1 sec-1)
  • 6. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 6 1.2. CLASSIFICATION OF RADIATION 1.2.1. Electromagnetic radiation Electromagnetic spectrum as a function of: • wavelength (nm) • frequency (Hz) WAVELENGTH (nm) FREQUENCY (Hz) 1015 1012 109 106 10-6 103 1 10-3 3x102 3x105 3x108 3x1011 3x1014 3x1017 3x1020 3x1023 Radio Television Radar MRI Infrared Ultra violet Gamma rays X Rays diagnostic therapeutic
  • 7. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 7 1.2. CLASSIFICATION OF RADIATION 1.2.1. Electromagnetic radiation Electromagnetic spectrum as a function of: • photon energy (eV) ENERGY (eV)
  • 8. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 8 1.2 CLASSIFICATION OF RADIATION 1.2.1. Electromagnetic radiation When interactions with matter are considered, electromagnetic radiation is generally treated as series of individual particles, known as photons. The energy E of each photon is given by: λ / hc hv E = = h (Planck’s constant) = 6.63×10-34 J·s = 4.14×10-15 eV·s 1 eV = 1.6×10-19 J, is the energy given to an electron by accelerating it through 1 volt of electric potential difference ν (Hz = s-1) is the frequency of electromagnetic wave λ (m) is the wavelength of electromagnetic wave In diagnostic radiology the photon energy is usually expressed in units of keV. 1 keV = 1000 eV
  • 9. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 9 1.2. CLASSIFICATION OF RADIATION 1.2.2. Particulate radiation In diagnostic radiology, the only particulate radiation that needs to be considered is the electron rest mass of electron = 9.109 ×10-31 kg rest energy of electron = 511 keV = 0.511 MeV
  • 10. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 10 1.2. CLASSIFICATION OF RADIATION 1.2.3. Ionizing and non-ionizing radiation Non-ionizing radiation - cannot ionize matter: (electromagnetic radiation with energy below the far-ultraviolet region, e.g. visible light, infrared and radiofrequency) Ionizing radiation - can ionize matter: (fast charged particles, X rays, gamma rays and neutrons)
  • 11. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 11 Ionizing radiation - can ionize matter either: Directly: fast charged particles that deposit their energy in matter directly, through many small Coulomb (electrostatic) interactions with orbital electrons along the particle track Indirectly: X- or gamma- ray photons or neutrons that first transfer their energy to fast charged particles released in one or a few interactions in the matter through which they pass. The resulting fast charged particles then deposit their energy directly in the matter 1.2. CLASSIFICATION OF RADIATION 1.2.3. Ionizing and non-ionizing radiation
  • 12. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 12 Ionization potential is the minimum energy required to ionize an atom. For elements its magnitude ranges from a few eV for alkali metals to 24.5 eV for helium. For water it is 12.6 eV 1.2. CLASSIFICATION OF RADIATION 1.2.3. Ionizing and non-ionizing radiation Element Ionization potential (eV) H 13.6 C 11.3 O 13.6 Mo 7.1 W 7.9
  • 13. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 13 1.3. ATOMIC AND NUCLEAR STRUCTURE 1.3.1. Basic definitions Most of the mass of the atom is concentrated in the atomic nucleus which consists of: • Z protons and • (A – Z) = N neutrons Z: Atomic number A: Atomic mass number Unified atomic mass unit µ: a unit used for specifying the masses of atoms 1 µ = 1/12 of the mass of the 12C atom or 931.5 MeV/c2 An atom is composed of a central nucleus surrounded by a cloud of negatively charged electrons
  • 14. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 14 1.3. ATOMIC AND NUCLEAR STRUCTURE 1.3.1. Basic definitions Particle Charge (C) Rest energy (MeV) Electron (e) - 1.602×10-19 0.511 Proton (p) +1.602×10-19 938.28 Neutron (n) 0 939.57 Radius of an atom ≈ 0.1 nm Radius of the nucleus ≈ 10-5 nm In a non-ionised atom: number of electrons = number of protons
  • 15. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 15 1.3. ATOMIC AND NUCLEAR STRUCTURE 1.3.1. Basic definitions Protons and neutrons are referred to as nucleons They are bound in the nucleus with the strong force The strong force between two nucleons is a very short-range force, active only at distances of the order of a few femtometer (fm). 1 fm = 10-15 m
  • 16. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 16 1.3. ATOMIC AND NUCLEAR STRUCTURE 1.3.1. Basic definitions Cs 137 55 3 / 2 A 0155 . 0 98 . 1 A + = Z Empirical relation between A and Z Ra 226 88 Co 60 27 nucleus of Cobalt-60 with 27 protons and 33 neutrons nucleus of Cesium-137 with 55 protons and 82 neutrons nucleus of Radium-226 with 88 protons and 138 neutrons X A Z Chemical symbol for the element Atomic mass number = Z+N Atomic number X-A or (Co-60) (Cs-137) (Ra-226)
  • 17. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 17 1.3. ATOMIC AND NUCLEAR STRUCTURE 1.3.1. Basic definitions Isotopes of a given element have in the nucleus : • same number of protons, but • different numbers of neutrons Isotopes of chemical element hydrogen (Z = 1) Isotopes of chemical element carbon (Z = 6) ordinary hydrogen deuterium tritium C C C 14 6 13 6 12 6 H H H 3 1 2 1 1 1
  • 18. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 18 1.3. ATOMIC AND NUCLEAR STRUCTURE 1.3.1. Basic definitions Atomic weight Ar is a dimensionless physical quantity The average is a weighted mean over all the isotopes of the particular element taking account of their relative abundance Atomic mass M is expressed in unified atomic mass unit The atomic mass M for a particular isotope is smaller than the sum of the individual masses of constituent particles because of the intrinsic energy associated with binding the particles (nucleons) within the nucleus unit mass atomic unified element an of atoms the of mass average = r A
  • 19. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 19 1.3. ATOMIC AND NUCLEAR STRUCTURE 1.3.1. Basic definitions Atomic g-atom (gram-atom) is the number of grams of an atomic substance that contains a number of atoms exactly equal to one Avogadro’s constant (NA = 6.022 × 1023 atoms/g-atom) Atomic weight definition means that Ar grams of each element contain exactly NA atoms. For a single isotope M grams contain NA atoms Example: • 1 gram-atom of Cobalt- 60 is 59.93 g of Co-60 • 1 gram-atom of Radium-226 is 226.03 g of Ra-226
  • 20. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 20 Molecular g-mole (gram-mole) is defined as the number of grams of a molecular compound that contains exactly one Avogadro’s constant of molecules (NA = 6.022 × 1023 molecule/g-mole) The mass of a molecule is the sum of the masses of the atoms that make up the molecule Example: • 1 gram-mole of water is ≈18 g of water • 1 gram-mole of carbon dioxide is ≈ 44 g of carbon dioxide 1.3. ATOMIC AND NUCLEAR STRUCTURE 1.3.1. Basic definitions
  • 21. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 21 Note that (Z/ Ar) ≈ 0.5 for all elements, except for hydrogen, for which (Z/ Ar) = 1. Actually, (Z/Ar) slowly decreases from 0.5 for low Z elements to 0.4 for high Z elements NA: Avogadro constant, Z : atomic number Ar : atomic weight, ρ : density 1.3. ATOMIC AND NUCLEAR STRUCTURE 1.3.1. Basic definitions Number of atoms per unit mass of an element: r A am A N N = Number of electrons per unit volume of an element: r A am aV A N Z ZN ZN ρ ρ = = Number of electrons per unit mass of an element: A r am N A Z ZN =
  • 22. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 22 1.3. ATOMIC AND NUCLEAR STRUCTURE 1.3.2. Atomic structure Modern quantum mechanical model of the atom is built on the work of many physicists The idea of a dense central nucleus surrounded by orbiting electrons was first proposed by Ernest Rutherford in 1911 Rutherford’s atomic model is based on results of the Geiger- Marsden experiment of 1909 with α particles emitted from Radium C, scattered on thin gold foils with a thickness of 0.00004 cm
  • 23. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 23 Geiger and Marsden found that: • more than 99% of the α particles incident on the gold foil were scattered at scattering angles less than 3o • roughly 1 in 104 alpha particles was scattered with a scattering angle exceeding 90o This finding (1 in 104) was in drastic disagreement with the theoretical prediction of one in 103500 resulting from Thomson’s atomic model positive charge negative electrons Thomson atomic model Rutherford atomic model positive charge negative electrons 1.3. ATOMIC AND NUCLEAR STRUCTURE 1.3.2. Atomic structure
  • 24. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 24 Rutherford proposed that: • mass and positive charge of the atom are concentrated in the nucleus of the size of the order of 10-15 m • negatively charged electrons revolve about the nucleus with a radius of the order of 10-10 m positive charge negative electrons Rutherford atomic model 1.3. ATOMIC AND NUCLEAR STRUCTURE 1.3.2. Atomic structure
  • 25. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 25 The Rutherford atomic model, however, had a number of unsatisfactory features For example, it could not explain the observed emission spectra of the elements Visible lines of emission spectrum for Hydrogen 1.3. ATOMIC AND NUCLEAR STRUCTURE 1.3.2. Atomic structure
  • 26. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 26 In 1913, Niels Bohr elaborated the model of hydrogen atom, based on four postulates: • the electron revolves in circular allowed orbit about the proton under the influence of the Coulomb force of attraction being balanced by the centripetal force arising from the orbital motion • while in orbit, the electron does not lose any energy in spite of being constantly accelerated • the angular momentum of the electron in an allowed orbit is quantized and only takes values of nћ, where n is an integer and ћ = h/2π, where h is Planck’s constant • an atom emits radiation when an electron makes a transition from an initial orbit with quantum number ni to a final orbit with quantum number nf for ni > nf. ni nf Ei Ef E = Ei - Ef 1.3. ATOMIC AND NUCLEAR STRUCTURE 1.3.2. Atomic structure
  • 27. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 27 Diagram representing Bohr’s model of the hydrogen atom, in which the orbiting electron is allowed to be only in specific orbits of discrete radii proton M, + e r electron m, - e F v ground state excited state Quantization of energy, with n = 1, 2, 3... 2 6 . 13 ) eV ( n En − = 1.3. ATOMIC AND NUCLEAR STRUCTURE 1.3.2. Atomic structure
  • 28. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 28 Whilst the work of Bohr was a major breakthrough, successfully explaining aspects of the behaviour of the hydrogen atom, the singly ionized helium atom, and the doubly ionized lithium atom, etc., the story did not stop there 1.3. ATOMIC AND NUCLEAR STRUCTURE 1.3.2. Atomic structure
  • 29. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 29 Through the work of Heisenberg, Schrödinger, Dirac, Pauli and others the theory of quantum mechanics was developed. In this theory, the electrons occupy individual energy states defined by four quantum numbers as follows: • the principal quantum number, n, which can take integer values and specifies the main energy shell • the azimuthal quantum number, l, which can take integer values between 0 and n − 1 • the magnetic quantum number, m, which can take integer values between – l and +l • the spin quantum number, s, which takes values -1/2 or +1/2 and specifies a component of the spin angular momentum of the electron 1.3. ATOMIC AND NUCLEAR STRUCTURE 1.3.2. Atomic structure
  • 30. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 30 According to the Pauli Exclusion Principle, no two electrons can occupy the same state and it follows that the number of electron states that can share the same principal quantum number n is equal to 2n2 The energy levels associated with n = 1, 2, 3 etc. are known as the K, L, M etc. bands 1.3. ATOMIC AND NUCLEAR STRUCTURE 1.3.2. Atomic structure
  • 31. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 31 Zero Valence e- N M K -13.6 -3.4 -1.51 Hydrogen Z = 1 K series L series Energy (eV) L Energy (eV) N M L K L series K series Tungsten Z = 74 Valence e- Zero - 11,500 - 69,500 - 2,300 Energy levels for hydrogen and tungsten. Possible transitions between the various energy levels are shown with arrows 1.3. ATOMIC AND NUCLEAR STRUCTURE 1.3.2. Atomic structure
  • 32. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 32 1.4. X RAYS 1.4.1. The production of characteristic X rays and Auger electrons When charged particles pass through matter they interact with the atomic electrons and lose energy through the processes of ionization and excitation ionization Atom of Na K L M ground state K L M K L M ionization K L M
  • 33. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 33 If the transferred energy exceeds the binding energy of the electron, ionization occurs, resulting in the electron ejected from the atom. An ion pair consisting of the ejected electron and the ionized, positively charged atom is then formed The average energy required to produce an ion pair in air or soft tissue for electrons is equal to 33.97 eV K L M K L M ejected electron positive ion ion pair ion pair 1.4. X RAYS 1.4.1. The production of characteristic X rays and Auger electrons
  • 34. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 34 When charged particles pass through matter they interact with the atomic electrons and lose energy through the processes of ionization and excitation 1.4. X RAYS 1.4.1. The production of characteristic X rays and Auger electrons K L M Atom of Na ground state excited state excitation K L M de-excitation E = hν = Ei - Ef K L M E = hν
  • 35. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 35 Whenever a vacancy is created in an inner electronic shell, it is filled by an electron from a more distant (outer) shell This results in a vacancy in this second outer shell which is then filled by an electron (if available) from an even more distant outer shell and the whole process repeats producing a cascade of transitions 1.4. X RAYS 1.4.1. The production of characteristic X rays and Auger electrons
  • 36. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 36 The energy released in each transition is carried away by: • the emission of electromagnetic radiation depending on the atomic number of the material, and the electronic shells involved, this radiation may be in the visible, ultraviolet, and X ray portions of the spectrum in case of X rays, they are known as characteristic or fluorescent X rays 1.4. X RAYS 1.4.1. The production of characteristic X rays and Auger electrons • an electron ejected from another outer shell, known as Auger electron
  • 37. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 37 1.4. X RAYS 1.4.1. The production of characteristic X rays K M L Kα K M L Kα K M L Kα K M L Kβ K M L Kβ K M L Kβ K M L K M L K M L Kα K M L Kα K M L Kα K M L Kβ K M L Kβ K M L Kβ K M L Kα K M L Kα K M L Kα K M L Kα K M L Kα K M L Kα K M L Kβ K M L Kβ K M L Kβ K M L K M L • Kα X ray is emitted for a transition between L and K shells • Kβ X ray is emitted for a transition between M or N and K shells
  • 38. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 38 For tungsten (W): the energies of the Kα and Kβ characteristic X rays are given by: E (Kα1) = ELIII - EK = - 10.2 - (- 69.5) = 59.3 keV E (Kα2) = ELI - EK = - 11.5- (- 69.5) = 58.0 keV E (Kβ1) = EMIII - EK = - 2.3 - (- 69.5) = 67.2 keV E (Kβ2) = ENIII- EK = - 0.4 - (- 69.5) = 69.1 keV 1.4. X RAYS 1.4.1. The production of characteristic X rays
  • 39. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 39 For molybdenum (Mo): Energies of K, L and M shell are: EK = - 20.0 keV EL = - 2.6 keV EM = - 0.4 keV the energies of the Kα and Kβ characteristic X rays are given by: E (Kα) = EL - EK = - 2.6 - (- 20.0) = 17.4 keV E (Kβ) = EM - EK = - 0.4 - (- 20.0) = 19.6 keV 1.4. X RAYS 1.4.1. The production of characteristic X rays cascading electron K L M -20 keV -2.6 keV -0.4 keV - - - - - 19.6 keV Kβ Characteristic X ray vacant - Molybdenum atom
  • 40. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 40 1.4. X RAYS 1.4.1. The production of Auger electrons If the initial transition is from an M to a K shell, and the Auger electron is also emitted from the M shell, there will be two resultant vacancies in the M shell The kinetic energy of the Auger electron is thus determined by the difference between the binding energy of the shell with the initial vacancy and the sum of the binding energies associated with the two vacancies which are created. In case of molybdenum atom, the energy of the Auger electron is given by: E (Auger) = EM + EM - EK = - 0.4 - 0.4 - (- 20.0) = 19.2 keV cascading electron K L M -20 keV -2.6 keV -0.4 keV - - - - - - 19.2 keV Auger electron vacant Molybdenum atom
  • 41. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 41 Auger electron emission is more important for materials of low atomic number and for transitions amongst outer shells The K-fluorescence yield is close to zero for low atomic number materials, but increases with atomic number and is 0.007, 0.17, 0.60 and 0.93 for oxygen, calcium, selenium and gadolinium respectively When considering energy deposition in matter it is important to know whether a fluorescent X ray or an Auger electron is emitted The probability of emission of a fluorescent X ray is known as the fluorescent yield, denoted ω and the probability of emitting an Auger electron is 1- ω 1.4. X RAYS 1.4.1. The production of characteristic X rays and Auger electrons
  • 42. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 42 1.4. X RAYS 1.4.2. Radiation from an accelerated charge, Bremsstrahlung In inelastic interactions of the fast electrons with atomic nuclei as they pass through matter, the electron path is deflected and energy is transferred to a photon, which is emitted The emitted photon is known as Bremsstrahlung, which means “brake radiation”, in German The energy of the emitted photon can take any value from zero up to the energy of the initial electron, producing a continuous spectrum Bremsstrahlung photons are the major component of the X ray spectrum emitted by X ray tubes
  • 43. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 43 The angle of emission of the Bremsstrahlung photons depends upon the electron energy: • for electron energies much greater than the rest energy of the electron, the angular distribution is peaked in the forward direction • when the electron energy is low, the radiation is mainly emitted between 60 and 90 degrees to the forward direction The probability of Bremsstrahlung emission is proportional to Z2. But even for tungsten (Z = 74) the efficiency of Bremsstrahlung production is less than 1% for 100 keV electrons 1.4. X RAYS 1.4.2. Radiation from an accelerated charge, Bremsstrahlung
  • 44. IAEA Diagnostic Radiology Physics: a Handbook for Teachers and Students – chapter 1, 44 BIBLIOGRAPHY • ATTIX, F.H., Introduction to Radiological Physics and Radiation Dosimetry, John Wiley & Sons, New York (1986) • BUSHBERG, J.T., SEIBERT, J.A., LEIDHOLDT, E.M.J., BOONE, J.M., The Essential Physics of Medical Imaging, 2nd edn, Williams and Wilkins (2002) • INTERNATIONAL ATOMIC ENERGY AGENCY, Radiation Oncology Physics: A Handbook for Teachers and Students, IAEA, Vienna (2005). http://www. naweb.iaea.org/nahu/dmrp/publication.asp • JOHNS, H.E., CUNNINGHAM, J.R., The Physics of Radiology, 4th edn, Thomas, Springfield (1983)