Hakan Yanar MD Istanbul University Faculty of Medicine, Trauma and Emergency Surgery Service  Istanbul, Turkey
Acute mesenteric ischemia (AMI) Major cause of mortality ranging from 40-100% Mean overall mortality 74% Duron JJ, et al.  Chirurgie 1998 Mamode N, Pet al.  Eur J Surg 199 9 Scoots IG, et al.  Br J Surg 2004
Mesenteric artery embolism 30-50% Mesenteric artery thrombosis 15-30% Mesenteric venous thrombosis 5-10% Non occlusive mesenteric ischemia 10-20%
Elderly patients C omorbidities  and systemic illnesses  Herbert GS et al. Surg Clin N Am 2007
Yanar et al.  World Journal of Gastroenterology  2007 Jun 28;13(24):3350-053.
Second-look laparotomy is /was  one of the mainstays of surgical   treatment of acute mesenteric ischemia (AMI) R eoperations for assessment of intestinal viability  / anastomosis Re-exploration of the abdomen   negative explorations
Disadvanteges of second look with laparotomy Negative second look D uplicates the rates of anesthesia,  wound, and infection-related complications H igh   risk  for  hernia formation L onger   hospital stay
Replacement of second-look laparotomy  by laparoscopic intervention for those patients   minimizes these risks
Aims of laparoscopy T he exam ine the a nastomotic   line  To see  viable intestine and  intestinal  motility or absence of a necrotic segment  F ree gastrointestinal   content
C an be performed using only  one or   two  trocar   and a telescope without further disturbing the patient by using  a minimally invasive technique
Mesenteric ischemia laparoscopic second look
To whom? Low flow state Anastomosis viability-status Before – during - after thrombolytic treatment NOMI MVT
Low flow state
Anastomosis viability Terminal ileum duodenum jejenum jejenum
Before – during - after  thrombolytic treatment
NOMI
MVT
When to perform?/ timing 24 – 48 – 72 hours
Kurtoglu et al.
70/M Right lower quadrant pain Liver failure and left femoral thrombo-embolectomy 2 years ago WBC:16200, Lactat: 3.4, CRP: 196
Celiac truncus Superior mesenteric artery
Diagnostic laparoscopy
Diagnostic laparoscopy
Superior mesenteric artery Celiac truncus
Celiac stent
Second look laporoscopy
Second look
55/M Abdominal pain  AF(+) WBC: 14300, lactate: 4.1, CRP: 129
Mesenteric ischemia laparoscopic second look
Mesenteric ischemia laparoscopic second look
Mesenteric ischemia laparoscopic second look
Diagnostic laparoscopy
Before t-PA After t-PA
Second look
68/M Abdominal pain, vomiting WBC: 11400, BE: 2.4
Mesenteric ischemia laparoscopic second look
Mesenteric ischemia laparoscopic second look
Diagnostic laparoscopy
Before t-PA  After t-PA
Second look
45, M Diffuse abdomial pain Previous DVT WBC: 17900, lactate: 4.1, CRP: 148
SMV thrombosis
Diagnostic laparoscopy
Second look PO course was uneventful Protein C and Protein S deficiency WBC: 10.200, Lactate: 1.9, CRP: 18 Discharged on po day 7 with warfarine treatment
World Journal of Gastroenterology  2007 Jun 28;13(24):3350-053.
  Advantages l aparoscopic second-look Shorter operative time S horter and superficial anesthesia “ T hird” or even more explorations P revent operating room costs Prevent  “second insult” to cause  MOF
Conclusion Minimal invasive, t echnically simple procedure Should be totally replaced second look laparotomy T iming   of a second-look procedure is unclear
THANK YOU!

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Mesenteric ischemia laparoscopic second look

Editor's Notes

  • #3: Mesenteric ischemia is a major cause of mortality in surgery ranging from 40 to 100 % in some series . In a recent systemic and comprehensive review Schoots et al. f ound that the mean overall, in-hospital mortality for AMI is 74% . Although advances in diagnostic imaging, surgical technique have improved outcomes in most surgical diseases over the last several decades, mesenteric ischemia remains a highly morbid condition.
  • #4: Mesenteric ischemia occurs when visceral tissues receive inadequate blood flow. This may be a consequence of an arterial embolus or thrombosis, venous thrombosis limiting arterial inflow, and NOMI.
  • #5: The disease predominantly affects elderly patients, and they often have serious comorbidities and other systemic illnesses.
  • #6: The most common co-morbid diseases are hypertension , AF, and DM in our series.
  • #7: During the management of disease considerable number of patients undergoes reoperations for a better assessment of intestinal viability. Although great majority of these second-look operations are “negative explorations,” progressive nature of this devastating disease pushes surgeons to re-explore / reevaulate the abdomen .
  • #8: In addition the negative exploration second look laparotomy has many other disadvantages.
  • #9: For all these reasons, replacement of second-look laparotomy by laparoscopic intervention for those patients minimizes these risks
  • #10: During the second-look laparoscopy, the anastomotic line can often be examined . In a few cases, even if the anastomosis can not be visualized, seeing viable intestine and motility or absence of a necrotic segment or free gastrointestinal content is also enough to terminate the operation and remove the trocar.
  • #11: S econd-look intervention can be performed using only a trocar and a telescope without further disturbing the patient by using a minimally invasive technique
  • #13: Which patients should undergo laparoscopy
  • #14: During the initial operation if low flow state found on the bowel a 10 mm trocar can be insert for further evaluating the abdomen.
  • #18: These selected images are from a CT scan of a patient who had acute mesenteric ischemia secondary to a nearly occluded SM V and you see the small bowel thickening here. Laparoscopy will be helpful for evaulating the vaiability of bowel initialy and in suspect case second look should also be done
  • #19: Practically, re-operation may be performed within 24 h. However, we prefer to perform the second-look operation within 72 h, which promotes bowel viability and anastomotic healing. We believe this contributes to early detection of leakage and prevent peritonitis.
  • #20: In our clinic, our policy is to perform a second look laparoscopy for all patients operated on for AMI. Regardless of the clinical course of patients during the first operation when bowel viability was suspected and a low flow state was detected or bowel resection and anastomosis were performed, we performed a second-look laparoscopy within 72 h following the first operation at the bed side in the ICU or operating room.
  • #22: Total occlusion of celiac truncus and near total occlusion of SMA was found on CT Angio. To rule out the bowel ischemia diagnostic laporoscopy was performed.
  • #23: After insertion of 10 mm umbilical port using Hasson approach the camera is inserted in the abdomen. A second 5 mm port then inserted lateral to the inferior epigastric vessels. Atraumatic bowel grasper through the this port is used for retract the bowel. Rarely, in the case of a difficult adhesion on the bowel a 5mm port may also have to be inserted. The patient can return Trendelenburg position for reflecting small bowel cranially this allows and help to see the whole bowel. You can see the ischemic area on the distal small bowel and right colon. After elevation of ileocolic pedicule color of appendix was found paled.
  • #24: You can see the ischemic area on the distal small bowel and right colon. After elevation of ileocolic pedicule color of appendix was found paled.
  • #25: Because of the suspision of bowel ischemia we decided to conventional angiography. Angiography revealed 90% occlusion of celiac truncus with total occlusion.
  • #26: To increase the colleteral circulation celiac stent placed.
  • #27: Because of the accurately predict which segments of bowel remain viable, patient underwent a second-look operation 48 hours after the initial procedure . Confirmation of viability full bowel from Treitz to rectum should be done during the prosudure.
  • #31: Magnified imeges
  • #34: In 1996 the (FDA) approved the use of tPA to treat ischemic stroke in the first three hours after the start of symptoms . Than it found place in the treatment of other ischemic lesions.
  • #40: Catheter placed into SMA orifis and t PA started. Control angiography showed increased collateral circulation.
  • #41: Color of the bowel
  • #42: CT Angiography
  • #43: CT scan of the patient revealed small bowel thickening in the ileum secondary to a nearly occluded SM V. You can see thickened small bowel loops.
  • #44: We performed diagnostic laparoscopy and extensive small bowel thickening was found during the laparoscopic exploration.
  • #46: Between January 2000 and November 2005, 71 patients were operated for the treatment of AMI. The indications for a second-look were low flow state, bowel resection and anastomosis or mesenteric thromboembolectomy performed during the first operation. Regardless of the clinical course of patients, the second-look laparoscopic examination was performed 72 h post-operatively at the bed side in the ICU or operating room. In 13 patients, a second-look laparoscopic examination revealed normal bowel viability and were rescued from unnecessary laparotomies but in one patient, intestinal necrosis was detected.
  • #47: Laparoscopic second-look procedure has the following advantages: 1. Shorter operative time because of the absence of “opening” and “closing” the abdomen. 2. All you need is a shorter and superficial anesthesia , It can even be performed as a bedside procedure and sometimes without anesthesia. 3. In addition to the second one, it gives you the chance of “third” or even more explorations. 4. Using only a reusable telescope can prevent unnecessary laparotomies in terms of operating room costs. 5. There is no need to give the patient a surgical trauma as a “second insult” to cause MOF .
  • #48: Second-look laparoscopy is a minimally invasive, technically simple procedure that is performed for diagnostic as well as therapeutic purposes. L aparoscopic second-look intervention, should be totally replaced second-look laparotomy and must become the routine procedure of choice for every patient who is operated on with the diagnosis of mesenteric ischemia . However, the timing of a second-look procedure is unclear particularly in a patient with anastomosis.