Lombardi comprehensive cancer center Georgetown
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This document provides an overview of the Lombardi Comprehensive Cancer Center and the role of informatics. It describes that Lombardi was established in 1970 and became an NCI-designated cancer center in 1974. It conducts over $100M in research annually across 4 research programs and 9 shared resources. Key accomplishments include developing the HPV vaccine and discoveries in DNA repair and breast cancer. The Innovation Center for Biomedical Informatics (ICBI) supports Lombardi through expertise in various informatics areas including data management, software development, and clinical genomics. ICBI has various resources and linkages to data across Lombardi to support discovery, clinical research, and education.
Lombardi comprehensive cancer center Georgetown
- 1. Lombardi Comprehensive Cancer Center Cancer Informatics Summit 2/21/2013 Subha Madhavan, Ph.D. Director, Innovation Center for Biomedical Informatics Georgetown University Medical Center Director, Clinical Research Informatics Lombardi Comprehensive Cancer Center
- 2. Vincent T. Lombardi • Famous professional football coach • Fell ill at Washington Redskins’ practice on Georgetown University field • Treated for cancer at Georgetown “Winning isn’t everything, it’s the only thing.” • Cancer Center named in his honor
- 3. Lombardi – At a glance • Established in 1970 • In 1974, Georgetown Lombardi became the 16th NCI-designated Comprehensive Cancer Center • Over $100M in research funding ever year – $35M CCSG + peer-reviewed funding base • 94 full members; 186 cancer-connected faculty members • 4 Research programs & 9 Shared resources • 220 ongoing trials
- 4. Key Accomplishments • Development of human papillomavirus (HPV) vaccine to prevent cervical cancer – R. Schlegel • Discovery of GADD-4 DNA repair gene – A. Fornace • Nuclear hormone receptor networks in breast cancer – R. Clarke • Monoclonal antibody therapy – L. Weiner
- 5. General Organizational Structure Director (Weiner) Deputy Director (Atkins) Clinical Care (Marshall) Clinical Research (Giaccone) Population Sciences (Mandelblatt) Basic Research (Wellstein) Minority Health (Campbell) Shared Resources (Byers) Administration (VanderHoek)
- 6. Another view of the cancer center IAC EAC Director Deputy Dir Community Advisory Council AD Basic/Transl Network Representative Administration Research Education MO CPC BC ET Trial Oversight AD Clinical Shared Resources AD Administration AD Minority Health AD Population AD Shared Resources
- 8. Innovation Center for Biomedical Informatics (ICBI) http://icbi.georgetown.edu/ • • • • • • Faculty – 5 Senior staff members – 5 Research associates – 5 Support staff – 2 Consultants – 5 Students/Trainees - 2 Expertise in bioinformatics, clinical informatics, biomathematics, biostatistics, clinical genomics, molecular biology, high-throughput molecular assays, enterprise class software development, data management, data security, & project management
- 9. Informatics Org Chart Cancer Center Director CCSG SR Director CTSA PI Dean of Research ICBI Director Director, Operations Office Manager Highthroughput omics Financial Analyst Communications/ Scientific writing Technology Development Health IT ChemiInformatics Data Coordination & Biocuration FTEs supporting Cancer Center – 8 Total FTEs - 22 Clinical Research Informatics
- 10. Informatics Funding $3.5M Total Annual Funding in 2012
- 11. Lombardi Information Architecture (current & future)
- 12. Integrated Data Environment: G-DOC Links to Many of Data Silos Pathway Studio Cytoscape • Systems biology • Literature •Visualization networks JMol/Marvin Ingenuity Analysis • Molecule Visualization •Pathways, GO, Variants G-DOC RedCap Clinical Research JBrowse •Genome Visualization Disease Classification Tools EHR’s
- 13. https://gdoc.georgetown.edu Over 330 registered users from six countries ~250 unique hits/month
- 14. Making Patients Part of Healthcare Through Technology Innovations
- 15. Next Generation Sequencing Big Data Analytics on the Cloud Genomic Data De-identified Clinical data PC User Genome Data Amazon S3 Bucket Amazon EC2 Compute Instances G-DOC Web Portal Clinical Data Amazon Glacier Vault MongoDB EC2 Instances Oracle RDS Instance
- 16. Informatics for Discovery, Clinical Research, Clinical Care • ‘omics’ data analysis Clinical Research Clinical Education • EHR/PHR integration • Informatics education • Biomarker discovery • Partnerships • Disease classification • Joint grants • Genotype-Phenotype correlation • Contracted services • Biospecimen management and analysis • Medical internships • Joint appointments • Shared resources • Shared IP • Technology/method development • Joint publications Basic/Traslational Biospecimen Website : https://icbi.georgetown.edu Email : icbi@georgetown.edu
- 17. Challenges & Opportunities Major Challenges: Diverse set of policies and regulations across participating institutions Lack of resources (human and IT) Multiple clinical & research information silo’es Significant Opportunities/Strengths: Technology development Community engagement Test bed for innovation ‘omics’ methods & integration Collaborations with CTSA