Link in june 2010
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The document discusses depression and aims to find new treatments. It hypothesizes that the human brain mineralocorticoid receptor (MR), which binds cortisol, is crucial for behavior during stress and the hormonal stress response. Dysfunction of the MR may lead to vulnerability for depression and anxiety, so the researchers propose the MR as a new drug target for treating depression and anxiety disorders.
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Link in june 2010
- 1. Depression: Loss of interest Lack of pleasure Many other features Treatment efficacy has to improve Little known about biological background Aim: to find new treatments for depression
- 2. Biochemical mechanisms in psychopathology Stress Precipitates psychopathologies CRH cortisol
- 3. MR - GR Cortisol ACTH CRH Brain Mineralocorticoid Receptor (MR) Cortisol MR Aldosterone Perception Reaction Learning Consolidation
- 4. We aim to show that the human brain mineralocorticoid receptor (MR) (which binds cortisol in the brain) is a crucial factor in: Behavior during stress The hormonal stress-response (cortisol) We hypothesize that dysfunction of the MR will lead to vulnerability for depression and anxiety. We also propose the MR as a new drug target for depression and anxiety disorders.