This document discusses using Orthanc, an open-source medical imaging software, to manage images from a multi-site neuroscience PET study involving 600 subjects across 4 academic medical centers. Orthanc was chosen for its flexibility, scalability, and ability to accommodate the high variability across sites and scanners. It allows uploading images via DICOM and a web interface, and can be deployed quickly in the cloud for encrypted transport and storage. The implementation discusses using Orthanc on AWS with encryption and access controls to work towards HIPAA compliance. It also addresses challenges of reconciling errors and multiple identities that naturally occur across dispersed medical research studies.