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Piers Pepperell & Alastair Caygill



JOHNES DISEASE PROJECT
   – 1ST YEAR RESULTS
What is it?
• It’s a contagious bacterial disease of the bovine
  intestine
• Slow growing bacteria that usually takes around
  3-7 years to start causing problems
• Causes a slow thickening of the intestinal wall =>
  reduced absorption => less nutrient uptake
• Causes reduced immunity to other conditions,
  reduced growth rates and increased culling rates
• Eventually ends as a terminal scour
• No treatment and no recovery
Reduces Lifetime performance
• Cows give >2000kgs less
  milk in a lifetime         • Causes financial loss by
  causing decreased calf     1. Loss of carcass value of
  growth rates                  the dam
• 5 X more likely to be      2. Decreased calf growth
  lame                          rates
• 2 X more likely to have    3. Loss of premium from
  mastitis                      high health status of
• 2 X more likely to have       pedigree herds
  digestive or respiratory
  disease
Usually subclinical disease
• Many farms may never have seen a case
  because infected animals are culled for poor
  performance or fertility before they start to
  show symptoms
• For this reason if you have a clinical case,
  there may well be several more subclinical
  cows in your herd (some estimates are 10-20
  subclinical cases for every clinical case)
Farms which had seen a case previous
     to the start of the project
     Beef farms         Dairy farm




                  Yes                Yes
                  No                 No
How is it spread?


                                                             Faeces
                                                             contaminating
                                                             calves/ udders
Colostrum and milk              10-40 % in utero
                                infection
                                depending on
                                level of infection




 Carriers shed intermittently in times of stress, shedding
 more and more as the disease advances
Main risk areas
• Contaminated calving
  areas – dung gets onto
  teats of non infected cow
  and is consumed by calf
• Cross suckling
• Feeding colostrum from
  another cow
• Hygiene usually better at
  pasture so housing is
  main area of spread
Other sources of infection
•   Bought in Cows, Bulls and replacements
•   Standing water sources – small lakes, ponds
•   Slurry from other farms
•   Sheep/Goats
•   Rabbits?
Susceptibility decreases with age
• When a calf is born it has a
  large number of areas in it’s
  gut called Peyers Patches. Their
  job is to allow antibodies to be
  absorbed into the blood from
  the colostrum
• These shrink over time until
  they have gone by around
  10mths of age
• It is through these that the
  Johnes enters the calf though
  colostrum, milk or dung
  consumed by the calf
• 80% of Johnes infections occur
  in the 1st month of life
Main spread area
• It is a shit into mouth
  disease. A carrier will
  shit onto the
  bedding, onto feed
  areas and even directly
  onto calves.
• A “super shedder” can
  discharge enough
  bacteria in 24 hours to
  infect 50000 calves
How can we test for it?
• The closer the animal comes to developing
  symptoms, the more sensitive the tests become. This
  means testing is ineffective under 2 years of age.
• Test the dung. This is the best test but quite expensive
• Blood test. This will pick up around 50% of infected
  cows. Best to do it as close to calving period as possible
  as increased stress increases the chance of picking it up
• Better to think of negative cows as “low risk of spread”
  cows
• If there is any risk the animal might be a carrier e.g.
  born to a positive mother, they should be treated as
  high risk until proven otherwise
Which animals to test?
• Regular quarterly whole herd samples Most reliable but
  very expensive

• Regular whole herd annual sample fairly reliable, more
  affordable and helps management decisions

• Whole herd individual sample useful but can give a false
  sense of security if not done regularly

• 30 cow screen okay start but may well miss some positives

• Individual/cull cows least reliable, very random
What we found in our 1st year
  Beef farms                 Dairy farms




                Positive                   Positive
               animals                     animals
               found                       found
               No positive                 No positive
               animals                     animals
               found                       found
Numbers on each farm
               Testing positive
16
14
12
10
8
                                  Testing positive
6
4
2
0
     B           D
• Positives were rebled a month later
• Double positives were then dung tested
  if requested
• Several blood positives have been dung
  negative. These are treated as medium
  or high risk depending on the farm
  history
• However we have now done the second
  year testing on 6 beef herds. Only 1 of
  them had positives last year and this
  year 5 out of the 6 have had positives!
What can you do to prevent Johnes
    disease becoming a problem
• Nothing – risky
• Test a few – might give you a false sense of
  security
• Test whole herd and cull – this has been
  shown to only reduce the disease level very
  slowly
• Test, cull and make changes to stop the spread
  – shown to be the most effective
How to reduce spread of Johnes in
        infected herd– low level
•   Clean calving areas-
    well bedded
•   Calve cows outside
•   Test all animal prior to
    calving and remove
    test positive and
    clinical cows early
•   Only feed colostrum
    taken from a young
    negative cow
Additional changes to reduce the spread of
 Johnes in medium to high infected herd
                     •   Bleed everything prior
                         to calving period.
                     •   Separate infected and
                         non infected cows into
                         two groups if
                         prevalence is high
                     •   Source replacements
                         from low prevalence
                         herds or low prevalence
                         groups
                     •   Ensure the last calf
                         from test positive
                         animals are not kept as
                         replacement breeding
                         stock
Environmental controls
• Keep cows and their
  environment clean and free
  from faecal
  contamination, especially
  during calving period and
  first 6months of calves’ lives
• Prevent faecal
  contamination of feed and
  water supplies.
• Keep feed and water
  troughs clean
• Provide mains water and
  fence off other water
  sources
Environmental controls
           • Spread dung or slurry on
             arable land, OR
           • Do not graze youngstock
             for at least 1 year on
             ground that has had dung
             or slurry spread on it
           • Avoid co-grazing
             youngstock with other
             livestock that can be
             infected with Johnes
           • Control rabbits
Any Questions?

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Johnes disease beef farm walk presentation

  • 1. Piers Pepperell & Alastair Caygill JOHNES DISEASE PROJECT – 1ST YEAR RESULTS
  • 2. What is it? • It’s a contagious bacterial disease of the bovine intestine • Slow growing bacteria that usually takes around 3-7 years to start causing problems • Causes a slow thickening of the intestinal wall => reduced absorption => less nutrient uptake • Causes reduced immunity to other conditions, reduced growth rates and increased culling rates • Eventually ends as a terminal scour • No treatment and no recovery
  • 3. Reduces Lifetime performance • Cows give >2000kgs less milk in a lifetime • Causes financial loss by causing decreased calf 1. Loss of carcass value of growth rates the dam • 5 X more likely to be 2. Decreased calf growth lame rates • 2 X more likely to have 3. Loss of premium from mastitis high health status of • 2 X more likely to have pedigree herds digestive or respiratory disease
  • 4. Usually subclinical disease • Many farms may never have seen a case because infected animals are culled for poor performance or fertility before they start to show symptoms • For this reason if you have a clinical case, there may well be several more subclinical cows in your herd (some estimates are 10-20 subclinical cases for every clinical case)
  • 5. Farms which had seen a case previous to the start of the project Beef farms Dairy farm Yes Yes No No
  • 6. How is it spread? Faeces contaminating calves/ udders Colostrum and milk 10-40 % in utero infection depending on level of infection Carriers shed intermittently in times of stress, shedding more and more as the disease advances
  • 7. Main risk areas • Contaminated calving areas – dung gets onto teats of non infected cow and is consumed by calf • Cross suckling • Feeding colostrum from another cow • Hygiene usually better at pasture so housing is main area of spread
  • 8. Other sources of infection • Bought in Cows, Bulls and replacements • Standing water sources – small lakes, ponds • Slurry from other farms • Sheep/Goats • Rabbits?
  • 9. Susceptibility decreases with age • When a calf is born it has a large number of areas in it’s gut called Peyers Patches. Their job is to allow antibodies to be absorbed into the blood from the colostrum • These shrink over time until they have gone by around 10mths of age • It is through these that the Johnes enters the calf though colostrum, milk or dung consumed by the calf • 80% of Johnes infections occur in the 1st month of life
  • 10. Main spread area • It is a shit into mouth disease. A carrier will shit onto the bedding, onto feed areas and even directly onto calves. • A “super shedder” can discharge enough bacteria in 24 hours to infect 50000 calves
  • 11. How can we test for it? • The closer the animal comes to developing symptoms, the more sensitive the tests become. This means testing is ineffective under 2 years of age. • Test the dung. This is the best test but quite expensive • Blood test. This will pick up around 50% of infected cows. Best to do it as close to calving period as possible as increased stress increases the chance of picking it up • Better to think of negative cows as “low risk of spread” cows • If there is any risk the animal might be a carrier e.g. born to a positive mother, they should be treated as high risk until proven otherwise
  • 12. Which animals to test? • Regular quarterly whole herd samples Most reliable but very expensive • Regular whole herd annual sample fairly reliable, more affordable and helps management decisions • Whole herd individual sample useful but can give a false sense of security if not done regularly • 30 cow screen okay start but may well miss some positives • Individual/cull cows least reliable, very random
  • 13. What we found in our 1st year Beef farms Dairy farms Positive Positive animals animals found found No positive No positive animals animals found found
  • 14. Numbers on each farm Testing positive 16 14 12 10 8 Testing positive 6 4 2 0 B D
  • 15. • Positives were rebled a month later • Double positives were then dung tested if requested • Several blood positives have been dung negative. These are treated as medium or high risk depending on the farm history • However we have now done the second year testing on 6 beef herds. Only 1 of them had positives last year and this year 5 out of the 6 have had positives!
  • 16. What can you do to prevent Johnes disease becoming a problem • Nothing – risky • Test a few – might give you a false sense of security • Test whole herd and cull – this has been shown to only reduce the disease level very slowly • Test, cull and make changes to stop the spread – shown to be the most effective
  • 17. How to reduce spread of Johnes in infected herd– low level • Clean calving areas- well bedded • Calve cows outside • Test all animal prior to calving and remove test positive and clinical cows early • Only feed colostrum taken from a young negative cow
  • 18. Additional changes to reduce the spread of Johnes in medium to high infected herd • Bleed everything prior to calving period. • Separate infected and non infected cows into two groups if prevalence is high • Source replacements from low prevalence herds or low prevalence groups • Ensure the last calf from test positive animals are not kept as replacement breeding stock
  • 19. Environmental controls • Keep cows and their environment clean and free from faecal contamination, especially during calving period and first 6months of calves’ lives • Prevent faecal contamination of feed and water supplies. • Keep feed and water troughs clean • Provide mains water and fence off other water sources
  • 20. Environmental controls • Spread dung or slurry on arable land, OR • Do not graze youngstock for at least 1 year on ground that has had dung or slurry spread on it • Avoid co-grazing youngstock with other livestock that can be infected with Johnes • Control rabbits