Gpat important questions with answers

GPAT PREPERATION – 2020
PART - 1
IMPORTANT QUESTIONS
EXPECTED IN GPAT 2020

Prepared by:-
Mr.Kumaran.,B.Pharm.,
Lecturer
Dept. of Pharmaceutical Analysis
G.P Pharmacy college,Jolarpet,
Tirupattur district,Tamil Nadu.
CONTACT:-
Email – rxkumaran19@gmail.com
*GPAT PASSED AT 2019*

GPAT 2020 PART – 1
Each question carries 4 marks for correct answers and -1 marks for
incorrect answers. (125 × 4 =500)
1. Human blood is a viscous fluid due to
(a) Platelets in plasma
(b) Proteins in blood
(c) RBC and WBC in blood
(d) Sodium in serum
2. Ifosfamide belongs to which group of anticancer drugs
(a) Alkylating agents
(b) Anti metabolites
(c) Mitotic inhibitors
(d) Topoisomerase inhibitors
3. Nitrosoureas used in the treatment of cancer are
(a) Carmustine
(b) 5FU
(c) Methotrexate
(d) Cisplatin
4. An antidote of cyanide poisoning is
(a) Atropine
(b) Sodium thiosulphate
(c) Dimercaprol
(d) Naloxone
5. Proof strength of 90% v/v alcohol is
(a) 57.77 % under proof
(b) 57.77 % over proof
(c) 47.77 % over proof
(d) 47.77 % under proof
6. Doxaprem is a
(a) Anti-epileptic
(b) Antidiabetic
(c) Expectorant
(d) Respiratory stimulant
7. Glucose is described
(a) A monosaccharide
(b) A disaccharide
(c) A polysaccharide
(d) An oligosaccharide

8. Lithium is absolutely contraindicated in
(a) Lactation
(b) Jaundice
(c) Diabetes
(d) Typhoid
9. Rancidity of a fat is due to
(a) Oxidation
(b) Saponification
(c) Hydrolysis
(d) Neutralisation
10. Antidote of organo phosphorous poisoning is
(a) Physostigmine
(b) Pralidoxirne
(c) Neostigmine
(d) Tubocurarine
11. Phenobarbitone is a
(a) Sedative
(b) Antipsychotic
(c) Antiphychotic
(d) Anxiolytic
12. Immunoglobin with shortest half life is
(a) Ig E
(b) Ig A
(c) Ig D
(d) Ig M
13. One among the following is a communicable disease
(a) Cancer
(b) Diabetes
(c) Hypertension
(d) Filariasis
14. The members of DTAB holds the office for years.
(a) 3
(b) 5
(c) 8
(d) 2
15. Ingestion of which of the following vitamins should be avoided by a patient taking an oral
anticoagulant:
(a) Vitamin A
(b) VitaminB
(c) Vitamin K
(d) Vitamin E

16. Which portion of heart receives oxygenated blood
(a) Left auricle
(b) Right auricle
(c) Left ventricle
(d) Right ventricle
17. The recommended illumination required for casual reading is
(a) 50 lux
(b) 100 lux
(c) 300 lux
(d) None of the above
18. Power to prohibit into India of any poison except under license
(a) State government
(b) Drug controller
(c) Parliament
(d) Central government
19. " BEAUTY VITAMIN " is
(a) Vitamin K
(b) VitaminA
(c) Vitamin C
(d) Vitamin E
20. The Central Drugs Laboratory is located at
(a) Izatnagar
(b) Kasauli
(c) Kolkata
(d) Lucknow
21. Interferon are synthesized in response to
(a) Mycoplasma
(b) Bacteria
(c) Fungi
(d) Virus
22.Year of an irresolute war between India and Pakistan that led to ‘Tashkent Pact’ between
the two countries:
(a) 1971
(b) 1965
(c) 1972
(d) 1966
23. Mechanism of action of GABA is on
(a) G-protein
(b) Tyrosine kinas
(c) PIP/DAG
(d) 5- HT

24. The steroid nucleus present in testerone is
(a) Androstane
(b) Estrane
(c) Pregestane
(d) Cholestane
25. The Medulla Oblongata is a part of human
(a) Heart
(b) Brain
(c) Liver
(d) Sex Organ
26. Western blot test is used for confirmation of
(a) Typhoid
(b) HIV
(c) Cancer
(d) Malaria
27. Deadly night shade leaf is synonym of:
(a) Senna
(b) Vasaka
(c) Belladona
(d) Datura
28. "DIGITALIS" is used as
(a) Cardiotonic
(b) Purgative
(c) Sedative
(d) Smooth muscle relaxant
29. ASPIRIN " is
(a) Acetyl salicylic acid
(b) Benzoyl salicylic acid
(c) Chloro benzoic acid
(d) Anthranilic acid
30. Which angiotensin-II receptor blocker is used in hypertension?
(a) Valsartan
(b) Amlodipine
(c) Atenolol
(d) Enalapril
32. The vitamin essential in tissue culture medium is:
(a) Pyridoxine
(b) Thiamine
(c) Nicotinic acid
(d) Inositol

33. Blood vessels taking from the lungs to the heart are
(a) Pulmonary artery
(b) Aorta
(c) Portal veins
(d) Pulmonary veins
34. Mechanism of action of Clindamycin is inhibition of
(a) Protein synthesis
(b) DNA gyrase
(c) Lysosomal enzyme
(d) Cell wall synthesis
35. What is "ALZHEIMER'S" disease
(a) It affects liver
(b) It affects Kidney
(c) It affects human immune system
(d) It is a disorder of the brain
36. Which two hormones are released from the posterior lobe of the pituitary gland
(a) ADH and GH
(b) ACTH and TSH
(c) ADH and oxytocin
(d) TRH and CRH
37. Cetrizine is a active metabolite of
(a) Hydroxyzine
(b) Promethazine
(c) Cimetidine
(d) Cinnarizine
38. Common transmission of Aids is
(a) Sexual Intercourse
(b) Blood Transfusion
(c) Placental transfusion
(d) All
39. Proton pump inhibitors
(a) Omeprazole
(b) Trimethaphan
(c) Pirenzepine
(d) Ranitidine
40. HLB system is used to classify
(a) Surfactants
(b) Preservatives
(c) Antioxidants
(d) Squestering agents

41. Absorption of a drug is effected by-
(a) Solubility
(b) Route of administration
(c) Vascularity
(d) All of the above
42. The popular drug "LOSARTAN" belongs to which class of Antihypertensive Drugs
(a) ACE Inhibitor
(b) Angiotensin-II Antagonist
(c) Calcium Channel Blocker
(d) Renin Inhibitor
43. Hemp is pericyclic fibers obtained from the stem of
(a) Linumusitatissimum
(b) Corchorousolitorius
(c) Cannabis sativa
(d)Gossypiumherbaceum
44. Which of the following is formula of Gibb’s phase rule
(a) F= C+P+1
(b) F=C-P+2
(c) F=P-C+1
(d) F= P+C+1
45. Which of the following is a synthetic sweetener
(a) Glucose
(b) Sorbitol
(c) Aspartame
(d) Sucrose
46. Pellagra is due to the deficiency of
(a) Niacin
(b) Thiamine
(c) Vitamin B12
(d) Vitamin C
47. The phase rule was first discovered by
(a) Nernst
(b) Gibbs
(c) Arrhenius
(d) Le Chatelier
48. Fibrinolytic that is antigenic
(a) Streptokinase
(b) Urokinase
(c) Altepase
(d) Cholesterol

49. Pickup element that prevents the development of dental carries
(a) Sodium
(b) Calcium
(c) Fluorine
(d) Phosphorous
50. Which of the following antibiotic is not produced by bacteria
(a) Penicillin
(b) Streptomycin
(c) Tetracycline
(d) Bacitracin
51. A license from licensing authority is not required for sale of the
(a) homeopathic medicines
(b) generic drugs
(c) cosmetics
(d) OTC drugs
52. Drug causing gynecomastia is
(a) Spironolactone
(b) Rifampicin
(c) Penicillin
(d) Bumetanide
53. Neostigmine is used in the following except
(a) Myasthenia gravis
(b) Cobra bite
(c) Atony of bladder
(d) Glaucoma
54. Digitalis toxicity is observed with
(a) K⁺ supplementation
(b) Ca²⁺ supplementation
(c) Increased parasympathetic activity
(d) Increased adrenocoticosteroid levels
55. The Schedule in drugs and Cosmetics, Act that deals with the requirements and guidelines
for clinical trails, import and manufacture of new drugs is
(a) Schedule ‘O’
(b) Schedule ‘M’
(c) Schedule ‘F’
(d) Schedule ‘Y’
56. Simethicone is component of several antiacid formulations, chemically it is
(a) Wax
(b) Fat
(c) Aldehyde
(d) Silicon

57. Alcuronium is semi synthetic derivative with properties of
(a) Gallamine
(b) Pancuronium
(c) Succinylcholine
(d) D-tubocurarine
58. Epsum salt is:
(a) Sodium sulphate
(b) Magnesium sulphate
(c) Potassium sulphate
(d) None of above
59. In a prescription “STAT” means
(a) At once
(b) Single tablet at a time
(c) Straight
(d) Stop after some time
60. Which of the following drug is for treatment of breast cancer
(a) Tamoxifen citrate
(b) Methotrexate
(c) Vinblastin
(d) Cisplatin
61. The opium that has been processed to conform to the pharmacopoeia requirements is
called …….
(a) Prepared opium
(b) Crude opium
(c) Medicinal opium
(d) Diacetylmorphine
62. Which among the following hydrocarbon have two double bonds and one ring, found in
oil
(a) Pinene
(b) Limonene
(c) Borneol
(d) Myrcene
63. Heart beat less than 60 beats/mt. is regarded as
(a) Bradycardia
(b) Tachycardia
(c) Hypotension
(d) Hypertension
64. The drug used for tuberculosis include all except
(a) Dapsone
(b) Rifampicin
(c) Ethambutol
(d) Isoniazid

65. Artesunate is
(a) Antiviral drug
(b) Antimalarial drug
(c) Antifungal drug
(d) Anticancer drug
66. Digitalis toxicity is enhanced by co-administration of which of the following?
(a) Quinidine
(b) Potassium
(c) Calcium
(d) Diuretics
67. Antisleep pills are made up off
(a) Barbiturate
(b) BZD
(c) Amphetamine
(d) Both A & B
68. First political drama of kerala
(a) Ritumati
(b) Pattabakki
(c) Aphante Makal
(d) Thozil Kendrathilekku
69. Example of both exocrine & endocrine
(a) Liver
(b) Spleen
(c) Adrenal
(d)Pancreas
70. Chewable tablet does not contain
(a) Disintegrant
(b) Binder
(c) Sweetener
(d) Lubricant
71. Goitre is caused by
(a) Excess secretion of thyroxin
(b) Deficiency of iodine
(c) Over eating
(d) Defective growth hormone
72. Dapsone is -
(a) Anti cancer drug
(b) Anti viral drug
(c) Anti fungal drug
(d) Anti leprosy drug

73. .............Is Known as father of medicine
(a) Aristotle
(b) Dioscorides
(c) Hippocrates
(d) Galen
74. Glycolysis is a
(a) Catabolic pathway
(b) Anabolic pathway
(c) Amphibolic pathway
(d) Fermentation pathway
75.Medical Termination of Pregnancy (MTP) Act was passed in the year
(a) 1963
(b) 1980
(c) 1971
(d) 1974
76. During diastole
(a) Blood leaves ventricle
(b) Blood leaves heart
(c) Blood enters in heart
(d) Blood enters lungs
77. Peri-winkle is a common name for:
(a) Digitalis purpurea
(b) Atropa belladonna
(c) Catheranthus roses
(d) Datura metal
78. Neuroleptics are used to treat:
(a) Neurosis
(b) Psychosis
(c) Narcolepsy
(d) Parkinsonian disorders
79. Minimum age limit for registration as pharmacist is
(a) 18 years
(b) 21 years
(c) 19 years
(d) 25 years
80. The membraneous covering of the heart is
(a) Meninges
(b) Pericardium
(c) Pleura
(d) Peritoneum

81. Vitamin D3 is also known as
(a) Ergocalciferol
(b) Cholecaliferol
(c) Calciferol
(d) Cholesterol
82. Preferred route of insulin is
(a) Oral
(b) Subcutanious
(c) Sublingual
(d) Enteric Coated tablets
83. Which disease is caused by virus
(a) Polio
(b) T.B.
(c) Malaria
(d) Leprosy
84. The competitive antagonist of Benzodiazepine receptors
(a) Flumazenil
(b) Picrotoxin
(c) Zolpidem
(d) Temazepam
85. Itai-Itai disease is caused by
(a) Mercury
(b) Lead
(c) Cadmium
(d) Iron
86. Therapeutic drug monitoring is done for
(a) Aspirin
(b) Chlorpromazine
(c) Lithium
(d) Statins
87. Tablet Dissolution Test is an indirect measure of
(a) Bioavailability
(b) Hardness
(c) Friability
(d) Tablet Shape
88. Causative agent of bacillary dysentery:
(a) Shigella
(b) E.Coli
(c) Proteus
(d) Vibrio

89. Disinfectant fluids come under
(a) Schedule O
(b) Schedule R
(c) Schedule S
(d) ScheduleE
90. The hypotensive effect of clonidine is due to its action on
(a) β -adrenergic receptor
(b) α -adrenergic receptor
(c) H2 -receptor
(d) H1 receptor
91. Drugs used to aid digestion in the git
(a) Pepsin
(b) Probucol
(c) Gugulipid
(d) Pectin
92. Furosemide is
(a) Loop diuretics
(b) Osmotic diuretics
(c) Thiazide diuretics
(d) Potassium sparing diuretics
93. Which of the following is communicable disease
(a) Diabetes
(b) Hypertension
(c) Kwashiorkor
(d) Diphtheria
94. Sweling factor is cricria for me purity of
(a) Acacia
(b) Tragacanth
(c) Guar
(d) Isopgol
95. Suppositories used for ear infection are called
(a) Rockets
(b) Cones
(c) Bougies
(d) Pessaries
96. Number of bones in skull are
(a) 18 bones
(b) 22 bones
(c) 25 bones
(d) 28 bones

97. On an average a normal healthy woman should gain about ….. kg of weight during
pregnancy
(a) 5 kg
(b) 12 kg
(c) 20 kg
(d) 30 kg
98. Dragendorff’s reagent is employed for the identification of
(a) Carbohydrates
(b) Alkaloids
(c) Flavonoids
(d) Proteins
99. Deficiency of vitamin C can lead to
(a) Dermatitis
(b) Lips fissure
(c) Scurvy
(d) Rickets
100. Dissolution of a drug particle is described by
(a) Noyes-Whitney equation
(b) Stock’s equation
(c) Drag’s equation
(d) None
101. Which of the following packaging material is protect the drug content against light
(a) Plastic containers
(b) Amber colored glass containers
(c) Both
(d) None
102. The salt intake per day should be kept to a limit of
(a) 1 gm daily
(b) 5 gm daily
(c) 10 gm daily
(d) 15 gm daily
103. Ribosomes helps in
(a) Protein synthesis
(b) Photosynthesis
(c) Lipid synthesis
(d) Respiration
104. Safest anti-tuberculosis drug in renal disease is
(a) Ethambutal
(b) Streptomycin
(c) Rifampicin
(d) Capreomycin

105. Anaphylactic shock occur due to,
(a) Allergic reactions
(b) Blood loss
(c) Spinal cord injury
(d) Infections
106. Choose the appropriate therapeutic use of imipramine
(a) Insomnia
(b) Epilepsy
(c) Bed wetting in children
(d) Mania
107. A substance used to measure the glomerular filtration rate is
(a) Insulin
(b) Inulin
(c) Diodrast
(d) Paraamino hippuric acid
108. Highest amount of solid content present in
(a) Ointment
(b) Gel
(c) Jellies
(d) Paste
109. The drug "ALISKERIN" belongs to which class of Antihypertensive Drugs
(a) ACE Inhibitor
(b) Angiotensin-II Antagonist
(c) Calcium Channel Blocker
(d) Renin Inhibitor
110. What is Action of digitalis
(a) Anti-emetic
(b) Analgesic
(c) Increase force of contraction of heart
(d) Negative ionotropic effect
111. Pellagra is due to the deficiency of
(a) Niacin
(b) Thiamine
(c) Vitamin B12
(d) Vitamin C
112. Cascade impactor is used for determination of
(a) Flash point
(b) Sedimentation rate
(c) Particle size
(d) Density of liquid

113. The plant which shows hypoglycemic effect due to indirect stimulation of insulin
secretion by pancreas is……..
(a) Strychnos nuxvomica
(b) Gingko biloba
(c) Gymnema sylvestre
(d) Lawsonia inermis
114. Dettol comes under
(a) Schedule N
(b) Schedule O
(c) Schedule P
(d) Schedule Q
115. Enzyme which is used in the treatment of leukaemia:
(a) Urokinase
(b) Streptokinase
(c) Asparginase
(d) Pepsin
116. Derivatisation of a sample in GC is carried out to
(a) Reduce polarity of the analytes
(b) Increase the detector response
(c) Increase volatility of the analytes
(d) All of the above
117. Virginian prune bark is known as
(a) Cinchona
(b) Wild cherry
(c) Kurchi
(d) Ashoka
118. The most effective antidote for belladonna poisoning is
(a) Neostigmine
(b) Physostigmine
(c) Pilocarpine
(d) Methacholine
119. Type of Rh antibody:
(a) IgM
(b) IgG
(c) IgE
(d) IgA
120. Myasthenia gravis is diagnosed with improved neuromuscular function by using
(a) Donepezil
(b) Edrophonium
(c) Atropine
(d) Pancuronium

121. Antidote for nicotine poisoning is
(a) Neostigmine
(b) Atropine sulphate
(c) Phentolamine
(d) Trimethaphan
122. Motif is represented by:-
(a) Commas repeated on the lattice
(b) 3D translational periodic arrangement of points
(c) Geometric shapes of lattice
(d) Centre of symmetry in lattice
123. LOSARTAN is
(a) Angiotensin II receptor antagonist
(b) Potent anti- hypotensive agent
(c) Calcium channel blocker
(d) Atrial fibrillating agent
124. An antitubercular drug that is a pyridine derivative is,
(a) Ethambutol
(b) Ethionamide
(c) Pyrazinamide
(d) Para-aminosalicylic acid
125. The phylum chordata is characterised by the presence of
(a) Spinal cord
(b) Notochord
(c) Nerve chord
(d) None of these

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