This document discusses implementing HIV and STI programs with key populations. It outlines the UNAIDS 90-90-90 strategy targets and summarizes WHO guidelines for HIV prevention, diagnosis, treatment and care for key populations like sex workers, men who have sex with men, people who inject drugs, and transgender people. The guidelines recommend interventions like condoms, pre-exposure prophylaxis, sterile syringes, and empowering key populations to claim their human rights. Community empowerment and removing stigma and discrimination are essential to effective programs.