Simone Soldateschi discusses immutable infrastructure systems in AWS. He advocates for baking application deployments into AMIs for simplicity and repeatability. This avoids complicated configuration management and allows deploying pre-tested environments. He demonstrates a process for baking AMIs, including starting a vanilla EC2 instance, configuring and deploying an app, exporting the result as a new AMI, then discarding the instance. This produces immutable, versioned environments that are easy to deploy and maintain across environments.