1. Gastrointestinal infections are a major global cause of illness and death, with acute gastroenteritis second only to cardiovascular disease worldwide in mortality. 2. Helicobacter pylori is a common cause of gastritis and peptic ulcer disease. It has also been linked to gastric cancer through a sequence of events from acute to chronic gastritis. 3. Foodborne illnesses remain an important public health problem, causing millions of cases annually in the US despite efforts to improve food safety. The major syndromes of food poisoning vary based on the causative organism and time of symptom onset.