Twelve workers had their biomechanical exposure assessed through recordings of trapezius muscle activity and posture during a 4-hour workday. Handling tasks, such as manual box handling, demonstrated the highest biomechanical demand on the upper body, with high peak loads on the upper trapezius muscle and forward flexion of the upper back. However, handling tasks also showed high variation in exposure. Interventions aimed at decreasing loads in handling tasks can help reduce peak loads and risks of musculoskeletal disorders in the upper limbs. The study assessed biomechanical exposure during regular job tasks in a real industrial context to understand how manual box handling compares to other tasks.