Dr. Lluís Blanch Torra
Senior Critical Care
Former President of SEMICYUC
WFSICCM Council member
Director of Institut d’Investigació i
Innovació Parc Taulí I3PT
Cairo, 12 January 2017
ICU of the future & Information
technology
ICU of the future and Information Technology
Intensive Care Med 2016 DOI 10.1007/s00134-016-4525-y
Computer Driven Intensive Care
GeneticAnalysis
“Triage”
Structural & Physiological
Organ Analysis
Organ Reconstruction
and the brain?
ICU
of the
Future
by Sonia Touriño
THE PRECISION MEDICINEINITIATIVE
Mission statement:
To enable a new era of medicine through research, technology, and policies that empower
patients, researchers, and providers to work together toward development of individualized
care.
- President Obama, January 30, 2015
https://www.whitehouse.gov/precision-medicine
Syndromic Medicine: Guidelines
Precision
Medicine
Personalized Medicine
Protocols for Specific Subgroups
Phenotype Identification:
Personalized Medicine for ARDS Patients?
Subphenotypes of ARDS:
Severity: oxygenation impairment & PEEP response
Biology: epitelial vs endothelial injury & inflammation
Aetiology: pneumonia, sepsis, disease-like ARDS
Timing: early, late
Imatge appearence: diffuse, local
Combinations of above
Beitler JR et al. Intensive Care Med 2016;42:756-67
Differencesin categoricalvariables
based on phenotype assignment
Differencesin the standardized values of each variable by
phenotype on the y-axis,with the individualcontinuous
variables alongthe x-axis
JAMA Published onlineSeptember 26, 2016
Invest in and apply the promise of cognitive
computing. With rapidly expanding computing
capability to integrate, process, and assess very large
databases, opportunities develop for accelerated
learning, understanding individual variation, and
developing predictive modeling.
Sources of Big Data
of course in the ICU
Iwashyna TJ & Liu V
AnnalsATS 2014;11:1130-5
5Vs: value, volume, variety,
velocity, veracity
Turner MC et al AJRCCM Articles in Press. Published on 17-December-2015
Ware LB et al AJRCCM Articles in Press. Published on 17-December-2015
Long-Term Ozone Exposure & Respiratory Diseases
Drivers of “Big Data” in Medicine
Biological Processes Are Better Understood
human genome, genetics & response to therapies,
individualised treatment decisions
Growth of Digitised Information
images, reports, lab. results, monitoring sensors
monitors, ventilators smartphones, Fitbit
Cloud-Based IT Solutions
data unified & available in space and time, novel algorithms &
machine learning
Individual Patients = Decision Support
Whole Populations = Population Health
Mathias Goyen 2016
Information overload
ICU ITs
Lack of Information !
CCM 2013; 41:1502–1510
Physicians use a limited number of clinical information
concepts at the time of patient admission to the ICU.
The electronic medical record contains an abundance
of unused data.
Information
Overload in ICU
Reported frequency of utilization of data
elements in EMR
HR
SpO2
RR
MAP
The Connectivity Envelope Includes Hardware
for Source Tracking and Data Acquisition
Halpern NA. Chest 2014;145:903
ICU of the future and Information Technology
Potentially injurious ventilator settings
for 1 h during the first 3 days of MV
Asynchrony Index & Sedation Scale
Representative Patient
0 100 200 300 400 500 600 700 800 900 1000 1100
0
10
20
30
40
50
AI
SAS
Hour
Hours
AI
SAS
Summary:
ICU Informatics & Big Data:
Association
Patients ID or patient location
Interoperability
Data generated by one device can be
accessed and used by another
Time Synchronization
Vital for maintaining an electronic flow sheet
and tracking alarms and responses
Medical Devices are Informatics Platforms
Integration with ICU middleware
Virtual reality (VR) typically refers to computer technologies that
se software to generate realistic images, sounds and other sensations
that replicate a real or imaginary environment, and simulate a user's
physical presence in this environment, by enabling the user to interact
with this space and any objects depicted therein using
specialized display screens or projectors and other devices.
From Wikipedia
Journal of Critical Care (2011)
Virtual Reality
Early Neurocognitive Rehabilitation in Intensive Care
Project funded by La Marató TV3 2010
Multidisciplinary Team
ENRIC at ClinicalTrials.Gov
Philips Dubai 2016
Internet of Things
Smart Alerts Linked to Domotics
Clinic BCN
Vital signs display
A middleware (Better Care®) provides connectivity to HIS (SAP)
Opportunities for the Future of Health
(of course in the ICU)
Joint enterprise of patients & health professionals & others
(cross fertilization) using digital technologies: big data,
connectivity and artificial intelligence
New forms of technology: sensors and mobile apps for
continuous monitoring, early interventions and immediate
corrections
New players: Small start ups (drive innovation) & Google
and Apple (services providers) instead of big manufacturers
(marketing and distribution): collaboration versus competition
Finding successful business models: adding services to the
portfolio, system efficiencies and long term value
In the ICU we must go from
Volume to Value !!
ASYNICU group is
supported by:
AVANZA, FIS, MaratoTV3,
CIBERes, I3Parc Tauli and
Better Care S.L.
Thanks to Members of ASYNICU Group!!

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ICU of the future and Information Technology

  • 1. Dr. Lluís Blanch Torra Senior Critical Care Former President of SEMICYUC WFSICCM Council member Director of Institut d’Investigació i Innovació Parc Taulí I3PT Cairo, 12 January 2017 ICU of the future & Information technology
  • 3. Intensive Care Med 2016 DOI 10.1007/s00134-016-4525-y Computer Driven Intensive Care GeneticAnalysis “Triage” Structural & Physiological Organ Analysis Organ Reconstruction and the brain?
  • 5. THE PRECISION MEDICINEINITIATIVE Mission statement: To enable a new era of medicine through research, technology, and policies that empower patients, researchers, and providers to work together toward development of individualized care. - President Obama, January 30, 2015 https://www.whitehouse.gov/precision-medicine
  • 6. Syndromic Medicine: Guidelines Precision Medicine Personalized Medicine Protocols for Specific Subgroups
  • 7. Phenotype Identification: Personalized Medicine for ARDS Patients? Subphenotypes of ARDS: Severity: oxygenation impairment & PEEP response Biology: epitelial vs endothelial injury & inflammation Aetiology: pneumonia, sepsis, disease-like ARDS Timing: early, late Imatge appearence: diffuse, local Combinations of above Beitler JR et al. Intensive Care Med 2016;42:756-67
  • 8. Differencesin categoricalvariables based on phenotype assignment Differencesin the standardized values of each variable by phenotype on the y-axis,with the individualcontinuous variables alongthe x-axis
  • 9. JAMA Published onlineSeptember 26, 2016 Invest in and apply the promise of cognitive computing. With rapidly expanding computing capability to integrate, process, and assess very large databases, opportunities develop for accelerated learning, understanding individual variation, and developing predictive modeling.
  • 10. Sources of Big Data of course in the ICU Iwashyna TJ & Liu V AnnalsATS 2014;11:1130-5 5Vs: value, volume, variety, velocity, veracity
  • 11. Turner MC et al AJRCCM Articles in Press. Published on 17-December-2015 Ware LB et al AJRCCM Articles in Press. Published on 17-December-2015 Long-Term Ozone Exposure & Respiratory Diseases
  • 12. Drivers of “Big Data” in Medicine Biological Processes Are Better Understood human genome, genetics & response to therapies, individualised treatment decisions Growth of Digitised Information images, reports, lab. results, monitoring sensors monitors, ventilators smartphones, Fitbit Cloud-Based IT Solutions data unified & available in space and time, novel algorithms & machine learning Individual Patients = Decision Support Whole Populations = Population Health Mathias Goyen 2016
  • 14. CCM 2013; 41:1502–1510 Physicians use a limited number of clinical information concepts at the time of patient admission to the ICU. The electronic medical record contains an abundance of unused data. Information Overload in ICU Reported frequency of utilization of data elements in EMR HR SpO2 RR MAP
  • 15. The Connectivity Envelope Includes Hardware for Source Tracking and Data Acquisition Halpern NA. Chest 2014;145:903
  • 17. Potentially injurious ventilator settings for 1 h during the first 3 days of MV
  • 18. Asynchrony Index & Sedation Scale Representative Patient 0 100 200 300 400 500 600 700 800 900 1000 1100 0 10 20 30 40 50 AI SAS Hour Hours AI SAS
  • 19. Summary: ICU Informatics & Big Data: Association Patients ID or patient location Interoperability Data generated by one device can be accessed and used by another Time Synchronization Vital for maintaining an electronic flow sheet and tracking alarms and responses Medical Devices are Informatics Platforms Integration with ICU middleware
  • 20. Virtual reality (VR) typically refers to computer technologies that se software to generate realistic images, sounds and other sensations that replicate a real or imaginary environment, and simulate a user's physical presence in this environment, by enabling the user to interact with this space and any objects depicted therein using specialized display screens or projectors and other devices. From Wikipedia
  • 21. Journal of Critical Care (2011)
  • 23. Early Neurocognitive Rehabilitation in Intensive Care Project funded by La Marató TV3 2010 Multidisciplinary Team ENRIC at ClinicalTrials.Gov
  • 25. Internet of Things Smart Alerts Linked to Domotics Clinic BCN
  • 26. Vital signs display A middleware (Better Care®) provides connectivity to HIS (SAP)
  • 27. Opportunities for the Future of Health (of course in the ICU) Joint enterprise of patients & health professionals & others (cross fertilization) using digital technologies: big data, connectivity and artificial intelligence New forms of technology: sensors and mobile apps for continuous monitoring, early interventions and immediate corrections New players: Small start ups (drive innovation) & Google and Apple (services providers) instead of big manufacturers (marketing and distribution): collaboration versus competition Finding successful business models: adding services to the portfolio, system efficiencies and long term value In the ICU we must go from Volume to Value !!
  • 28. ASYNICU group is supported by: AVANZA, FIS, MaratoTV3, CIBERes, I3Parc Tauli and Better Care S.L. Thanks to Members of ASYNICU Group!!