June 1, 2011 Senology.org Newsletter
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The newsletter provides information on upcoming conferences, recent literature on breast cancer and other topics, and a commentary on the use of a 21-gene recurrence score assay to guide treatment decisions for early-stage breast cancer. It also lists literature on topics like coffee consumption and breast cancer risk, neoadjuvant chemotherapy for triple-negative breast cancer, and a historical account of breast cancer surgery.
![Senology Newsletter http://www.senology.org/newsletter/Newsl_Jun2011.htm
Senology.org - Newsletter
International Senologic and Oncologic Scientific Community
"Connecting specialists worldwide"
Editor-in-chief: Gian Paolo Andreoletti, MD
Subscribe Unsubscribe Contact Back Issues
Connecting Specialists Worldwide
Join us on Facebook®, Twitter®, YouTube®, LinkedIn®, SlideShare®, Flickr® and Doctorsbook® and share
informations, opinions and suggestions. Check out Senology.org Newspaperand follow our RSS feeds for real-time
updates
Literature Selection
Li J et al.: "Coffee consumption modifies risk of estrogen-receptor negative breast cancer", Breast
Cancer Res. 2011 May 14;13(3):R49. [Epub ahead of print]
Elkin EB et al.: "Characteristics and Outcomes of Breast Cancer in Women With and Without a
History of Radiation for Hodgkin's Lymphoma: A Multi-Institutional, Matched Cohort Study", J Clin
Oncol. 2011 May 16. [Epub ahead of print]
Kirsh VA et al.: "Tumor Characteristics Associated With Mammographic Detection of Breast Cancer
in the Ontario Breast Screening Program", J Natl Cancer Inst. 2011 May 3. [Epub ahead of print]
Ohsumi S et al.: "Detection of isolated ipsilateral regional lymph node recurrences by
F18-fluorodeoxyglucose positron emission tomography-CT in follow-up of postoperative breast
cancer patients"
Freedman AN et al.: "Benefit/Risk Assessment for Breast Cancer Chemoprevention With Raloxifene
or Tamoxifen for Women Age 50 Years or Older", J Clin Oncol. 2011 May 2. [Epub ahead of print]
Hatzis C et al.: "A genomic predictor of response and survival following taxane-anthracycline
chemotherapy for invasive breast cancer", JAMA. 2011 May 11;305(18):1873-81
Pfeiler G et al.: "Impact of Body Mass Index on the Efficacy of Endocrine Therapy in Premenopausal
Patients With Breast Cancer: An Analysis of the Prospective ABCSG-12 Trial", J Clin Oncol. 2011
May 9. [Epub ahead of print]
Nedumpara T et al.: "Impact of immediate breast reconstruction on breast cancer recurrence and
survival", Breast. 2011 May 19. [Epub ahead of print]
Petit JY et al.: "Locoregional recurrence risk after lipofilling in breast cancer patients", Ann Oncol.
2011 May 24. [Epub ahead of print]
Arver B et al.: "Bilateral Prophylactic Mastectomy in Swedish Women at High Risk of Breast Cancer:
A National Survey", Ann Surg. 2011 Jun;253(6):1147-1154
1 di 3 01/06/2011 16:17](https://image.slidesharecdn.com/june12011-senology-orgnewsletter-110601092011-phpapp02/85/June-1-2011-Senology-org-Newsletter-1-320.jpg)
![Senology Newsletter http://www.senology.org/newsletter/Newsl_Jun2011.htm
Ono M et al.: "Tumor-infiltrating lymphocytes are correlated with response to neoadjuvant
chemotherapy in triple-negative breast cancer", Breast Cancer Res Treat. 2011 May 12. [Epub ahead
of print]
Comment
"The 21-gene assay in early-stage breast cancer" - David B. Geffen, Department of Oncology, Soroka
University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev. Beer
Sheva, Israel
"The prognosis of early stage estrogen receptor positive breast cancer is generally very good and the
average benefit of adding adjuvant chemotherapy to adjuvant endocrine therapy is small but exists. The
21-gene recurrence score (RS) assay has been validated through the use of retrospective studies as
prognostic of distant disease recurrence and predictive of the benefit of adding chemotherapy. We evaluated
the impact of using the test in our practice, a university based group of oncologists who have a uniform
treatment policy. For a high risk RS, chemotherapy was recommended, for a low risk, endocrine therapy
alone and for intermediate risk, treatment based on traditional clinicopathologic factors with help from
Adjuvant!on-line. In this retrospective analysis of 135 patients whom we tested with the 21-gene RS between
2006- 2009, in 25 % of patients we changed recommendation after obtaining results. Most changes were in
the direction of not giving chemotherapy (70% of changes). A somewhat surprising finding was that 29 % of
the 49 patients for whom we recommended chemotherapy after obtaining the RS, refused chemotherapy. The
RS substantially reduced the number of patients receiving chemotherapy but we need to improve our
patients' understanding of the implications of the test"
(Comment on: Geffen DB et al.: "The impact of the 21-gene recurrence score assay on decision
making about adjuvant chemotherapy in early-stage estrogen-receptor-positive breast cancer in an
oncology practice with a unified treatment policy", Ann Oncol. 2011 Mar 1. [Epub ahead of print])
Healthcare Companies News
Genomic Health announces positive preliminary results of Oncotype DX® study in DCIS breast
cancer
Share your opinions and comments on LinkedIn®
Fragments of History
Charles H. Moore:, Royal Medical and Chirugical Society, London, 1867: “On the influence of inadequate
operations on the theory of cancer", Med Chir Trans, 1867, 32: 245-80: “Taught without doubt by
foregoing failures, our surgical ancestors adopted a method of operating which might well have been
expected to prove effectual against a local recurrence of the disease. They transfixed the base of the
mamma, and, raising it with ligatures, swept off the whole organ, together with all the skin that covered it.
The proceeding had a barbarous appearance enough, but it was promising; and, if their knowledge of the
disease had led the Surgeons of the time to adopt it before the skin was hopelessly infiltrated, they must
have met with more success than they appear to have done. Postponing, however, all operation until the skin
was brawny and covered with tubercles, and the deeper textures were involved without limit, they failed too
often, with even such extensive cutting as they adopted, to comprehend the entire disease. It was a mistaken
kindness which led to a change of this mode of operating. Under the influence of a clergyman, who
expressed what must have been a prevailing horror at such Amazonian surgery, the practice was changed to
an incision in the integument, which was reflected in flaps and brought together again after the removal of
the cancerous tumour. There could have been no diminution of suffering by this prolongation of the
operation, and what was gained by it in neatness was lost in life."
Calendar of Events
6th World Conference on Breast Cancer, June 7 -11, 2011, Hamilton, Ontario, Canada
13th Milan Breast Cancer Conference, June 22-24, 2011, Milan Italy
1st International Michelangelo Conference, June 30 - July 1, Milan, Italy
Breast Cancer Symposium 2011, September 8-10, 2011, San Francisco, California
7th Meet the Professor. Modena International Breast Cancer Conference (MIBCC)
October 5-7, 2011, Modena, Italy
1st Advanced Breast Cancer International Consensus Conference, November 3-5, 2011, Lisbon,
Portugal
AORTIC (African Organisation for Research and Training in Cancer) - 8th International Conference,
2 di 3 01/06/2011 16:17](https://image.slidesharecdn.com/june12011-senology-orgnewsletter-110601092011-phpapp02/85/June-1-2011-Senology-org-Newsletter-2-320.jpg)
![Senology Newsletter http://www.senology.org/newsletter/Newsl_Jun2011.htm
November 28 - December 2, 2011, Cairo, Egypt
Literature Selection
Hu J et al.: "Dietary cholesterol intake and cancer", Ann Oncol. 2011 May 4. [Epub ahead of print]
Nagle CM et al.: "Reducing Time to Diagnosis Does Not Improve Outcomes for Women With
Symptomatic Ovarian Cancer: A Report From the Australian Ovarian Cancer Study Group", J Clin
Oncol. 2011 May 2. [Epub ahead of print]
Syrjala KL et al.: "Prospective Neurocognitive Function Over 5 Years After Allogeneic
Hematopoietic Cell Transplantation for Cancer Survivors Compared With Matched Controls at 5
Years", J Clin Oncol. 2011 May 2. [Epub ahead of print]
Zhu H et al.: "Thoracic radiation therapy improves the overall survival of patients with
extensive-stage small cell lung cancer with distant metastasis", Cancer. 2011 May 11. doi:
10.1002/cncr.26206. [Epub ahead of print]
Schenk JM et al.: "Association of Symptomatic Benign Prostatic Hyperplasia and Prostate Cancer:
Results from the Prostate Cancer Prevention Trial", Am J Epidemiol. 2011 May 3. [Epub ahead of
print]
Bill-Axelson A et al.: "Radical prostatectomy versus watchful waiting in early prostate cancer", N
Engl J Med. 2011 May 5;364(18):1708-17
Jacobs EJ et al.: "A Large Cohort Study of Long-term Acetaminophen Use and Prostate Cancer
Incidence", Cancer Epidemiol Biomarkers Prev. 2011 May 17. [Epub ahead of print]
Richman EL et al.: "Physical Activity after Diagnosis and Risk of Prostate Cancer Progression: Data
from the Cancer of the Prostate Strategic Urologic Research Endeavor", Cancer Res. 2011 May 24.
[Epub ahead of print]
Wilson KM et al.: "Coffee Consumption and Prostate Cancer Risk and Progression in the Health
Professionals Follow-up Study", J Natl Cancer Inst. 2011 May 17. [Epub ahead of print]
Literature Selection
Altman D et al.: "Anterior colporrhaphy versus transvaginal mesh for pelvic-organ prolapse", N Engl
J Med. 2011 May 12;364(19):1826-36
Stay informed....
Recent Advances in Clinical Medicine
Kajstura J et al.: "Evidence for human lung stem cells", N Engl J Med. 2011 May 12;364(19):1795-806
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June 1, 2011 Senology.org Newsletter
- 1. Senology Newsletter http://www.senology.org/newsletter/Newsl_Jun2011.htm Senology.org - Newsletter International Senologic and Oncologic Scientific Community "Connecting specialists worldwide" Editor-in-chief: Gian Paolo Andreoletti, MD Subscribe Unsubscribe Contact Back Issues Connecting Specialists Worldwide Join us on Facebook®, Twitter®, YouTube®, LinkedIn®, SlideShare®, Flickr® and Doctorsbook® and share informations, opinions and suggestions. Check out Senology.org Newspaperand follow our RSS feeds for real-time updates Literature Selection Li J et al.: "Coffee consumption modifies risk of estrogen-receptor negative breast cancer", Breast Cancer Res. 2011 May 14;13(3):R49. [Epub ahead of print] Elkin EB et al.: "Characteristics and Outcomes of Breast Cancer in Women With and Without a History of Radiation for Hodgkin's Lymphoma: A Multi-Institutional, Matched Cohort Study", J Clin Oncol. 2011 May 16. [Epub ahead of print] Kirsh VA et al.: "Tumor Characteristics Associated With Mammographic Detection of Breast Cancer in the Ontario Breast Screening Program", J Natl Cancer Inst. 2011 May 3. [Epub ahead of print] Ohsumi S et al.: "Detection of isolated ipsilateral regional lymph node recurrences by F18-fluorodeoxyglucose positron emission tomography-CT in follow-up of postoperative breast cancer patients" Freedman AN et al.: "Benefit/Risk Assessment for Breast Cancer Chemoprevention With Raloxifene or Tamoxifen for Women Age 50 Years or Older", J Clin Oncol. 2011 May 2. [Epub ahead of print] Hatzis C et al.: "A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer", JAMA. 2011 May 11;305(18):1873-81 Pfeiler G et al.: "Impact of Body Mass Index on the Efficacy of Endocrine Therapy in Premenopausal Patients With Breast Cancer: An Analysis of the Prospective ABCSG-12 Trial", J Clin Oncol. 2011 May 9. [Epub ahead of print] Nedumpara T et al.: "Impact of immediate breast reconstruction on breast cancer recurrence and survival", Breast. 2011 May 19. [Epub ahead of print] Petit JY et al.: "Locoregional recurrence risk after lipofilling in breast cancer patients", Ann Oncol. 2011 May 24. [Epub ahead of print] Arver B et al.: "Bilateral Prophylactic Mastectomy in Swedish Women at High Risk of Breast Cancer: A National Survey", Ann Surg. 2011 Jun;253(6):1147-1154 1 di 3 01/06/2011 16:17
- 2. Senology Newsletter http://www.senology.org/newsletter/Newsl_Jun2011.htm Ono M et al.: "Tumor-infiltrating lymphocytes are correlated with response to neoadjuvant chemotherapy in triple-negative breast cancer", Breast Cancer Res Treat. 2011 May 12. [Epub ahead of print] Comment "The 21-gene assay in early-stage breast cancer" - David B. Geffen, Department of Oncology, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev. Beer Sheva, Israel "The prognosis of early stage estrogen receptor positive breast cancer is generally very good and the average benefit of adding adjuvant chemotherapy to adjuvant endocrine therapy is small but exists. The 21-gene recurrence score (RS) assay has been validated through the use of retrospective studies as prognostic of distant disease recurrence and predictive of the benefit of adding chemotherapy. We evaluated the impact of using the test in our practice, a university based group of oncologists who have a uniform treatment policy. For a high risk RS, chemotherapy was recommended, for a low risk, endocrine therapy alone and for intermediate risk, treatment based on traditional clinicopathologic factors with help from Adjuvant!on-line. In this retrospective analysis of 135 patients whom we tested with the 21-gene RS between 2006- 2009, in 25 % of patients we changed recommendation after obtaining results. Most changes were in the direction of not giving chemotherapy (70% of changes). A somewhat surprising finding was that 29 % of the 49 patients for whom we recommended chemotherapy after obtaining the RS, refused chemotherapy. The RS substantially reduced the number of patients receiving chemotherapy but we need to improve our patients' understanding of the implications of the test" (Comment on: Geffen DB et al.: "The impact of the 21-gene recurrence score assay on decision making about adjuvant chemotherapy in early-stage estrogen-receptor-positive breast cancer in an oncology practice with a unified treatment policy", Ann Oncol. 2011 Mar 1. [Epub ahead of print]) Healthcare Companies News Genomic Health announces positive preliminary results of Oncotype DX® study in DCIS breast cancer Share your opinions and comments on LinkedIn® Fragments of History Charles H. Moore:, Royal Medical and Chirugical Society, London, 1867: “On the influence of inadequate operations on the theory of cancer", Med Chir Trans, 1867, 32: 245-80: “Taught without doubt by foregoing failures, our surgical ancestors adopted a method of operating which might well have been expected to prove effectual against a local recurrence of the disease. They transfixed the base of the mamma, and, raising it with ligatures, swept off the whole organ, together with all the skin that covered it. The proceeding had a barbarous appearance enough, but it was promising; and, if their knowledge of the disease had led the Surgeons of the time to adopt it before the skin was hopelessly infiltrated, they must have met with more success than they appear to have done. Postponing, however, all operation until the skin was brawny and covered with tubercles, and the deeper textures were involved without limit, they failed too often, with even such extensive cutting as they adopted, to comprehend the entire disease. It was a mistaken kindness which led to a change of this mode of operating. Under the influence of a clergyman, who expressed what must have been a prevailing horror at such Amazonian surgery, the practice was changed to an incision in the integument, which was reflected in flaps and brought together again after the removal of the cancerous tumour. There could have been no diminution of suffering by this prolongation of the operation, and what was gained by it in neatness was lost in life." Calendar of Events 6th World Conference on Breast Cancer, June 7 -11, 2011, Hamilton, Ontario, Canada 13th Milan Breast Cancer Conference, June 22-24, 2011, Milan Italy 1st International Michelangelo Conference, June 30 - July 1, Milan, Italy Breast Cancer Symposium 2011, September 8-10, 2011, San Francisco, California 7th Meet the Professor. Modena International Breast Cancer Conference (MIBCC) October 5-7, 2011, Modena, Italy 1st Advanced Breast Cancer International Consensus Conference, November 3-5, 2011, Lisbon, Portugal AORTIC (African Organisation for Research and Training in Cancer) - 8th International Conference, 2 di 3 01/06/2011 16:17
- 3. Senology Newsletter http://www.senology.org/newsletter/Newsl_Jun2011.htm November 28 - December 2, 2011, Cairo, Egypt Literature Selection Hu J et al.: "Dietary cholesterol intake and cancer", Ann Oncol. 2011 May 4. [Epub ahead of print] Nagle CM et al.: "Reducing Time to Diagnosis Does Not Improve Outcomes for Women With Symptomatic Ovarian Cancer: A Report From the Australian Ovarian Cancer Study Group", J Clin Oncol. 2011 May 2. [Epub ahead of print] Syrjala KL et al.: "Prospective Neurocognitive Function Over 5 Years After Allogeneic Hematopoietic Cell Transplantation for Cancer Survivors Compared With Matched Controls at 5 Years", J Clin Oncol. 2011 May 2. [Epub ahead of print] Zhu H et al.: "Thoracic radiation therapy improves the overall survival of patients with extensive-stage small cell lung cancer with distant metastasis", Cancer. 2011 May 11. doi: 10.1002/cncr.26206. [Epub ahead of print] Schenk JM et al.: "Association of Symptomatic Benign Prostatic Hyperplasia and Prostate Cancer: Results from the Prostate Cancer Prevention Trial", Am J Epidemiol. 2011 May 3. [Epub ahead of print] Bill-Axelson A et al.: "Radical prostatectomy versus watchful waiting in early prostate cancer", N Engl J Med. 2011 May 5;364(18):1708-17 Jacobs EJ et al.: "A Large Cohort Study of Long-term Acetaminophen Use and Prostate Cancer Incidence", Cancer Epidemiol Biomarkers Prev. 2011 May 17. [Epub ahead of print] Richman EL et al.: "Physical Activity after Diagnosis and Risk of Prostate Cancer Progression: Data from the Cancer of the Prostate Strategic Urologic Research Endeavor", Cancer Res. 2011 May 24. [Epub ahead of print] Wilson KM et al.: "Coffee Consumption and Prostate Cancer Risk and Progression in the Health Professionals Follow-up Study", J Natl Cancer Inst. 2011 May 17. [Epub ahead of print] Literature Selection Altman D et al.: "Anterior colporrhaphy versus transvaginal mesh for pelvic-organ prolapse", N Engl J Med. 2011 May 12;364(19):1826-36 Stay informed.... Recent Advances in Clinical Medicine Kajstura J et al.: "Evidence for human lung stem cells", N Engl J Med. 2011 May 12;364(19):1795-806 Unsubscribe www.senology.org 3 di 3 01/06/2011 16:17