This document discusses the use of geographic information systems (GIS) in environmental epidemiology. It begins by describing how Dr. John Snow used maps in 1854 to identify the source of a cholera outbreak in London, which was a seminal early use of spatial analysis. The document then defines GIS and explains how it links location databases to maps to display and analyze spatial health and environmental data. Several key GIS functions are outlined, including overlays, interpolation, and buffers. The strengths of GIS for environmental epidemiology are communicating spatial patterns and relationships and enabling early warning of health issues. Some weaknesses are that maps only display information and do not prove causal relationships.