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Epidemiology
Epidemiology
Epidemiology is the basic science of community Medicine.
‘Epi’ – among ‘demos’ – people ‘logos’ – study
Epidemiology means the study among people.
Definition	of	Epidemiology	
•As per Perkins (1873) It is that branch of science
which treats of epidemics.
•As per Frost (1927) it is the science of mass
phenomenon of infectious disease.
•As per Greenwood (1934) The study of any
disease as a mass phenomena.
•As per MacMohan (960) The study of the
distribution and determinants of disease frequency
in man.
Definition	of	Epidemiology
As per John M. Last (1988) Epidemiology is the
study of the distribution and determinants of
health related states or events in specified
populations, and the application of this study to
the control of health problems.
Epidemiology often more concerned with the well-
being of society as a whole, than with the well-
being of individuals.
In these definition three components are common.
•Study of the disease frequency (frequency of
disease, disability or death and summarizing in the
form of rates and ratios).
•Study of the distribution (pattern of disease i.e.
time, place, person).
•Study of the determinants (underlying cause or risk
factors).
Components	of	Epidemiology
1)	Disease	frequency		(rate	or	ratio)	
2)	Distribution	of	disease	(Time,	place	&	
person)	
3)	Determinants	of	disease	(Cause	or	risk	
factor)
• DISTRIBUTION
• TIME	:- WHEN	OCCURRED
• PLACE	:- WHERE	IT	OCCURRED
• PERSON	:- AGE,	SEX,	RACE,	OCCUPATION
DETERMINANTS	
(CAUSES	&	FACTORS	THAT	INFLUNCE	THE	RISK	OF	DISEASE	)
• HOST	FACTORS:-
Factors	that	determine	the	host	exposure	:- age,	sex,	
genetic,	physiology,	nutritional	status,	constitutional	
make	up,	previous	immunological	experience,	
occupation.
Aims	of	Epidemiology	
According	to	IEA	(International	Epidemiological	Association),
1. To	describe	the	distribution	and	magnitude	of	health	and	disease	
problems	in	human	population.
2. To	identify	the	aetiological	factors	and	risk	factors	in	pathogenesis	of	
disease.
3. To	provide	data	essential	to	planning	implementation	and	evaluation	
of	services	for	prevention,	control	and	treatment	of	diseases	and	
setting	of	priorities	among	the	services.
The	ultimate	aim	of	epidemiology	is	to	lead	effective	action
1. To	eliminate	or	reduce	health	problems	or	its	consequences.	
2. To	promote	the	health	and	well	being	of	society	as	a	whole.
Difference	of	Epidemiology	&	Clinical	Medicine
CLINICAL MEDICINE EPIDEMIOLOGY
1. The unit of study is case or cases 1. Unit of study is the population
2. Concerned with disease in
person
2. Concerned with disease pattern
in population bothsick &
healthy
3. Clinician gives diagnosis and
treatment & prognosis of the
case. The diagnostic techniques
are refined and modified
3. Epidemiologist is interested in
the source of infection,mode of
spread & trend of disease.
Evaluates the outcome of
preventive & therapeutic
measure & give clue to
administratorfor effective
management
4. The patient goes to the clinician. 4. Epidemiologist goes to the
community.
Epidemiological	Approach
The	epidemiological	approach	to	the	problems	of	health	and	
disease	is	based	on	two	major	foundations
• Asking	Questions	
• Making	comparisons
Asking	Questions	
Epidemiology	has	been	defined	as	“a	means	of	
learning	or	asking	questions…	and	getting	
answers	that	lead	to	further	questions.”
Related	to	health	Events
a. What	is	the	problem?
b. What	is	its	Magnitude?
c. Where	did	it	happen?
d. When	did	it	happen?
e. Who	are	affected?
f. Why	did	it	happen?
Cont……
• Questions	Related	to	Health	Action
a. What	can	be	done	to	reduce	the	
problem?
b. How	can	it	be	prevented?
c. What	action	should	be	taken	by	the	
community?	By	the	Health	Services?	By	
other	sectors?
d. What	resources	are	required?
e. How	are	the	activities	to	be	organized?
f. What	difficulties	may	arise	in	
implementation?
Making	Comparisons
• The	basic	approach	in	epidemiology	is	to	make	comparisons	and	draw	
inferences.
• Comparison	between	two	or	more	groups
(one	group	having	disease	or	exposed	to	risk	factors	and	the	other	group	
not	having	disease	or	not	exposed	to	risk	factors,	or	comparison	
between	two	individuals).
• Epidemiologist	weighs,	balances	and	contrasts.
Uses	of	Epidemiology	
1. In	health	care	management	
• Making	Community	diagnosis	
• Planning	and	evaluation	of	health	services.	
• Developing	health	policies.	
2. Understanding	disease	process
• Studying	natural	history	of	disease.
• Searching	for	causes	and	risk	factors.
• Historic	studies	of	rise	&	fall	of	disease.
• Identification	of	syndromes.
Uses	of	Epidemiology
3.		Uses	in	public	health	practice
• Investigation	of	epidemics	
• Surveillance	of	disease
• Making	projection	for	future
• Formulating	medical	teaching	curricular	
4.		Assisting	in	Clinical	Practice
• Assessing	 effectiveness	of	treatment	modalities	
• Assessing	 effectiveness	of	preventive	modalities	
• Studying	prognostic	factor	
• Studying	effectiveness	 of	diagnostic	modalities
• Assisting	in	clinical	decision	making	
• Indispensable	 for	basic	planning,	conducting	and	analysing	clinical	research
DISEASE	FREQUENCY
RATE	:
Signifies	speed	or	the	frequency	of	occurrence	per	unit	of	
time.
•The	numerator	is	a	part	of	the	denominator.	
Eg.Notification	rate	of	new	sputum	smear	+ve	cases	=	New	
ss	+ve	/	100,000	population.(38	in	2002)
•Cure	rate	:No.	of	cases	cured x100
No.	Of	cases	under	Trt.
RATIO	:A	number	or	quantity	of	one	item	in	comparision	to	
the	other.
Both	the	items	are	not		a	part	of	each	other.
Eg.		Sex	ratio
1. New	smear	+ve	:	New	smear	-ve
2. New	smear	+ve	:	Extra	pulmonary
3. Non	seriously	ill	extra	pulm.	:Seriously	ill	extra	pulm.
PROPORTION	:Measurement	of	the	size	of	a	part	out	of	
the	whole,	usually	the	whole	taken	as	100.
If	the	fraction	is	too	small,	the	base	can	be	1000	or	any	
10x.
Numerator	is	always	a	part	of	a	denominator.
Terminology	used	in	Epidemiology
Epidemic	– The	unusual	occurenceof	disease,	specific	health	
related	behaviour	(eg.	Smoking)		or	other	health	related	
events	(eg.	Traffic	accidents)	in	a	community	or	region	clearly	
in	excess	of	“expected	occurence.”
Endemic	– constant	presence	of	a	disease	or	infectious	agent	
within	a	given	geographic	area	or	population	group,	without	
importation	from	outside	throughout	the	year	in	certain	parts	
of	country.
Sporadic	– Scattered	outbreaks	of	infectious	disease	in	
different	parts.
Pandemic	– An	epidemic	usually	affecting	a	large	proportion	of	
population	occurring	over	a	wide	geographic	area.
Exotic	– Infection	is	imported	from	outside.
Zoonoses	– Infectious	disease	of	animals	transmitted	to	man.	
Eg.	Rabies,	plague
Carrier	– A	person	or	animal	who	harbouring	specific	
infectious	agent	without	showing	signs	and	symptoms	of	
the	disease.
Communicable	disease	– Illness	transferred	directly	or	
indirectly	from	the	sick	to	the	healthy	person.	
Surveillance	– The	continuous	scrutiny	of	the	factors	that	
determine	the	occurrence	and	distribution	of	disease	and	
other	conditions	of	ill	health.
Eradication	– Termination	of	all	transmission	of	infection	by	
extermination	of	infectitious	agent	through	surveillance	and	
containment.

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Introduction to epidemiology