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The MEMOTEXT® mobile heath
experience.
       From product to methodology…




                                            Amos Adler M.Sc.
                     MEMOTEXT Personalized Adherence Solutions
From product to methodology



   –   Problem/issue
   –   Methodology
   –   Outcomes/Results
   –   Best practices
   –   Challenges
mHealth Behavior Change Lessons Learned
The Problem:
Technology ≠ behavior change

Patient Adherence / Medication Compliance and technology interventions
•   Systemic Adoption
•   Patient Adoption
•   Everyone is different + people change
•   Does it scale?


                           1.   How patients interact between health and
                                technology
                           2.   How marketing must meet with health
                           3.   How academia interacts with commercialism to
                                become ‘agile’

                                            mHealth is a series of intersections.
                                                                         ~Roni Zeiger
Adherence is a
discipline, MEMOTEXT is a
methodology
1.   Systemic
     Adoption
2.   Patient
     Adoption                Analysis &   CATWOE
2.   Everyone is            Stakeholder
     different +             Visioning
     people
     change
3.   Does it scale?   Intervention        Evidence Base
                       Validation



                              Design




                        Deploy




                              Iterate




                                 Requirements             Intervention
Methodology  Condition specific intervention design

          Condition/    Literacy     Self Efficacy          Depression          Knowledge Test
          Medication    Barriers     Barriers               Barriers
          Type II       Adams et     Sarkar et al., 2006;   (Katon et al.,     Depression screen
          Diabetes      al., 2009;   Aljasem et al.,        2009). Likewise,
                        Jeppesen     2001; Kavanagh et      Moreau et al.      Anxiety/Distress
                        et al.,      al., 1993).            (2009)                  Scale
                        2009
                                                                                 QoL SF36/12
          Anticoag/AF   (Higgins &   Chu; Kim; Kwang;
                        Regan,       Park, 2009)                               Self Efficacy Scale
                        2004).

                                                                                       Hx
            …integrating with individual patient needs for
            education, incentives, interactive coaching,
            motivation, reminder cues and
            stakeholder/peer support.
Assessment + Intervention



                                                     Iterative Assessment  Individualized communications
                                                     Understand needs, motivations, behaviours.

                                                     •   Iterative screening instruments used to determine personal
           Patient Recruitment                           barriers to adherence.
     engage patient populations via
                                                     •   Patients assessed throughout program.
               partners, HCPs and
         communications planning.                    •   Individual Assessment Segmentation & Re-Segmentation every
                                                         6-12 weeks. Determines intervention content


RECRUITMENT                             ASSESSMENT                    INTERVENTION                          ANALYTICS

          Depression screen
                      Knowledge Test
                              Anxiety/Distress
          Self Efficacy Scale
                                   Scale                              Stage           Medicines
                                                                       of             Literacy
                     QoL SF36/12
                                                                     Change
                                   Hx

                                                                                                  Self
                                                          Depression                            Efficacy
                                                                                 Condition
                                                                                 Literacy
Speech, Social, Mobile.                                           What is MEMOTEXT?
                                 Listen, guide, motivate.
                                                                                                       Phys.     Lifestyle

       • Self-learning, multi-media trusted health                                                    Activity
                                                                                                       10%
                                                                                                                    2%


                interventions tailored to customer                                               Med Lit.
                                                                                                  22%
                                                                                                                      MI 30%

                     segment and individual need.                                                     Diet Lit.
                                                                                                                CBT 25%
                                     Behavioral Economic                                                8%
                                     and Intervention Models:
                                                                •   Health Belief Model
                                                                •   Irrational Health Beliefs
                                                                •   Theory of Planned Behavior
                                                                •   Theory of Reasoned Action



RECRUITMENT         ASSESSMENT                        INTERVENTION                                     ANALYTICS


                    -   Medicines Education
                    -   Side Effect Information
                                                                      …integrating persuasive
                    -   Tailored Condition Literacy                   methods with individual patient
                    -   Inspirational/Motivational                    needs for
                    -   Automated Motivational                        education, incentives, interactive
                        Interviewing
                                                                      coaching, motivation, reminder
                                                                      cues and stakeholder/peer
                                                                      support.
Outcomes




I have not failed. I've just found 10,000 ways
that won't work.
~ Thomas A Edison
The numbers tell the story




 >20 ongoing programs/trials
 3Years avg. duration of a program
 85-95% program retention rates
 67% average DAILY patient participation rate.   Program Type       Voice        SMS
                                                 Contraception      12%          88%
                                                 (N.America)

                                                 Multiple           64%          36%
                                                 Sclerosis
                                                 (Canada)

                                                 Bone Health        36%          64%
                                                 (US)

                                                 T2 Diabetes        18%          82%
                                                 (UK)

                                                 Media selection is condition, demographic and
                                                 geography specific.
Randomized Clinical Trial MEMOTEXT & Johns
Hopkins University

• Monitor           • Poor              • MEMOTEXT            n= 428
  Adherence           Adherence           group               glaucoma
                    • Good              • Control group       patients
                      Adherence                               treated
                                                              with once
3 months            Randomize            3 months             daily       Presented MHealth2011:
                                                              therapy.    What Really Works
                                                                          Stanford University May
Johns Hopkins University: is using the MEMOTEXT® platform to provide an   2011
automated, customized and interactive adherence solution for glaucoma -
a study entitled "The Impact of Automated Dosing Reminders on             Presented at Kaiser
Medication Adherence using HealthVault".                                  Permanente – Gallery of
                                                                          Innovation October 2011
Launched: June 2009
Recruitment Channel: JHU Research / Wilmer Eye Clinic                     March 2011 annual meeting
Scope: Reminders for Travatan                                             of American Glaucoma
                                                                          Society.
Results:
Automated reminders linked to a personal health record are a practical    This project received
option to improve adherence                                               funding from the
                                                                          Microsoft
Significantly improve adherence with daily medications: Intervention      HealthVault Be Well
group increase adherence from 51% to 67% adherence p. 0.003               Fund.
(Electronic Monitoring of Dosing)

Control 49-50% p 0.83                                   11
The numbers tell the story




 79% of patients rate programs very
 highly
 17% + change in patients rating
 confidence in self management (over 18
 months)                                   Effect on Medication              Average Change in
                                           Possession Ratios 3X daily          Total Number of
 76% of patient self-report feeling        regimen medications               Dispensed Records
                                                                                      %
 better, healthier and happier since
 starting a T2 Diabetes program (over 18
                                           High Medication Possession Rate     + 1.5 - 3%
 months)                                   (MPR) >80%


                                           Medium MPR 33% to 80%               +20%-25%

                                           Low MPR <33%                           +50%
Best Practices




          1.     Everyone is different
          2.     Different conditions require different
                 behavioral interventions. Commonalities are
                 emerging though.
          3.     People change over time, they learn, they
                 ebb, they flow
          4.     The most appropriate technology for the user.
                 Fit the solution to the problem, not the other
                 way around.
          5.     Relevant, intense, interactive guided
                 dialogues throughout the course of
                 treatment can positively modify behavior.
          6.     Health Belief Model and other health             The Health Belief Model
                 communication models help create                 emphasises that health
                 personalization.                                 behaviours are influenced by
                                                                  i) perception of the
          7.     Personalization creates RELEVANCE.               individual’s susceptibility to a
                 Relevance keeps the conversation going.          health problem,
                                                                  ii) perception of the severity
          8.     Evidence based personalization is required for   or seriousness
                 white-coat credibility.                          iii) perception of the
                                                                  effectiveness and tolerability
                                                                  of the treatment
                                                                  iv) cues to take action.
MEMOTEXT Methodology – Stakeholder
     buy-in
                                         No silver bullet – just plain old hard work

               Analysis &                What works:
              Stakeholder
               Visioning                 • Distribute and situate recruitment
                                             • multipoint/multichannel
       Intervention                      • Cross-organizational buy-in
        Validation
                                             • front-line champions
                                         • Internal communications rigour
                Design
                                             • Measure, monitor, pivot
                                         • Time to measure results
                                         • Ability to iterate
         Deploy
                                         • Stakeholder Communications Planning

                                         mHealth to MEMOTEXT means:
                Iterate
                                         • Organizational change
                                         • Systems thinking
                                         • Medical Science
                                         • Behavioral Science & Behavioral Economics
                                         • Informatics
                                         • Technology = 30%

RECRUITMENT                 ASSESSMENT      INTERVENTION                 ANALYTICS
The challenges


                 • The biggest challenges in mHealth
                   are not necessarily intervention
                   efficacy.
                 • Although
                    – Current evidence is stronger for texting
                      than apps in improving clinical
                      outcomes/QOL indicators, but
                      numerous studies are underway


                 • The biggest challenge we have seen
                   is not:
Although…
Bad      “Most technology needs to go
         to finishing school”
Design                      ~ David Rose
Lessons learned
The biggest challenge is: Behavior Change Ground ZERO


RECRUITMENT/ADOPTION
  We Want YOU to:
  -    Comply
  -    Download our app
  -    Like our page
  -    Sign up to our program
  -    Buy more stuff
  -    Give us your data
  -    Admit that you need help!
-   Competing for MindShare with
    - Professional Marketing
    - Overwhelmed and overloaded
       by apps and technology
RECRUITMENT/ADOPTION hierarchy

                                   Despite best efforts to enrol patients in
                                   mobile/text programs, patients get
                                   defensive when approached.




                                                                  Perceived
                                                                  as medical advice
                                                                  by the patient

                                                   “I think you
                                                   should consider
                                                   this support
                                                   program - try it
1:5 recruitment ratio by Physican/Clinician        out ”

                                                                      Perceived
                                            “I think you should       as “what are
1:20 recruitment ratio by Pharmacist        consider this
                                            support program -
                                                                      you trying
                                                                      to sell me?”
                                            try it out ”
Evidence based personalization and
gamification of healthcare interactions.



Call me maybe?

amos@memotext.com
Twitter: @MEMOTEXT
www.memotext.com
1.877.Memo.txt

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mHealth Behavior Change Lessons Learned

  • 1. The MEMOTEXT® mobile heath experience. From product to methodology… Amos Adler M.Sc. MEMOTEXT Personalized Adherence Solutions
  • 2. From product to methodology – Problem/issue – Methodology – Outcomes/Results – Best practices – Challenges
  • 4. The Problem: Technology ≠ behavior change Patient Adherence / Medication Compliance and technology interventions • Systemic Adoption • Patient Adoption • Everyone is different + people change • Does it scale? 1. How patients interact between health and technology 2. How marketing must meet with health 3. How academia interacts with commercialism to become ‘agile’ mHealth is a series of intersections. ~Roni Zeiger
  • 5. Adherence is a discipline, MEMOTEXT is a methodology 1. Systemic Adoption 2. Patient Adoption Analysis & CATWOE 2. Everyone is Stakeholder different + Visioning people change 3. Does it scale? Intervention Evidence Base Validation Design Deploy Iterate Requirements Intervention
  • 6. Methodology  Condition specific intervention design Condition/ Literacy Self Efficacy Depression Knowledge Test Medication Barriers Barriers Barriers Type II Adams et Sarkar et al., 2006; (Katon et al., Depression screen Diabetes al., 2009; Aljasem et al., 2009). Likewise, Jeppesen 2001; Kavanagh et Moreau et al. Anxiety/Distress et al., al., 1993). (2009) Scale 2009 QoL SF36/12 Anticoag/AF (Higgins & Chu; Kim; Kwang; Regan, Park, 2009) Self Efficacy Scale 2004). Hx …integrating with individual patient needs for education, incentives, interactive coaching, motivation, reminder cues and stakeholder/peer support.
  • 7. Assessment + Intervention Iterative Assessment  Individualized communications Understand needs, motivations, behaviours. • Iterative screening instruments used to determine personal Patient Recruitment barriers to adherence. engage patient populations via • Patients assessed throughout program. partners, HCPs and communications planning. • Individual Assessment Segmentation & Re-Segmentation every 6-12 weeks. Determines intervention content RECRUITMENT ASSESSMENT INTERVENTION ANALYTICS Depression screen Knowledge Test Anxiety/Distress Self Efficacy Scale Scale Stage Medicines of Literacy QoL SF36/12 Change Hx Self Depression Efficacy Condition Literacy
  • 8. Speech, Social, Mobile. What is MEMOTEXT? Listen, guide, motivate. Phys. Lifestyle • Self-learning, multi-media trusted health Activity 10% 2% interventions tailored to customer Med Lit. 22% MI 30% segment and individual need. Diet Lit. CBT 25% Behavioral Economic 8% and Intervention Models: • Health Belief Model • Irrational Health Beliefs • Theory of Planned Behavior • Theory of Reasoned Action RECRUITMENT ASSESSMENT INTERVENTION ANALYTICS - Medicines Education - Side Effect Information …integrating persuasive - Tailored Condition Literacy methods with individual patient - Inspirational/Motivational needs for - Automated Motivational education, incentives, interactive Interviewing coaching, motivation, reminder cues and stakeholder/peer support.
  • 9. Outcomes I have not failed. I've just found 10,000 ways that won't work. ~ Thomas A Edison
  • 10. The numbers tell the story >20 ongoing programs/trials 3Years avg. duration of a program 85-95% program retention rates 67% average DAILY patient participation rate. Program Type Voice SMS Contraception 12% 88% (N.America) Multiple 64% 36% Sclerosis (Canada) Bone Health 36% 64% (US) T2 Diabetes 18% 82% (UK) Media selection is condition, demographic and geography specific.
  • 11. Randomized Clinical Trial MEMOTEXT & Johns Hopkins University • Monitor • Poor • MEMOTEXT n= 428 Adherence Adherence group glaucoma • Good • Control group patients Adherence treated with once 3 months Randomize 3 months daily Presented MHealth2011: therapy. What Really Works Stanford University May Johns Hopkins University: is using the MEMOTEXT® platform to provide an 2011 automated, customized and interactive adherence solution for glaucoma - a study entitled "The Impact of Automated Dosing Reminders on Presented at Kaiser Medication Adherence using HealthVault". Permanente – Gallery of Innovation October 2011 Launched: June 2009 Recruitment Channel: JHU Research / Wilmer Eye Clinic March 2011 annual meeting Scope: Reminders for Travatan of American Glaucoma Society. Results: Automated reminders linked to a personal health record are a practical This project received option to improve adherence funding from the Microsoft Significantly improve adherence with daily medications: Intervention HealthVault Be Well group increase adherence from 51% to 67% adherence p. 0.003 Fund. (Electronic Monitoring of Dosing) Control 49-50% p 0.83 11
  • 12. The numbers tell the story 79% of patients rate programs very highly 17% + change in patients rating confidence in self management (over 18 months) Effect on Medication Average Change in Possession Ratios 3X daily Total Number of 76% of patient self-report feeling regimen medications Dispensed Records % better, healthier and happier since starting a T2 Diabetes program (over 18 High Medication Possession Rate + 1.5 - 3% months) (MPR) >80% Medium MPR 33% to 80% +20%-25% Low MPR <33% +50%
  • 13. Best Practices 1. Everyone is different 2. Different conditions require different behavioral interventions. Commonalities are emerging though. 3. People change over time, they learn, they ebb, they flow 4. The most appropriate technology for the user. Fit the solution to the problem, not the other way around. 5. Relevant, intense, interactive guided dialogues throughout the course of treatment can positively modify behavior. 6. Health Belief Model and other health The Health Belief Model communication models help create emphasises that health personalization. behaviours are influenced by i) perception of the 7. Personalization creates RELEVANCE. individual’s susceptibility to a Relevance keeps the conversation going. health problem, ii) perception of the severity 8. Evidence based personalization is required for or seriousness white-coat credibility. iii) perception of the effectiveness and tolerability of the treatment iv) cues to take action.
  • 14. MEMOTEXT Methodology – Stakeholder buy-in No silver bullet – just plain old hard work Analysis & What works: Stakeholder Visioning • Distribute and situate recruitment • multipoint/multichannel Intervention • Cross-organizational buy-in Validation • front-line champions • Internal communications rigour Design • Measure, monitor, pivot • Time to measure results • Ability to iterate Deploy • Stakeholder Communications Planning mHealth to MEMOTEXT means: Iterate • Organizational change • Systems thinking • Medical Science • Behavioral Science & Behavioral Economics • Informatics • Technology = 30% RECRUITMENT ASSESSMENT INTERVENTION ANALYTICS
  • 15. The challenges • The biggest challenges in mHealth are not necessarily intervention efficacy. • Although – Current evidence is stronger for texting than apps in improving clinical outcomes/QOL indicators, but numerous studies are underway • The biggest challenge we have seen is not:
  • 16. Although… Bad “Most technology needs to go to finishing school” Design ~ David Rose
  • 17. Lessons learned The biggest challenge is: Behavior Change Ground ZERO RECRUITMENT/ADOPTION We Want YOU to: - Comply - Download our app - Like our page - Sign up to our program - Buy more stuff - Give us your data - Admit that you need help!
  • 18. - Competing for MindShare with - Professional Marketing - Overwhelmed and overloaded by apps and technology
  • 19. RECRUITMENT/ADOPTION hierarchy Despite best efforts to enrol patients in mobile/text programs, patients get defensive when approached. Perceived as medical advice by the patient “I think you should consider this support program - try it 1:5 recruitment ratio by Physican/Clinician out ” Perceived “I think you should as “what are 1:20 recruitment ratio by Pharmacist consider this support program - you trying to sell me?” try it out ”
  • 20. Evidence based personalization and gamification of healthcare interactions. Call me maybe? amos@memotext.com Twitter: @MEMOTEXT www.memotext.com 1.877.Memo.txt

Editor's Notes

  • #15: What is MEMOTEXT: