The document summarizes the key findings of the IPCC Fourth Assessment Report regarding the observed and projected impacts of climate change. It finds that natural and human systems are already being affected by regional climate changes. Impacts are expected to increase substantially with further warming, including reduced agricultural productivity, heightened water insecurity, increased extreme weather events, ecosystem collapse, and greater health risks. Adaptation can help reduce vulnerabilities in the short-term, but mitigation is needed to avoid the most severe consequences of climate change.