Off-the-shelf software refers to commercially available software sold for common computing tasks, while custom-designed software is created to meet unique business needs. Some key differences are that off-the-shelf software is readily available for purchase online or in stores, has predefined system requirements, and usually cannot be returned once opened. In contrast, custom software is developed internally or by third-party vendors to address needs not met by existing options and can provide businesses a competitive advantage. Both approaches play important roles in software acquisition.