This document summarizes a study on using hybrid endovascular and open surgical procedures to treat severe multi-level lower extremity arterial disease. 38 patients underwent 40 hybrid procedures between 2013-2015 that combined techniques like remote endarterectomy, stent placement, and bypass surgery. Initial technical success was 100% with mean ABI increase of 0.4. Primary patency rates at 12 months were 86.7% and limb salvage rates were 95%. The conclusion is that hybrid procedures provide an effective less invasive treatment for multi-level lower extremity atherosclerosis.