1. Ischemic mitral regurgitation occurs after a myocardial infarction results in segmental wall motion abnormalities and significant coronary artery disease in the territory supplying the abnormal wall motion, but with structurally normal mitral valve leaflets.
2. The papillary muscles that connect to the mitral valve leaflets receive their blood supply from the left anterior descending and right coronary arteries and can be damaged during a myocardial infarction.
3. Damage to the papillary muscles from a myocardial infarction can lead to mitral regurgitation, with symptoms ranging from dyspnea and fatigue in the acute setting to heart failure in the chronic setting.