Vieta's contributions to mathematics at the end of the 16th century marked a transition by establishing a strong foundation for algebra and developing symbolic notation, which differentiated between known and unknown variables. His work introduced principles such as the binomial formula and the connection between roots and coefficients, which were pivotal for future mathematicians. By emphasizing the need for homogeneity in equations and creating efficient notations, Vieta's approach ended medieval algebra and set the stage for modern mathematics.