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2D Echo Lecture
Series:
M Mode
Ceres P. Canto MD
Objectives
To discuss M Mode Ultrasound
Physics
To enumerate the strengths and
limitations of M Mode ultrasound
To discuss the normal and
pathologic M mode findings
To discuss the other clinical
applications of M mode
Overview
History
Ultrasound Physics
Clinical Use and Limitations
Normal and Pathologic M
Mode Findings
Additional Applications
Left
Ventricle
Mitral Valve Aortic Valve
Pulmonic
Valve
Tricuspid
Valve
Pericardium
IVC
History
• Motion or “M” mode echocardiography is
among the earliest forms of cardiac
ultrasound
• Dr. Inge Edler and physicist Hellmuth Hertz
developed ultrasound for clinical use
• The original description of M-mode
echocardiography in 1953 marked the
beginning of a new noninvasive diagnostic
technique
• initially used primarily for the preoperative
study of mitral valve stenosis
• “ice pick view of the heart”
3 basic
modes to
image the
heart
Echo Diagnosis
Doppler
imaging
M mode
imaging
2D
imaging
M mode
imaging
Ultrasound
Physics
Resolution
• Ability to distinguish two points in space
• 2 Components:
1) Spatial
- Smallest distance that two targets can be
separated for the system to distinguish between
them
- 2 Components: Axial vs Lateral
2) Temporal
Spatial Resolution: Axial Resolution
• The minimum separation
between structures the
ultrasound beam can
distinguish parallel to its path
• Determinants
• Wavelength – the smaller the
better
• Pulse length – the shorter the
train of cycles the greater the
resolution
Spatial Resolution: Lateral Resolution
• Minimum separation between
structures the ultrasound
beam can distinguish in a
plane perpendicular to its
path
• Determinants
• Depends on beam width: the
smaller the better
• Depth
• Gain
Temporal Resolution
• Ability of system to accurately track
moving targets over time
• Anything that requires more time will
decrease temporal resolution
• Determinants
• Depth
• Sweep Angle
• Line Density
• Pulse repetition frequency (Herz)
The reflected signal can be displayed in
four modes
• A mode
• B mode
• M mode
• 2 Dimensional
Physics
A-mode
• the presence of a “structure” on the ultrasound
beam's path is represented on the screen by a
positive deflection (spike)
• the strength of the returning signal is
represented by its height (amplitude)
B mode
• In intensity modulated display
• B = brightness
• the signals are converted from spikes to dots
• The taller the spikes (the greater the amplitude
of the signal), the brighter the dots
• This forms the basis of M-mode as well as 2D
imaging
2D imaging
2D imaging
• Image is generated from data
obtained mechanically (mechanical
transducer) or electronically
(phased array transducer)
• The signal received undergoes a
complex manipulation to form the
final image displayed on the
monitor
• signal amplification, time-gain
compensation, filtering,
compression and rectification
M mode
• Timed Motion display
• B-mode with time reference
• A diagram that shows how the
positions of the structure change
during the course of the cardiac cycle
• Ordinate (y): Strength of the
returning echoes demonstrated by
brightness of the image
• Abscissa (x): temporal variation /
time elapsed
M mode
• The high sampling frequency
• >90% of the cycle time spent in "receive"
mode
• pulse transmission at a rate >1000/second
• Excellent temporal resolution
• Superior axial resolution
Overview
History
Ultrasound Physics
Clinical Use and Limitations
Normal and Pathologic M
Mode Findings
Additional Applications
Left
Ventricle
Mitral Valve Aortic Valve
Pulmonic
Valve
Tricuspid
Valve
Pericardium
IVC
Clinical Use and Limitations
Clinical Use
High temporal resolution:
• most useful in delineating the
path of structures moving at a
high velocity
• Useful for precise timing of
events within the cardiac cycle
• subtle changes are more readily
appreciated with m-mode than
with two-dimensional or three-
dimensional methods
Clinical Use
High axial resolution:
• allows the resolution of delicate
cardiac structures (e.g. valve
leaflets) which are difficult to
resolve, especially with
transthoracic echocardiography
Clinical
Use
may include more precise measurement of cardiac
chambers (provided they are obtained on-axis)
independent motion of valvular vegetations
early closure or early opening of valve structures
with respect to timing in the cardiac cycle
identification of prosthetic valves and their function
assessment of paradoxical interventricular septal
motion and dyssynchrony of the left ventricle
fluttering of valve leaflets seen in association with
valvular regurgitation
The exaggerated motion, as well as restricted
motion, of various cardiac structures
Limitations
having to draw conclusions in one dimension
about a three-dimensional structure
measurements are dependent on the identification
of clearly defined borders, which may not be
obtainable in technically challenging patients
If the measurements are not well standardized, M-
mode measurements can be highly variable
With respect to m-mode’s derived ejection
fractions, calculations may not be accurate when
regional wall motion abnormalities are present
Normal and
Pathologic M Mode
Findings
Overview
History
Ultrasound Physics
Clinical Use and Limitations
Normal and Pathologic M
Mode Findings
Additional Applications
Left
Ventricle
Mitral Valve Aortic Valve
Pulmonic
Valve
Tricuspid
Valve
Pericardium
IVC
Left
Ventricle
Normal M-Mode Examination of the
Left Ventricle
Moss & Adams 9th ed
• Pediatric ASE guidelines recommend use of the parasternal short-axis
views to obtain LV measurements
• If the measurements are not well standardized, M-mode measurements
can be highly variable
• Pediatric ASE recommendations suggested using measurements obtained
from two-dimensional (2-D) imaging in place of M-mode for LV chamber
quantification
• Downside:
• lower temporal resolution especially in patients with high heart rates
• normal published Z scores based on M mode measurements
Normal M-Mode Examination of the
Left Ventricle
Moss & Adams 9th ed
• Recent data from the Pediatric Heart Network indicated that the LV
dimensions could be measured with high reproducibility by both methods
and that agreement was high between the two methods (M-Mode vs. 2-D)
• For calculation of shortening fraction (SF) using M-mode was shown to
be more reproducible and it was shown that measurements differed
between both techniques
Normal M-Mode Examination of the Left
Ventricle
• Maximum short-axis dimension
• Young patients: level of the MV leaflet tips
or chordae
• Older patients and adults: more apically at
the level of the papillary muscles
• Linear measurements characterize LV
size only in one dimension
• may misrepresent an abnormally
shaped chamber
• Short-axis diameters should be
considered a surrogate for LV size only
when the LV short-axis geometry is
circular, a condition often not met in
patients with CHD or other abnormal
hemodynamic states
Normal M-Mode Examination of the Left
Ventricle
• left ventricular dimensions:
measured at end-diastole and
end-systole
• left ventricular wall thicknesses
(IVS and PW) : measured at end
diastole
• end-diastole: defined as the
frame at which the MV closes
• end-systole: the frame preceding
MV opening
Normal M-Mode Examination of the Left
Ventricle
• For the accurate measurements of
cardiac chambers, leading-edge to
leading-edge technique should be
used
• The values should be indexed to the
body surface area (BSA) and then
expressed as Z scores
NEW ASE RECOMMENDATION
Current guidelines for
chamber, annular, and
vessel quantification
involve measurements of
intraluminal dimensions
from one inner edge to the
opposite inner edge
M mode lecture
M mode lecture
M mode lecture
M mode lecture
M mode lecture
Hypertrophic
Cardiomyopathy
Approach to Echo diagnosis of HCM Use of M Mode
Confirm LV hypertrophy Septal hypertrophy
Assessment of LVOT obstruction Detect mid-systolic (premature) closure
of the aortic valve due to outflow track
obstruction
Systolic Anterior Motion (SAM) Seen on Mmode
Assessement of systolic and diastolic
LV function and LA size
LVEF and FS
M mode lecture
• Contractile dysfunction
• Ventricular dilatation
• Thin myocardial wall
• Dyssynchrony
Normal Dilated Cardiomyopathy
Dilated Cardiomyopathy:
septal-to-posterior wall
motion delay (SPWMD)
• PSAX view at the level of the
papillary muscles
• time interval between peak systolic
inward contraction of the septum
and posterior wall
• SPWMD of ≥130 ms predicted a
response to CRT
• Subsequent analyses have, however,
demonstrated limited predictive value
Bleeker et al. 2007. Am J Cardiol,
Paradoxical Septal Wall Motion
movement of the interventricular septum away from the left
ventricular free wall during systole
opposite of its normal movement which is inward toward the left
ventricle / or the left ventricular free wall during systole
Paradoxical Septal Wall Motion
Causes
• Atrial septal defect
• Constrictive pericarditis
• Post heart surgery
• LBBB
• Mitral stenosis
• Pericardial effusion (large)
• Pulmonary hypertension
• Repaired Tetralogy of Fallot
• Right ventricular hypertrophy
• Right ventricular pacing,
particularly from the right
ventricular outflow tract due to
contraction of the RV before
the LV
• Right ventricular tumor
• Right ventricular volume
overload
Overview
History
Ultrasound Physics
Clinical Use and Limitations
Normal and Pathologic M
Mode Findings
Additional Applications
Left
Ventricle
Mitral Valve Aortic Valve
Pulmonic
Valve
Tricuspid
Valve
Pericardium
IVC
Left
Ventricle
Mitral Valve
Normal M-Mode
Examination of the Mitral
Valve
• obtained from the parasternal
long-axis imaging plane
• The m-mode cursor is placed
perpendicular to the long axis of
the left ventricle at the level of the
tips of the mitral leaflet
• The anterior leaflet and posterior
leaflet are noted to open fully in
diastole and close completely
during systole
Normal M-Mode Examination
of the Mitral Valve
Mitral Stenosis
• Decreased EF slope
• Paradoxical anterior diastolic motion of
the PMVL
• Separation between leaflets is
decreased
• Leaflet tips bright and thickened
• Early diastolic dip of IVS
• Reduced MV leaflet excursion
M mode lecture
Mitral Valve Prolapse
• Thick redundant mitral valve leaflets
• Mid to late systolic / holosystolic sagging back of the
anterior, posterior or both MV from C-D point of MV
Mitral Valve Prolapse
Mitral
Valve
Prolapse
Systolic bowing of the posterior mitral valve leaflet
Flail MV leaflet
• This may occur as a result of
chordal rupture (due to
degeneration) or to papillary
muscle dysfunction
• The posterior leaflet shows
erratic movement, rather than
the normal ‘W’ pattern
• Coarse diastolic fluttering of
mitral leaflets
Flail MV leaflet
• Flail mitral leaflet may appear
within LA during systole
Infective endocarditis
• Valve leaflet appear thickened, “smudged”, “shaggy”
• Vegetation on a valve leaflet usually doesn’t restrict valve motion
M mode lecture
LA Myxoma
• Bright hyperdensity in mitral orifice
• Echo free space at anterior mitral
leaflet at onset of diastole prior
to dense echoes from tumor
• Functional MS
• Blunted E point of the mitral valve
• Decrease E-F slope
M mode lecture
Hypetrophic Cardiomyopathy
• In diastole, the mitral valve may be normal
• In systole the entire MV apparatus moves anteriorly producing a
characteristic bulge touching the interventricular septum
• systolic anterior motion (SAM) of the MV
M mode lecture
B-bump
• The B bump on mitral valve is
predictive of significant elevation
of LVEDP
• Marker of LV dysfunction
• Mitral B bump is essentially a late
diastolic phenomenon in which the
leaflets keep a semi-open position
without LV inflow effectiveness
• The resultant LA pressure work over
mitral leaflets, pushing them toward
LV generating the bump
Araujo et al. 2004. Int J Cardiol. 95(1):7-12
M mode lecture
E-point septal separation
(EPSS)
• the distance between the
anterior mitral valve leaflet and
the interventricular septum in
early diastole
• an EPSS >7 mm is 100%
sensitive for a severely
depressed ejection fraction (EF
<30%)
• as derived from comparison with
MRI, EPSS roughly equates
ejection fraction
McKaigney et al. 2014. The American journal of
emergency medicine. 32 (6): 493-7
Overview
History
Ultrasound Physics
Clinical Use and Limitations
Normal and Pathologic M
Mode Findings
Additional Applications
Left
Ventricle
Mitral Valve Aortic Valve
Pulmonic
Valve
Tricuspid
Valve
Pericardium
IVC
Left
Ventricle
Mitral Valve Aortic Valve
Normal M-Mode Examination of the
Aortic Root, Aortic Cusp Separation,
and Left Atrial Dimension
• Traditionally, m-mode measurements have
been used to quantify aortic root size, aortic
valve cusp separation, and left atrial
dimensions
• These measurements are obtained from the
parasternal long-axis imaging plane
• m-mode measurements are made leading edge
to leading edge
• The m-mode cursor is placed perpendicular to
the structure being measured
Normal M-Mode Examination of the
Aortic Root, Aortic Cusp Separation,
and Left Atrial Dimension
• Aortic root: measured in end-diastole,
just before the onset of the QRS complex
• Aortic valve cusp separation
• measured in midsystole
• The normal appearance of the aortic
cusps during systole is that of an “open
box,” which reflects holosystolic
opening of the valve leaflets
• Left atrium : measured during ventricular
systole or atrial diastole, when the left
atrium is maximally filled with blood
Aortic Valve
• The aortic valve has 3 cusps–right coronary, left
coronary and non-coronary cusps
• The cusps imaged in the PLAX view are the
right coronary and the non-coronary cusps
• Leaflet may show fine systolic fluttering in
healthy individuals
Bicuspid Aortic Valve
• M-mode echocardiography can often
be useful in helping establish the
diagnosis of a bicuspid aortic valve
• The classic appearance: eccentric
closing of the valve leaflets
• strongly suggestive of a bicuspid
aortic valve, although in some
cases, bicuspid aortic valves may
open symmetrically
M mode lecture
Aortic Stenosis
• Thickened, calcified leaflets
• Dense, persistent echoes
replacing the normal motion
patterns
• Post-stenotic aortic root
dilation
• LVH
• Eccentrically placed diastolic
closure line (BAV)
Aortic Regurgitation
• Diastolic fluttering of AMVL due
to AI jet turbulence
• Diastolic fluttering of aortic valve
• Premature closure of mitral valve
• Premature opening of aortic valve
• Dilated LV
• Increased duration between E
and A peaks
M mode lecture
M mode lecture
Overview
History
Ultrasound Physics
Clinical Use and Limitations
Normal and Pathologic M
Mode Findings
Additional Applications
Left
Ventricle
Mitral Valve Aortic Valve
Pulmonic
Valve
Tricuspid
Valve
Pericardium
IVC
Left
Ventricle
Mitral Valve Aortic Valve
Pulmonic
Valve
Normal M-Mode
Examination of the
Pulmonic Valve
• The normal m-mode recording of the
pulmonic valve is usually obtained from
the parasternal short-axis view
• can also be obtained from the right
ventricular outflow tract view and main
pulmonary artery and bifurcation view
Normal M-Mode Examination of the Pulmonic
Valve
• Like the normal aortic valve,
the normal pulmonic valve
opens throughout systole
and has the appearance of
“an open box”
Letter designation
• a = atrial contraction
• b = onset of ventricular systole
• c = ventricular ejection
• d = during ventricular ejection
• e = end of ventricular ejection
Pulmonary Hypertension
• loss of A-dip of pulmonary valve
• Flying W sign
M mode lecture
Pulmonary
Stenosis
• increase depth of
pulmonary valve
“a” wave
(increased a-dip)
Overview
History
Ultrasound Physics
Clinical Use and Limitations
Normal and Pathologic M
Mode Findings
Additional Applications
Left
Ventricle
Mitral Valve Aortic Valve
Pulmonic
Valve
Tricuspid
Valve
Pericardium
IVC
Left
Ventricle
Mitral Valve Aortic Valve
Pulmonic
Valve
Tricuspid
Valve
Normal M-Mode Examination of
the Tricuspid Valve
• The normal m-mode recording of
the tricuspid valve is obtained from
the right ventricular inflow view
• Usually, only the anterior leaflet of
the tricuspid valve is transected by
the m-mode cursor
M-mode letter designations for the tricuspid valve are as follows: D = onset of diastole, E = maximal
opening of the leaflet, F = most posterior position of the leaflet, E–F slope = closing motion of the
leaflet, A = leaflet reopening with atrial contraction, and C = leaflet closure following ventricular
systole.
M mode findings in
Tricuspid Stenosis
• Thickened TV leaflets
• Decreased EF slope of the Anterior TV
leaflet
• Anterior motion of the Posterior TV
leaflet
• Decreased/absent A wave of the
Anterior TV leaflet
• Steep A-C slope of the TV
• Pulmonary HPN due to coexisting MV
disease
Ebsteins Anomaly
• Paradoxical septal motion
• Dilated RV
• Delayed closure of the TV
leaflets >65 ms after MV
closure
• Increased velocity and
amplitude of Anterior TV
leaflet motion
Ebsteins Anomaly
• Paradoxical septal motion
• Dilated RV
• Delayed closure of the TV
leaflets >65 ms after MV
closure
• Increased velocity and
amplitude of Anterior tV
leaflet motion
M mode in
Pericardial
Diseases
Overview
History
Ultrasound Physics
Clinical Use and Limitations
Normal and Pathologic M
Mode Findings
Additional Applications
Left
Ventricle
Mitral Valve Aortic Valve
Pulmonic
Valve
Tricuspid
Valve
Pericardium
IVC
Left
Ventricle
Mitral Valve Aortic Valve
Pulmonic
Valve
Tricuspid
Valve
Pericardium
M mode lecture
Cardiac
Tamponade
•Compressed RV
•Ventricular interdependence:
increase in RV dimension with
inspiration and simultaneously
decrease in LV dimension during
inspiration
•Mitral valve:
•Decrease EF slope with
inspiration
•Decrease DE amplitude with
inspiration
•RV diastolic collapse (specific)
•RA diastolic collapse (sensitive)
•Dilated IVC with blunted respiratory
changes
Cardiac Tamponade: RA diastolic
collapse
collapse lasting more than 1/3 of systole is almost 100% sensitive and
specific for tamponade
Cardiac Tamponade: RV Diastolic
Collapse
M mode lecture
M mode lecture
M mode lecture
Cardiac Tamponade
• The increased pericardial pressure limits the ability of the right
ventricular free wall to expand and accommodate the inflow of
blood during inspiration
• The result is increased bowing of the ventricular septum into the
left ventricle as blood fills the right heart, resulting in a lower left
ventricular end diastolic volume, a lower stroke volume and
resulting lower systolic pressure.
• In more simple terms, in a non-compliant pericardial space, for
the right heart to fill more in inspiration, the left heart must fill
less
Cardiac Tamponade: ventricular
interdependence
INSPIRATION
RV size
increases
LV size
decreases
M mode lecture
M mode lecture
M mode lecture
Constrictive
pericarditis
• Pericardial thickening
• Paradoxical septal motion
• Septal bounce ( abrupt displacement of the
IVS during early diastole)
• Flattening of mid & late diastolic motion of the
posterior LV wall
• Rapid early diastolic, or E-F slope of the mitral
valve
• Rapid downward motion of the posterior aortic
wall in early diastole
• Premature opening of pulmonary valve
• Dilated IVC with blunted respiratory changes
Ventricular interdependence in
constrictive pericarditis
• the normal drop in filling
pressures will be blunted
by the thick pericardium 
prevent normal decrease in
pressure from reaching the
ventricles
• Net effect is decreased
gradient for LV filling
• The opposite occurs during
expiration.
extrapericardial intrapericardial
Septal bounce
• sign of ventricular interdependence
• ventricles are constricted (tethered by the pericardium)  motion of the ventricular
walls is markedly reduced and the volume of the heart is fixed
• Changes in ventricular volumes and pressures are then reflected through
deviations of the septum
Septal Bounce
M mode lecture
M mode lecture
inferior vena cava plethora (maximum diameter ≥21 mm and degree of
inspiratory collapse <50%
Overview
History
Ultrasound Physics
Clinical Use and Limitations
Normal and Pathologic M
Mode Findings
Additional Applications
Left
Ventricle
Mitral Valve Aortic Valve
Pulmonic
Valve
Tricuspid
Valve
Pericardium
IVC
Left
Ventricle
Mitral Valve Aortic Valve
Pulmonic
Valve
Tricuspid
Valve
Pericardium
IVC
Inferior
Vena
Cava
Other Applications
of M Mode
M mode lecture
Tricuspid annular plane systolic
excursion (TAPSE)
• Measured in the apical four-
chamber view
• systolic longitudinal
displacement of the lateral
tricuspid annulus toward the
apex
Mitral annular plane systolic
excursion (MAPSE)
• Tapse
• mapse
Color
doppler
m-mode
imaging Used to determine velocity of
propagation (Vp) of LV inflow
Determination of width of AR
jet
Duration of MR
AR jet width
Duration of mitral regurgitation
M mode lecture
M mode lecture
• The left ventricular (LV) flow velocity propagation measured by
colour M-mode Doppler (Vp) is a useful function diastolic index,
with some advantages over pulsed Doppler
• It might be used to differentiate a normal from a pseudonormal
LV filling pattern
Thank you
M mode lecture
M mode lecture
Circ Cardiovasc Imaging.
2014;7:526-534.
M mode lecture

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OPIOID ANALGESICS AND THEIR IMPLICATIONS
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M mode lecture

  • 1. 2D Echo Lecture Series: M Mode Ceres P. Canto MD
  • 2. Objectives To discuss M Mode Ultrasound Physics To enumerate the strengths and limitations of M Mode ultrasound To discuss the normal and pathologic M mode findings To discuss the other clinical applications of M mode
  • 3. Overview History Ultrasound Physics Clinical Use and Limitations Normal and Pathologic M Mode Findings Additional Applications Left Ventricle Mitral Valve Aortic Valve Pulmonic Valve Tricuspid Valve Pericardium IVC
  • 4. History • Motion or “M” mode echocardiography is among the earliest forms of cardiac ultrasound • Dr. Inge Edler and physicist Hellmuth Hertz developed ultrasound for clinical use • The original description of M-mode echocardiography in 1953 marked the beginning of a new noninvasive diagnostic technique • initially used primarily for the preoperative study of mitral valve stenosis • “ice pick view of the heart”
  • 5. 3 basic modes to image the heart Echo Diagnosis Doppler imaging M mode imaging 2D imaging M mode imaging
  • 7. Resolution • Ability to distinguish two points in space • 2 Components: 1) Spatial - Smallest distance that two targets can be separated for the system to distinguish between them - 2 Components: Axial vs Lateral 2) Temporal
  • 8. Spatial Resolution: Axial Resolution • The minimum separation between structures the ultrasound beam can distinguish parallel to its path • Determinants • Wavelength – the smaller the better • Pulse length – the shorter the train of cycles the greater the resolution
  • 9. Spatial Resolution: Lateral Resolution • Minimum separation between structures the ultrasound beam can distinguish in a plane perpendicular to its path • Determinants • Depends on beam width: the smaller the better • Depth • Gain
  • 10. Temporal Resolution • Ability of system to accurately track moving targets over time • Anything that requires more time will decrease temporal resolution • Determinants • Depth • Sweep Angle • Line Density • Pulse repetition frequency (Herz)
  • 11. The reflected signal can be displayed in four modes • A mode • B mode • M mode • 2 Dimensional
  • 12. Physics A-mode • the presence of a “structure” on the ultrasound beam's path is represented on the screen by a positive deflection (spike) • the strength of the returning signal is represented by its height (amplitude) B mode • In intensity modulated display • B = brightness • the signals are converted from spikes to dots • The taller the spikes (the greater the amplitude of the signal), the brighter the dots • This forms the basis of M-mode as well as 2D imaging
  • 13. 2D imaging 2D imaging • Image is generated from data obtained mechanically (mechanical transducer) or electronically (phased array transducer) • The signal received undergoes a complex manipulation to form the final image displayed on the monitor • signal amplification, time-gain compensation, filtering, compression and rectification
  • 14. M mode • Timed Motion display • B-mode with time reference • A diagram that shows how the positions of the structure change during the course of the cardiac cycle • Ordinate (y): Strength of the returning echoes demonstrated by brightness of the image • Abscissa (x): temporal variation / time elapsed
  • 15. M mode • The high sampling frequency • >90% of the cycle time spent in "receive" mode • pulse transmission at a rate >1000/second • Excellent temporal resolution • Superior axial resolution
  • 16. Overview History Ultrasound Physics Clinical Use and Limitations Normal and Pathologic M Mode Findings Additional Applications Left Ventricle Mitral Valve Aortic Valve Pulmonic Valve Tricuspid Valve Pericardium IVC Clinical Use and Limitations
  • 17. Clinical Use High temporal resolution: • most useful in delineating the path of structures moving at a high velocity • Useful for precise timing of events within the cardiac cycle • subtle changes are more readily appreciated with m-mode than with two-dimensional or three- dimensional methods
  • 18. Clinical Use High axial resolution: • allows the resolution of delicate cardiac structures (e.g. valve leaflets) which are difficult to resolve, especially with transthoracic echocardiography
  • 19. Clinical Use may include more precise measurement of cardiac chambers (provided they are obtained on-axis) independent motion of valvular vegetations early closure or early opening of valve structures with respect to timing in the cardiac cycle identification of prosthetic valves and their function assessment of paradoxical interventricular septal motion and dyssynchrony of the left ventricle fluttering of valve leaflets seen in association with valvular regurgitation The exaggerated motion, as well as restricted motion, of various cardiac structures
  • 20. Limitations having to draw conclusions in one dimension about a three-dimensional structure measurements are dependent on the identification of clearly defined borders, which may not be obtainable in technically challenging patients If the measurements are not well standardized, M- mode measurements can be highly variable With respect to m-mode’s derived ejection fractions, calculations may not be accurate when regional wall motion abnormalities are present
  • 21. Normal and Pathologic M Mode Findings
  • 22. Overview History Ultrasound Physics Clinical Use and Limitations Normal and Pathologic M Mode Findings Additional Applications Left Ventricle Mitral Valve Aortic Valve Pulmonic Valve Tricuspid Valve Pericardium IVC Left Ventricle
  • 23. Normal M-Mode Examination of the Left Ventricle Moss & Adams 9th ed • Pediatric ASE guidelines recommend use of the parasternal short-axis views to obtain LV measurements • If the measurements are not well standardized, M-mode measurements can be highly variable • Pediatric ASE recommendations suggested using measurements obtained from two-dimensional (2-D) imaging in place of M-mode for LV chamber quantification • Downside: • lower temporal resolution especially in patients with high heart rates • normal published Z scores based on M mode measurements
  • 24. Normal M-Mode Examination of the Left Ventricle Moss & Adams 9th ed • Recent data from the Pediatric Heart Network indicated that the LV dimensions could be measured with high reproducibility by both methods and that agreement was high between the two methods (M-Mode vs. 2-D) • For calculation of shortening fraction (SF) using M-mode was shown to be more reproducible and it was shown that measurements differed between both techniques
  • 25. Normal M-Mode Examination of the Left Ventricle • Maximum short-axis dimension • Young patients: level of the MV leaflet tips or chordae • Older patients and adults: more apically at the level of the papillary muscles • Linear measurements characterize LV size only in one dimension • may misrepresent an abnormally shaped chamber • Short-axis diameters should be considered a surrogate for LV size only when the LV short-axis geometry is circular, a condition often not met in patients with CHD or other abnormal hemodynamic states
  • 26. Normal M-Mode Examination of the Left Ventricle • left ventricular dimensions: measured at end-diastole and end-systole • left ventricular wall thicknesses (IVS and PW) : measured at end diastole • end-diastole: defined as the frame at which the MV closes • end-systole: the frame preceding MV opening
  • 27. Normal M-Mode Examination of the Left Ventricle • For the accurate measurements of cardiac chambers, leading-edge to leading-edge technique should be used • The values should be indexed to the body surface area (BSA) and then expressed as Z scores
  • 28. NEW ASE RECOMMENDATION Current guidelines for chamber, annular, and vessel quantification involve measurements of intraluminal dimensions from one inner edge to the opposite inner edge
  • 34. Hypertrophic Cardiomyopathy Approach to Echo diagnosis of HCM Use of M Mode Confirm LV hypertrophy Septal hypertrophy Assessment of LVOT obstruction Detect mid-systolic (premature) closure of the aortic valve due to outflow track obstruction Systolic Anterior Motion (SAM) Seen on Mmode Assessement of systolic and diastolic LV function and LA size LVEF and FS
  • 36. • Contractile dysfunction • Ventricular dilatation • Thin myocardial wall • Dyssynchrony Normal Dilated Cardiomyopathy
  • 37. Dilated Cardiomyopathy: septal-to-posterior wall motion delay (SPWMD) • PSAX view at the level of the papillary muscles • time interval between peak systolic inward contraction of the septum and posterior wall • SPWMD of ≥130 ms predicted a response to CRT • Subsequent analyses have, however, demonstrated limited predictive value Bleeker et al. 2007. Am J Cardiol,
  • 38. Paradoxical Septal Wall Motion movement of the interventricular septum away from the left ventricular free wall during systole opposite of its normal movement which is inward toward the left ventricle / or the left ventricular free wall during systole
  • 39. Paradoxical Septal Wall Motion Causes • Atrial septal defect • Constrictive pericarditis • Post heart surgery • LBBB • Mitral stenosis • Pericardial effusion (large) • Pulmonary hypertension • Repaired Tetralogy of Fallot • Right ventricular hypertrophy • Right ventricular pacing, particularly from the right ventricular outflow tract due to contraction of the RV before the LV • Right ventricular tumor • Right ventricular volume overload
  • 40. Overview History Ultrasound Physics Clinical Use and Limitations Normal and Pathologic M Mode Findings Additional Applications Left Ventricle Mitral Valve Aortic Valve Pulmonic Valve Tricuspid Valve Pericardium IVC Left Ventricle Mitral Valve
  • 41. Normal M-Mode Examination of the Mitral Valve • obtained from the parasternal long-axis imaging plane • The m-mode cursor is placed perpendicular to the long axis of the left ventricle at the level of the tips of the mitral leaflet • The anterior leaflet and posterior leaflet are noted to open fully in diastole and close completely during systole
  • 42. Normal M-Mode Examination of the Mitral Valve
  • 43. Mitral Stenosis • Decreased EF slope • Paradoxical anterior diastolic motion of the PMVL • Separation between leaflets is decreased • Leaflet tips bright and thickened • Early diastolic dip of IVS • Reduced MV leaflet excursion
  • 45. Mitral Valve Prolapse • Thick redundant mitral valve leaflets • Mid to late systolic / holosystolic sagging back of the anterior, posterior or both MV from C-D point of MV
  • 47. Mitral Valve Prolapse Systolic bowing of the posterior mitral valve leaflet
  • 48. Flail MV leaflet • This may occur as a result of chordal rupture (due to degeneration) or to papillary muscle dysfunction • The posterior leaflet shows erratic movement, rather than the normal ‘W’ pattern • Coarse diastolic fluttering of mitral leaflets
  • 49. Flail MV leaflet • Flail mitral leaflet may appear within LA during systole
  • 50. Infective endocarditis • Valve leaflet appear thickened, “smudged”, “shaggy” • Vegetation on a valve leaflet usually doesn’t restrict valve motion
  • 52. LA Myxoma • Bright hyperdensity in mitral orifice • Echo free space at anterior mitral leaflet at onset of diastole prior to dense echoes from tumor • Functional MS • Blunted E point of the mitral valve • Decrease E-F slope
  • 54. Hypetrophic Cardiomyopathy • In diastole, the mitral valve may be normal • In systole the entire MV apparatus moves anteriorly producing a characteristic bulge touching the interventricular septum • systolic anterior motion (SAM) of the MV
  • 56. B-bump • The B bump on mitral valve is predictive of significant elevation of LVEDP • Marker of LV dysfunction • Mitral B bump is essentially a late diastolic phenomenon in which the leaflets keep a semi-open position without LV inflow effectiveness • The resultant LA pressure work over mitral leaflets, pushing them toward LV generating the bump Araujo et al. 2004. Int J Cardiol. 95(1):7-12
  • 58. E-point septal separation (EPSS) • the distance between the anterior mitral valve leaflet and the interventricular septum in early diastole • an EPSS >7 mm is 100% sensitive for a severely depressed ejection fraction (EF <30%) • as derived from comparison with MRI, EPSS roughly equates ejection fraction McKaigney et al. 2014. The American journal of emergency medicine. 32 (6): 493-7
  • 59. Overview History Ultrasound Physics Clinical Use and Limitations Normal and Pathologic M Mode Findings Additional Applications Left Ventricle Mitral Valve Aortic Valve Pulmonic Valve Tricuspid Valve Pericardium IVC Left Ventricle Mitral Valve Aortic Valve
  • 60. Normal M-Mode Examination of the Aortic Root, Aortic Cusp Separation, and Left Atrial Dimension • Traditionally, m-mode measurements have been used to quantify aortic root size, aortic valve cusp separation, and left atrial dimensions • These measurements are obtained from the parasternal long-axis imaging plane • m-mode measurements are made leading edge to leading edge • The m-mode cursor is placed perpendicular to the structure being measured
  • 61. Normal M-Mode Examination of the Aortic Root, Aortic Cusp Separation, and Left Atrial Dimension • Aortic root: measured in end-diastole, just before the onset of the QRS complex • Aortic valve cusp separation • measured in midsystole • The normal appearance of the aortic cusps during systole is that of an “open box,” which reflects holosystolic opening of the valve leaflets • Left atrium : measured during ventricular systole or atrial diastole, when the left atrium is maximally filled with blood
  • 62. Aortic Valve • The aortic valve has 3 cusps–right coronary, left coronary and non-coronary cusps • The cusps imaged in the PLAX view are the right coronary and the non-coronary cusps • Leaflet may show fine systolic fluttering in healthy individuals
  • 63. Bicuspid Aortic Valve • M-mode echocardiography can often be useful in helping establish the diagnosis of a bicuspid aortic valve • The classic appearance: eccentric closing of the valve leaflets • strongly suggestive of a bicuspid aortic valve, although in some cases, bicuspid aortic valves may open symmetrically
  • 65. Aortic Stenosis • Thickened, calcified leaflets • Dense, persistent echoes replacing the normal motion patterns • Post-stenotic aortic root dilation • LVH • Eccentrically placed diastolic closure line (BAV)
  • 66. Aortic Regurgitation • Diastolic fluttering of AMVL due to AI jet turbulence • Diastolic fluttering of aortic valve • Premature closure of mitral valve • Premature opening of aortic valve • Dilated LV • Increased duration between E and A peaks
  • 69. Overview History Ultrasound Physics Clinical Use and Limitations Normal and Pathologic M Mode Findings Additional Applications Left Ventricle Mitral Valve Aortic Valve Pulmonic Valve Tricuspid Valve Pericardium IVC Left Ventricle Mitral Valve Aortic Valve Pulmonic Valve
  • 70. Normal M-Mode Examination of the Pulmonic Valve • The normal m-mode recording of the pulmonic valve is usually obtained from the parasternal short-axis view • can also be obtained from the right ventricular outflow tract view and main pulmonary artery and bifurcation view
  • 71. Normal M-Mode Examination of the Pulmonic Valve • Like the normal aortic valve, the normal pulmonic valve opens throughout systole and has the appearance of “an open box” Letter designation • a = atrial contraction • b = onset of ventricular systole • c = ventricular ejection • d = during ventricular ejection • e = end of ventricular ejection
  • 72. Pulmonary Hypertension • loss of A-dip of pulmonary valve • Flying W sign
  • 74. Pulmonary Stenosis • increase depth of pulmonary valve “a” wave (increased a-dip)
  • 75. Overview History Ultrasound Physics Clinical Use and Limitations Normal and Pathologic M Mode Findings Additional Applications Left Ventricle Mitral Valve Aortic Valve Pulmonic Valve Tricuspid Valve Pericardium IVC Left Ventricle Mitral Valve Aortic Valve Pulmonic Valve Tricuspid Valve
  • 76. Normal M-Mode Examination of the Tricuspid Valve • The normal m-mode recording of the tricuspid valve is obtained from the right ventricular inflow view • Usually, only the anterior leaflet of the tricuspid valve is transected by the m-mode cursor
  • 77. M-mode letter designations for the tricuspid valve are as follows: D = onset of diastole, E = maximal opening of the leaflet, F = most posterior position of the leaflet, E–F slope = closing motion of the leaflet, A = leaflet reopening with atrial contraction, and C = leaflet closure following ventricular systole.
  • 78. M mode findings in Tricuspid Stenosis • Thickened TV leaflets • Decreased EF slope of the Anterior TV leaflet • Anterior motion of the Posterior TV leaflet • Decreased/absent A wave of the Anterior TV leaflet • Steep A-C slope of the TV • Pulmonary HPN due to coexisting MV disease
  • 79. Ebsteins Anomaly • Paradoxical septal motion • Dilated RV • Delayed closure of the TV leaflets >65 ms after MV closure • Increased velocity and amplitude of Anterior TV leaflet motion
  • 80. Ebsteins Anomaly • Paradoxical septal motion • Dilated RV • Delayed closure of the TV leaflets >65 ms after MV closure • Increased velocity and amplitude of Anterior tV leaflet motion
  • 82. Overview History Ultrasound Physics Clinical Use and Limitations Normal and Pathologic M Mode Findings Additional Applications Left Ventricle Mitral Valve Aortic Valve Pulmonic Valve Tricuspid Valve Pericardium IVC Left Ventricle Mitral Valve Aortic Valve Pulmonic Valve Tricuspid Valve Pericardium
  • 84. Cardiac Tamponade •Compressed RV •Ventricular interdependence: increase in RV dimension with inspiration and simultaneously decrease in LV dimension during inspiration •Mitral valve: •Decrease EF slope with inspiration •Decrease DE amplitude with inspiration •RV diastolic collapse (specific) •RA diastolic collapse (sensitive) •Dilated IVC with blunted respiratory changes
  • 85. Cardiac Tamponade: RA diastolic collapse collapse lasting more than 1/3 of systole is almost 100% sensitive and specific for tamponade
  • 86. Cardiac Tamponade: RV Diastolic Collapse
  • 90. Cardiac Tamponade • The increased pericardial pressure limits the ability of the right ventricular free wall to expand and accommodate the inflow of blood during inspiration • The result is increased bowing of the ventricular septum into the left ventricle as blood fills the right heart, resulting in a lower left ventricular end diastolic volume, a lower stroke volume and resulting lower systolic pressure. • In more simple terms, in a non-compliant pericardial space, for the right heart to fill more in inspiration, the left heart must fill less
  • 95. Constrictive pericarditis • Pericardial thickening • Paradoxical septal motion • Septal bounce ( abrupt displacement of the IVS during early diastole) • Flattening of mid & late diastolic motion of the posterior LV wall • Rapid early diastolic, or E-F slope of the mitral valve • Rapid downward motion of the posterior aortic wall in early diastole • Premature opening of pulmonary valve • Dilated IVC with blunted respiratory changes
  • 96. Ventricular interdependence in constrictive pericarditis • the normal drop in filling pressures will be blunted by the thick pericardium  prevent normal decrease in pressure from reaching the ventricles • Net effect is decreased gradient for LV filling • The opposite occurs during expiration. extrapericardial intrapericardial
  • 97. Septal bounce • sign of ventricular interdependence • ventricles are constricted (tethered by the pericardium)  motion of the ventricular walls is markedly reduced and the volume of the heart is fixed • Changes in ventricular volumes and pressures are then reflected through deviations of the septum
  • 101. inferior vena cava plethora (maximum diameter ≥21 mm and degree of inspiratory collapse <50%
  • 102. Overview History Ultrasound Physics Clinical Use and Limitations Normal and Pathologic M Mode Findings Additional Applications Left Ventricle Mitral Valve Aortic Valve Pulmonic Valve Tricuspid Valve Pericardium IVC Left Ventricle Mitral Valve Aortic Valve Pulmonic Valve Tricuspid Valve Pericardium IVC
  • 106. Tricuspid annular plane systolic excursion (TAPSE) • Measured in the apical four- chamber view • systolic longitudinal displacement of the lateral tricuspid annulus toward the apex
  • 107. Mitral annular plane systolic excursion (MAPSE) • Tapse • mapse
  • 108. Color doppler m-mode imaging Used to determine velocity of propagation (Vp) of LV inflow Determination of width of AR jet Duration of MR
  • 110. Duration of mitral regurgitation
  • 113. • The left ventricular (LV) flow velocity propagation measured by colour M-mode Doppler (Vp) is a useful function diastolic index, with some advantages over pulsed Doppler • It might be used to differentiate a normal from a pseudonormal LV filling pattern

Editor's Notes

  • #12: RESOLUTION Resolution is the ability to distinguish between two objects in close proximity. It has at least two components: spatial and temporal Spatial resolution is defined as the smallest distance that two targets must be separated by for the system to distinguish between them. It, too, has two components: Axial resolution refers to the ability to differentiate two structures lying along the axis of the ultrasound beam (i.e., one behind the other), and lateral resolution refers to the ability to distinguish two reflectors that lie side by side relative to the beam . 9. • A third component of resolution is called contrast resolution. Contrast resolution refers to the ability to distinguish and to display different shades of gray within the image. This is important both for the accurate identification of borders and for the ability to display texture or detail within the tissues. 10. • Temporal resolution, or frame rate, refers to the ability of the system to accurately track moving targets over time. It is dependent on the amount of time required to complete a scan, which in turn is related to the speed of ultrasound and the depth of the image as well as the number of lines of information within the image. Generally, the greater the number of frames per unit of time, the smoother and more aesthetically pleasing the realtime image. Factors that reduce frame rate, such as increasing depth of field, will diminish temporal resolution. This is particularly important for structures with relatively high velocity, such as valves. Temporal resolution is the main reason that M-mode echocardiography is still a useful clinical tool
  • #13: Standard views are often categorized as ‘‘long axis’’ or ‘‘short axis’’,11 and these are described in Table 1. General optimization techniques in two- dimensional (2D) imaging have been outlined previously for children.11 Several technical factors can influence the accuracy of spatial measure- ments: (1) axial resolution parallel to the ultrasound beam is superior to lateral resolution perpendicular to the beam, so views allowing for linear axial measurements are better than those for which only lateral mea- surements are available (parasternal views are better than apical views for the aortic annulus); (2) lateral resolution degrades with increasing distance secondary to beam spread, so the transducer should be posi- tioned as close as possible to a structure when only a lateral measure- ment is available; and (3) for large image depths, the ultrasound resolution often exceeds the pixel resolution of the image display, so de- creasing the image depth or magnifying the region of interest can often alleviate the limitations of the monitor resolution.
  • #19: With m-mode echocardiography, the strength of the reflecting echo structure is demonstrated by the brightness of the image on the ultrasound screen. Time is represented in milliseconds; with respect to the cardiac cycle (systole and diastole), it is displayed on the horizontal axis. Distance of the reflecting cardiac structure is displayed on the vertical axis. EDV, End diastolic volume; IVS, interventricular septum; LV, left ventricle; PSAX, parasternal short axis; PW, posterior wall; RV, right ventricle.
  • #20: With m-mode echocardiography, the strength of the reflecting echo structure is demonstrated by the brightness of the image on the ultrasound screen. Time is represented in milliseconds; with respect to the cardiac cycle (systole and diastole), it is displayed on the horizontal axis. Distance of the reflecting cardiac structure is displayed on the vertical axis. EDV, End diastolic volume; IVS, interventricular septum; LV, left ventricle; PSAX, parasternal short axis; PW, posterior wall; RV, right ventricle. Courtesy of Bernard E. Bulwer, MD, FASE.
  • #23: This figure illustrates the most common m-mode measurements obtained from the parasternal long-axis view, including measurements of the aortic root, cusp separation of the aortic valve leaflets, mitral valve opening and closure, and left ventricular measurements including internal dimensions in diastole and systole and septal and posterior wall thickness in end-diastole. Courtesy of Bernard E. Bulwer, MD, FASE.
  • #33: Quantitative assessment of each structure should be performed in multiple views, and orthogonal planes should be used for noncircular structures such as the atrioventricular (AV) valves. Early reports based on M-mode echocardiography recommended measurements from the leading edge of the near-field reflector to the leading edge of the far-field reflector,12 and normative data for the proximal aorta in adults have involved leading edge–to–leading edge measurements.13 However, current guidelines for chamber, annular, and vessel quanti- fication involve measurements of intraluminal dimensions from one inner edge to the opposite inner edge.14 In addition, published pediat- ric normative databases based on 2D echocardiography have used in- ner edge–to–inner edge measurements of vessel diameters.15-17 There are two important caveats with these measurements: vascular diameters should be perpendicular to the long axis of the vessel, and valvar and vascular diameters should be measured at the moment of maximum expansion. In other words, the inferior vena cava (IVC) diameter should be measured during exhalation, the mitral valve (MV) and tricuspid valve (TV) annular diameters in diastole, and the aortic valve (AoV) and pulmonary valve (PV) annular diameters as well as arterial diameters in systole. These recommendations are based on hemodynamic considerations, correspond to the methodologies used in published pediatric normative databases,15-17 and often differ from the quantification approach used in adults.1,13
  • #34: M-mode echocardiography from a parasternal short-axis view showing the left ventricular cavity over the cardiac cycle (see ECG tracing) during systole and diastole. Abbreviations: IVS, interventricular septum; LV, left ventricle; LVEDD, left ventricle end-diastolic dimension; LVESD, left ventricle end-systolic dimension; LVPW, left ventricle posterior wall.
  • #41: M-mode echocardiography obtained from a patient (left image) with normal left ventricular systolic function (FS = 34% and EF = 65%) and in a patient (right image) with dilated cardiomyopathy with severe left ventricular systolic dysfunction (FS = 8% and EF = 16%), LVEDD with green arrow and LVESD with blue arrow. Abbreviations: EF, ejection fraction; FS, fractional shortening; LVEDD, left ventricle end-diastolic dimension; LVESD, left ventricle end-systolic dimension.
  • #44: In congenital heart disease, hypokinesia and dyskinesia of the interventricular septum occur in the presence of RV volume loading (e.g., large atrial septal defect). This can cause paradoxical septal motion with the septum moving away from the inferolateral wall during systole (Fig. 13.7). Paradoxical septal motion can also be present in the immediate postoperative (post bypass) period and in the presence of left bundle branch block where maximal systolic motion of the inferolateral wall and septum do not occur simultaneously.
  • #45: In congenital heart disease, hypokinesia and dyskinesia of the interventricular septum occur in the presence of RV volume loading (e.g., large atrial septal defect). This can cause paradoxical septal motion with the septum moving away from the inferolateral wall during systole (Fig. 13.7). Paradoxical septal motion can also P.344 be present in the immediate postoperative (post bypass) period and in the presence of left bundle branch block where maximal systolic motion of the inferolateral wall and septum do not occur simultaneously.
  • #57: Torn chordae amvl sec to bac endocarditis
  • #68: Normal m-mode examination of the aortic root, aortic valve cusps, and left atrium. Measurements are obtained in the parasternal long-axis imaging plane. Note the holosystolic opening of the aortic valve cusps. By convention, m-mode measurements are made leading edge to leading edge, which differs from two-dimensional measurements. The m-mode cursor is placed perpendicular to the aortic valve leaflets. Ao, Aorta; AoR, aortic root; AV, aortic valve; Cusp, aortic leaflet separation; LA, left atrium; Root, aortic root.
  • #70: M-mode examination of a bicuspid aortic valve obtained from the parasternal long-axis view. Note that in this case the closing of the valve is asymmetric (arrow) . If present, this may be an important clue in establishing the diagnosis of bicuspid aortic valve. In some situations, bicuspid aortic valves may open symmetrically. ant, Anterior; pos, posterior.
  • #74: Figure 6 (A) Example of aortic regurgitation (AR) jet impinging on the anterior mitral valve leaflet with a reverse doming of the anterior mitral valve leaflet; (B) M-mode recording showing the fluttering motion of the anterior mitral leaflet in a patient with severe AR.
  • #79: Normal m-mode examination of the pulmonic valve obtained from the parasternal short-axis view. This recording may also be obtained from the parasternal right ventricular outflow view and the main pulmonary artery and bifurcation view. Note the holosystolic opening of the cusps, similar to the aortic valve. Often, m-mode of the pulmonic valve only transects the right posterior leaflet. In this example, both the anterior and right posterior leaflets are transected. The m-mode letter designations for the pulmonic valve are as follows: (a), atrial contraction; (b), onset of ventricular systole; (c), ventricular ejection; (d), during ventricular ejection; (e), end of ventricular ejection.
  • #86: Normal m-mode examination of the tricuspid valve obtained from the right ventricular inflow view. Usually only the anterior leaflet of the tricuspid valve is transected. RA, Right atrium; RV, right ventricle; TV, tricuspid valve. The m-mode letter designations for the tricuspid valve are as follows: (D), onset of diastole; (E), maximal opening of the leaflet; (F), most posterior position of the leaflet; (E–F slope), closing motion of the leaflet; (A), leaflet reopening with atrial contraction; (C), leaflet closure following ventricular systole.
  • #95:  collapse lasting more than 1/3 of systole is almost 100% sensitive and specific for tamponade. 
  • #99: As we inhale, intrapleural pressure drops; there is a decrease in intrathoracic pressure that promotes venous inflow into the chest increasing right heart filling. However, this does not equate to an increased filling of the left heart during inspiration. This is because, as one inhales, the lungs expand and pull radial traction on the pulmonary vasculature increasing its capacitance, momentarily sequestering blood in the chest, and dropping blood flow to the left heart, decreasing pre-load and consequently cardiac output. The opposite occurs during expiration, thus systolic pressure normally decreases during inspiration and increases during expiration. 
  • #106: During normal inspiration, both intrapleural and intrapericardial pressure fall in tandem to roughly the same degree, and this pressure drop is transmitted to the cardiac chambers. In constrictive pericarditis, the thickened pericardium will prevent the normal decrease in pressure from reaching the ventricles; thus, the normal drop in filling pressures will be blunted by the thick pericardium. This is important because in the pulmonary veins (which are extrapericardial), the pressure drop will be greater than left ventricular diastolic pressure drop (intrapericardial), and the gradient for left ventricular filling will be decreased, resulting in decreased left ventricular filling. The opposite occurs during expiration.
  • #108: M-mode echocardiography shows the characteristic findings of septal bouncing ("double components"; arrow) with an increased pericardial thickness (arrowhead)
  • #122: VP in a patient with DCM with flow propagation velocity <45 cm/s: impaired relaxation