How dangerous is this really?
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1) Pain is a complex experience influenced by sensory, cognitive, and emotional factors rather than just tissue damage. 2) The brain evaluates threats and regulates protective responses like movement, immune function, and autonomic activity. 3) Higher-level cognitive and contextual factors can increase or decrease the perceived intensity of pain through descending modulation of the spinal cord.
How dangerous is this really?
- 1. (Understand &) Explain Pain Lorimer Moseley NHMRC Senior Research Fellow Prince of Wales Medical Research Institute, Sydney, Australia Senior Fellow The GAMFI project University of Oxford, UK © GL Moseley www.BodyInMind.com.au
- 2. Nociception is neither sufficient nor necessary for pain © GL Moseley www.BodyInMind.com.au
- 3. The relationship between nociception and pain is variable © GL Moseley www.BodyInMind.com.au
- 4. Pain Tissue danger pain Take action – remove danger © GL Moseley www.BodyInMind.com.au
- 6. Complex reasoning mechanisms based on experience, context, environment…MEANING © GL Moseley www.BodyInMind.com.au
- 7. Complex reasoning p ain mechanisms based on experience, context, environment…MEANING © GL Moseley www.BodyInMind.com.au
- 8. Complex reasoning mechanisms based on experience, context, environment…MEANING “How dangerous is this really?” © GL Moseley www.BodyInMind.com.au
- 9. Pain does not provide an accurate indication of tissue state – It makes us take action to promote our well-being (get out of danger!) © GL Moseley www.BodyInMind.com.au
- 10. Every represented byte can modulate Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley www.BodyInMind.com.au
- 11. Every represented byte can modulate Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley www.BodyInMind.com.au
- 12. Every represented byte can modulate Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley www.BodyInMind.com.au
- 13. Every represented byte can modulate Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley www.BodyInMind.com.au
- 14. Every represented byte can modulate Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley www.BodyInMind.com.au
- 15. multi-system outputs “How dangerous is this really?” © GL Moseley www.BodyInMind.com.au
- 16. Every represented byte can modulate Sum evaluative inputs = “It is not as dangerous as that” Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley www.BodyInMind.com.au
- 17. Every represented byte can modulate Sum evaluative inputs = “It is not as dangerous as that” Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley Descending inhibition www.BodyInMind.com.au
- 18. Every represented byte can modulate Sum evaluative inputs = “It is not as dangerous as that” Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley Descending inhibition www.BodyInMind.com.au
- 19. Every represented byte can modulate Sum evaluative inputs = “It is not as dangerous as that” Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley Descending inhibition www.BodyInMind.com.au
- 20. Every represented byte can modulate Sum evaluative inputs = “It is more dangerous that that” Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley www.BodyInMind.com.au
- 21. Every represented byte can modulate Sum evaluative inputs = “It is more dangerous that that” Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley Descending facilitation www.BodyInMind.com.au
- 22. Every represented byte can modulate Sum evaluative inputs = “It is more dangerous that that” Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley Descending facilitation www.BodyInMind.com.au
- 23. Every represented byte can modulate Sum evaluative inputs = “It is more dangerous that that” Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley Descending facilitation www.BodyInMind.com.au
- 24. Thanks Lorimer Moseley NHMRC Senior Research Fellow Prince of Wales Medical Research Institute, Sydney, Australia Senior Fellow The GAMFI project University of Oxford, UK © GL Moseley www.BodyInMind.com.au