This document provides an overview of American football and discusses opportunities for statistical analysis and research. It describes the basic structure of the game and notes that while detailed play-by-play data exists, it has not been easily accessible for academic research. The document then discusses several areas where statistical methods could be applied, including evaluating individual player and team performance, developing models to assess strategy around decisions like fourth downs and extra points, and creating statistical ratings of teams. It argues more research is needed to better understand the game and inform coaching decisions.