The document summarizes the results of an opportunity survey completed by directors of water centers in the Middle East and North Africa region. It received responses from 15 centers. The survey asked about key areas for applied water research, private sector involvement, research capacity strengthening, and information sharing. The top research strengths of centers were groundwater, water supply/sanitation/utilities, water use efficiency and productivity, non-conventional water sources, and water-energy-food security relationships. The biggest regional water challenges were similar. Based on the responses, the document proposes initial thematic partnerships between centers in areas like water policy/governance and groundwater management.