This document provides guidelines and protocols for an effective closed-loop referral system in Lakes State, South Sudan. It defines key terms and outlines the requirements for an effective referral system. The referral mechanism involves community-level identification and registration of pregnant women by traditional birth attendants. At the health facility level, patients can be referred from primary health centers to county hospitals and from counties to Rumbek State Hospital. A 24-hour emergency call center is established at Rumbek State Hospital to receive referrals. The roles and responsibilities of referring and receiving facilities are defined. Standard referral forms and feedback are used to complete the referral loop. The goal is to strengthen the referral chain and improve access to services, particularly for maternal and child health.