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When should we be concerned about
      late-talking toddlers?

      Dorothy V. M. Bishop



                                    1
Wide variation in age at first words
                                         Language milestones

             100
              90
              80
              70                                                                      Boys, sentences
        Percentile




% children
              60
with words                                                                            Girls sentences
or sentences 50                                                                       Boys, single words
at given age 40
              30                                                                      Girls, single words
              20
              10                                                                  Single words-”Three or four
               0                                                                  different words for people or
                                                                                  objects, correctly used.”
                     0             12                  24                 36      Sentences-”Three or more
                                                                                  words, strung together to
                                     Age in months                                make some sort of sense.”


    Epidemiological sample of children born in Newcastle-upon-Tyne
     Neligan, G. A., & Prudham, D. (1969). Norms for four standard developmental
     milestones by sex, social class and place in family. Developmental Medicine and Child
     Neurology, 11, 413-422.                                                                              2
Most children with long-term language
     problems were late talkers
                              Language milestones

             100
              90
              80
              70
Percentile




              60                                         Boys, single words
              50                                         Girls, single words
              40
                                                         SLI
              30
              20
              10
               0
                   0   12    24      36     48      60
                            Age in months

Red shows Neligan/Prudham norms
Blue shows children from Dawn House School- NB severe SLI
                                                                               3
Only 12% of SLI had first words before 18 months
http://www.johnbercow.co.uk/
        23012007_disabled_children
• I believe that we suffer continually in this country from
  a problem of late assessment, late identification and
  late diagnosis. ….

•    I believe that sometimes those operating the system
    play precisely upon the hopes, as well as the more
    exaggerated fears, of some parents by saying, “Don’t
    worry. There’s plenty of time.” Of course, those who
    are articulating that message very often have a
    reason of financial self-interest for holding back the
    provision of what is needed.
                                                              4
Most children who have SLI were late talkers,
      ≠ most late talkers will have SLI

   Key issue of ‘base rates’

   Consider population of 1000 children
   • In whole population, 10% are late talkers = 100
     cases
   • Suppose 3% of children have severe SLI
       In population of 1000, will be 30 cases of severe
       SLI
       88% of severe SLI were late talkers (i.e. first
       words after 18 months), = 26 cases
   • So only 26/100 late talkers will have severe SLI
                                                   5
Butphenomenon ofdo ‘grow out of it’:
The  many children the ‘late bloomer’
           Late bloomers

       Fischel et al (1989)

       •26 2-year-olds who “understood complete sentences
        but who could say only a few words.”

       •Followed after 5 months
            Approx 1/3 no improvement
            1/3 mild improvement
            1/3 in the normal range

Fischel, J. E., Whitehurst, G. J., Caulfield, M. B., & Debaryshe, B. (1989). Language
growth in children with expressive language delay. Pediatrics, 83, 218-227.             6
General agreement: early
     intervention better than late


• Failure to intervene may lead to
  development of secondary problems
• Also, notion of brain plasticity
• Easier to modify brain development before
  neural pathways are committed

                                          7
Brain plasticity example:
                  eye-patching (occlusion) for ‘lazy eye’

                             Effectiveness of occlusion by age

                       100
 % change eye acuity




                                                                                In vision,
                        80
                                                                                much better
     difference




                        60                                                      outcome of
                                                                                treatment if
                        40                                                      done early in
                                                                                life
                        20

                         0
                             24   36   48   60   72   84   96 108 120 132 144
                                                 Age (months)

Epelbaum, M. et al (1993). The sensitive period for strabismic amblyopia in humans.        8
Ophthalmology, 100(3), 323-327.
Is there a “sensitive period” for language
   Evidence from ‘natural experiments’, e.g. ultimate skill of second language
   learners much better for those who came to new country before 10 yr old

        Adults tested on grammaticality judgement task, e.g. judge correct/incorrect:
                 The man allows his son to watch TV
                 The man allows his son watch TV
                 The man lets his son to watch TV
                 The man lets his son watch TV
              Grammar test score




                                   280

                                   260

                                   240

                                   220

                                   200
                                         native   3 to 7    8 to 10    11 to 15      17 to 39
                                                     Age at arriving in US

Johnson, J. S., & Newport, E. L. (1989). Critical period effects in second language learning: the influence of
maturational state on the acquisition of English as a second language. Cognitive Psychology, 21, 60-99 9 .
The quandary

• Late intervention
  – Children develop secondary problems
  – May be less effective than earlier


• Early intervention:
  – Risk of intervening with children who are just
    ‘late bloomers’ – wasted resources
  – May create problems in the child
                                                     10
What is needed

• Some way of distinguishing ‘late bloomers’
  from those with more persistent problems




                                           11
How to find out?
• Need studies that start with late talkers
  and follow them up
• At follow-up, divide into those who have
  resolved and those with persistent
  problems
• Then look at time 1 data and see if we
  could have distinguished them


                                              12
What factors likely to affect
                     outcome?

•   Home environment*
•   Birth risk*
•   Genetic risk*
•   Severity of language delay
•   Profile of language difficulties
* Predictors of late talking in study by Zubrick, S. R., et al (2007). Late language emergence at
24 months: An epidemiological study of prevalence, predictors, and covariates. Journal of
Speech, Language and Hearing Research, 50(6), 1562-1592. doi:                               13
10.1044/1092-4388(2007/106)
Our study: the children

  • Recruited from a database of families from local
    maternity ward and local toddler groups.
  • Mothers filled in Oxford University
    Communicative Development Inventory (OCDI)
    when child 18-19 mo old: long list of words –
    parent indicates if child says word and
    understands it, or just understands, or neither
Bishop, D. V. M., Holt, G., Line, E., McDonald, D., McDonald, S., & Watt, H. (2012).
Parental phonological memory contributes to prediction of outcome of late talkers from 20
months to 4 years: a longitudinal study of precursors of specific language impairment.
Journal of Neurodevelopmental Disorders, 4(3). doi: 10.1186/1866-1955-4-3                 14
Section of OCDI                understands



understands
and says




Total OCDI has 416 words; At 18 months, bottom 15% say <= 10 words
                                                                 15
The children

• 26 late talkers: expressive OCDI more than 1 SD below
  the mean (<= 10 words)
• 70 average talkers: OCDI from 20th to 75th centile
• Aimed to include children with a family history of
  speech/language problems
   – defined as having 1st degree relative with history of receiving
     intervention for language or reading problems
• Child seen for a language and cognitive assessment

• 24 late talkers and 59 average talkers available for
  follow-up at 4 yr.                                                   16
Assessment at 20 months

• Vineland Adaptive Behavior Scales, 2nd edition
  (VABS)
  – Parental interview used to evaluate the child's
    development in the areas of Communication,
    Socialisation, Daily Living, and Motor Skills.
• Mullen Scales of Early Learning
  – Child-based assessment that provides scores for
    Gross Motor, Visual Reception, Fine Motor,
    Expressive Language, and Receptive Language
    skills.

                                                      17
Assessment at 20 months

• Mullen Scales of
  Early Learning
  – Child-based
    assessment that
    provides scores
    for Gross Motor,
    Visual Reception,
    Fine Motor,
    Expressive
    Language, and
    Receptive
    Language skills.
                                18
Assessment at 4 years


• Nonverbal Ability
• Expressive and receptive language
• Parental report of communication skills

Also brief assessment of parental language (done when
  child 20 months and 4 years – just one parent, usually
  the mother)




                                                           19
Classification at 4 yrs
                                                N
•    Typical development (TD): Normal range
    nonverbal ability and no more than one
    impaired language measure                   60

• Specific language impairment (SLI): impaired
  on at least two language measures, with normal 15
  nonverbal ability

• In addition, 7 children with below average
  nonverbal ability – not considered further




                                                      20
Predicting outcome for individual children

Best prediction of 4 yr outcome from:
• Child’s language at 20 months + family history +
  parent nonword repetition;
   Prediction was better than chance, but far from
    perfect




                                                 21
Clinical prediction for individual children

Simple rules of thumb from our data:
High risk of persistent language problems if:
  + Family history and mother scores more than 1
  SD below average on nonword repetition test.
OR
  No family history but Vineland communication is
  below 85 (1 SD below mean)



                                                22
Other factors to consider

Thal et al (1991)
• Poor outcome specifically in those with poor
  comprehension/gesture
Our study
• Comprehension measures did not add much to
  prediction but our sample had few children with
  poor comprehension at 18 months
• Have not yet analysed measures of gesture
Thal, D. J., Tobias, S., & Morrison, D. (1991). Language and gesture in late talkers: a
one-year follow-up. Journal of Speech and Hearing Research, 34, 604-612.
                                                                                          23
Summary
• Majority of late talkers did not have later
  language difficulties
• Having a family history of language/literacy
  problems is a risk factor for persisting problems
• Poor comprehension or lack of gesture may also
  be important predictors
• Parental report on Vineland can also help
  identify those likely to need help
• Appropriate to adopt ‘watchful waiting’ strategy
  with late talkers who have good comprehension
  and don’t have family history of language
  problems                                          24

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Late talker ppt

  • 1. When should we be concerned about late-talking toddlers? Dorothy V. M. Bishop 1
  • 2. Wide variation in age at first words Language milestones 100 90 80 70 Boys, sentences Percentile % children 60 with words Girls sentences or sentences 50 Boys, single words at given age 40 30 Girls, single words 20 10 Single words-”Three or four 0 different words for people or objects, correctly used.” 0 12 24 36 Sentences-”Three or more words, strung together to Age in months make some sort of sense.” Epidemiological sample of children born in Newcastle-upon-Tyne Neligan, G. A., & Prudham, D. (1969). Norms for four standard developmental milestones by sex, social class and place in family. Developmental Medicine and Child Neurology, 11, 413-422. 2
  • 3. Most children with long-term language problems were late talkers Language milestones 100 90 80 70 Percentile 60 Boys, single words 50 Girls, single words 40 SLI 30 20 10 0 0 12 24 36 48 60 Age in months Red shows Neligan/Prudham norms Blue shows children from Dawn House School- NB severe SLI 3 Only 12% of SLI had first words before 18 months
  • 4. http://www.johnbercow.co.uk/ 23012007_disabled_children • I believe that we suffer continually in this country from a problem of late assessment, late identification and late diagnosis. …. • I believe that sometimes those operating the system play precisely upon the hopes, as well as the more exaggerated fears, of some parents by saying, “Don’t worry. There’s plenty of time.” Of course, those who are articulating that message very often have a reason of financial self-interest for holding back the provision of what is needed. 4
  • 5. Most children who have SLI were late talkers, ≠ most late talkers will have SLI Key issue of ‘base rates’ Consider population of 1000 children • In whole population, 10% are late talkers = 100 cases • Suppose 3% of children have severe SLI In population of 1000, will be 30 cases of severe SLI 88% of severe SLI were late talkers (i.e. first words after 18 months), = 26 cases • So only 26/100 late talkers will have severe SLI 5
  • 6. Butphenomenon ofdo ‘grow out of it’: The many children the ‘late bloomer’ Late bloomers Fischel et al (1989) •26 2-year-olds who “understood complete sentences but who could say only a few words.” •Followed after 5 months Approx 1/3 no improvement 1/3 mild improvement 1/3 in the normal range Fischel, J. E., Whitehurst, G. J., Caulfield, M. B., & Debaryshe, B. (1989). Language growth in children with expressive language delay. Pediatrics, 83, 218-227. 6
  • 7. General agreement: early intervention better than late • Failure to intervene may lead to development of secondary problems • Also, notion of brain plasticity • Easier to modify brain development before neural pathways are committed 7
  • 8. Brain plasticity example: eye-patching (occlusion) for ‘lazy eye’ Effectiveness of occlusion by age 100 % change eye acuity In vision, 80 much better difference 60 outcome of treatment if 40 done early in life 20 0 24 36 48 60 72 84 96 108 120 132 144 Age (months) Epelbaum, M. et al (1993). The sensitive period for strabismic amblyopia in humans. 8 Ophthalmology, 100(3), 323-327.
  • 9. Is there a “sensitive period” for language Evidence from ‘natural experiments’, e.g. ultimate skill of second language learners much better for those who came to new country before 10 yr old Adults tested on grammaticality judgement task, e.g. judge correct/incorrect: The man allows his son to watch TV The man allows his son watch TV The man lets his son to watch TV The man lets his son watch TV Grammar test score 280 260 240 220 200 native 3 to 7 8 to 10 11 to 15 17 to 39 Age at arriving in US Johnson, J. S., & Newport, E. L. (1989). Critical period effects in second language learning: the influence of maturational state on the acquisition of English as a second language. Cognitive Psychology, 21, 60-99 9 .
  • 10. The quandary • Late intervention – Children develop secondary problems – May be less effective than earlier • Early intervention: – Risk of intervening with children who are just ‘late bloomers’ – wasted resources – May create problems in the child 10
  • 11. What is needed • Some way of distinguishing ‘late bloomers’ from those with more persistent problems 11
  • 12. How to find out? • Need studies that start with late talkers and follow them up • At follow-up, divide into those who have resolved and those with persistent problems • Then look at time 1 data and see if we could have distinguished them 12
  • 13. What factors likely to affect outcome? • Home environment* • Birth risk* • Genetic risk* • Severity of language delay • Profile of language difficulties * Predictors of late talking in study by Zubrick, S. R., et al (2007). Late language emergence at 24 months: An epidemiological study of prevalence, predictors, and covariates. Journal of Speech, Language and Hearing Research, 50(6), 1562-1592. doi: 13 10.1044/1092-4388(2007/106)
  • 14. Our study: the children • Recruited from a database of families from local maternity ward and local toddler groups. • Mothers filled in Oxford University Communicative Development Inventory (OCDI) when child 18-19 mo old: long list of words – parent indicates if child says word and understands it, or just understands, or neither Bishop, D. V. M., Holt, G., Line, E., McDonald, D., McDonald, S., & Watt, H. (2012). Parental phonological memory contributes to prediction of outcome of late talkers from 20 months to 4 years: a longitudinal study of precursors of specific language impairment. Journal of Neurodevelopmental Disorders, 4(3). doi: 10.1186/1866-1955-4-3 14
  • 15. Section of OCDI understands understands and says Total OCDI has 416 words; At 18 months, bottom 15% say <= 10 words 15
  • 16. The children • 26 late talkers: expressive OCDI more than 1 SD below the mean (<= 10 words) • 70 average talkers: OCDI from 20th to 75th centile • Aimed to include children with a family history of speech/language problems – defined as having 1st degree relative with history of receiving intervention for language or reading problems • Child seen for a language and cognitive assessment • 24 late talkers and 59 average talkers available for follow-up at 4 yr. 16
  • 17. Assessment at 20 months • Vineland Adaptive Behavior Scales, 2nd edition (VABS) – Parental interview used to evaluate the child's development in the areas of Communication, Socialisation, Daily Living, and Motor Skills. • Mullen Scales of Early Learning – Child-based assessment that provides scores for Gross Motor, Visual Reception, Fine Motor, Expressive Language, and Receptive Language skills. 17
  • 18. Assessment at 20 months • Mullen Scales of Early Learning – Child-based assessment that provides scores for Gross Motor, Visual Reception, Fine Motor, Expressive Language, and Receptive Language skills. 18
  • 19. Assessment at 4 years • Nonverbal Ability • Expressive and receptive language • Parental report of communication skills Also brief assessment of parental language (done when child 20 months and 4 years – just one parent, usually the mother) 19
  • 20. Classification at 4 yrs N • Typical development (TD): Normal range nonverbal ability and no more than one impaired language measure 60 • Specific language impairment (SLI): impaired on at least two language measures, with normal 15 nonverbal ability • In addition, 7 children with below average nonverbal ability – not considered further 20
  • 21. Predicting outcome for individual children Best prediction of 4 yr outcome from: • Child’s language at 20 months + family history + parent nonword repetition; Prediction was better than chance, but far from perfect 21
  • 22. Clinical prediction for individual children Simple rules of thumb from our data: High risk of persistent language problems if: + Family history and mother scores more than 1 SD below average on nonword repetition test. OR No family history but Vineland communication is below 85 (1 SD below mean) 22
  • 23. Other factors to consider Thal et al (1991) • Poor outcome specifically in those with poor comprehension/gesture Our study • Comprehension measures did not add much to prediction but our sample had few children with poor comprehension at 18 months • Have not yet analysed measures of gesture Thal, D. J., Tobias, S., & Morrison, D. (1991). Language and gesture in late talkers: a one-year follow-up. Journal of Speech and Hearing Research, 34, 604-612. 23
  • 24. Summary • Majority of late talkers did not have later language difficulties • Having a family history of language/literacy problems is a risk factor for persisting problems • Poor comprehension or lack of gesture may also be important predictors • Parental report on Vineland can also help identify those likely to need help • Appropriate to adopt ‘watchful waiting’ strategy with late talkers who have good comprehension and don’t have family history of language problems 24