METHODS, MATHEMATICAL MODELS, DATA QUALITY ASSESSMENT AND RESULT INTERPRETATION: SOLUTIONS DEVELOPED IN THE IFEDH FRAMEWORK
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The IFEDH project focuses on advanced health technology assessment (HTA) using innovative modeling techniques and interdisciplinary approaches to decision-making in Austria. It emphasizes the integration of data quality assessment, modular modeling structures, and collaboration among experts in various fields to support medical technology decisions. Key applications include agent-based modeling for seasonal influenza, economic modeling for HPV vaccination, and screening programs for abdominal aortic aneurysm.
METHODS, MATHEMATICAL MODELS, DATA QUALITY ASSESSMENT AND RESULT INTERPRETATION: SOLUTIONS DEVELOPED IN THE IFEDH FRAMEWORK
- 1. METHODS, MATHEMATICAL MODELS, DATA QUALITY ASSESSMENT AND RESULT INTERPRETATION: SOLUTIONS DEVELOPED IN THE IFEDH FRAMEWORK G. Zauner dwh Simulation Services Vienna , Austria
- 2. IFEDH – Framework: Basics 1. Decisions have to be made in Austria 2. Advanced data structures, HTA methods and new modeling techniques 3. Interdisciplinary project tasks 4. „Good Practice“ guidelines, limited development duration The IFEDH project
- 3. The IFEDH Network IFEDH CUSTOMER Network Decision Makers Services Provider Pharmaceutical Ministry Industry Informations for Generating Evidence Provinces Based Decision on Medical Technology Basis of Models for Social Security Possible Strategies Medical Provider
- 5. IFEDH – Framework: Partner • Modeling experts (theoretical development and practical solutions) • HTA experts (Main Association of Austrian Health Security Services, Ludwig Boltzmann Institute - Health Technology Assessment) • Data structure and DQA experts • Statisticians • Web developer and programmer • Centre for Virtual Reality and Visualization
- 6. IFEDH – Framework: Structure 1. State of the Art detection and guideance for practical use in: I. Modeling II. HTA Techniques III. Visualization IV. Data Sources and Data Quality Assessment V. Validatation and Verification 2. Modular and hybrid modeling technique development 3. Data source evaluation and HTA-manager tool 4. Proof of concept
- 7. IFEDH – Framework: Structure Data structures HTA techniques Validation Modular models Verification HTA question Result Hybrid models Interpretation DQA Visualization
- 8. IFEDH – Framework: Structure
- 9. IFEDH – Framework: Proof of Concept 1. Seasonal influenza epidemics Agent based model / modular structure 2. Human papillomavirus (HPV) vaccination and cancer treatment Economic Model ODE model + Markov structure Social Interaction Model Disease Model 3. Abdominal aortic aneurysm (AAA) screening bottum-up modeling, cost module Population Model
- 10. Including modeling techniques in HTA Feedback to data structure Feedback to model pool internal data Pool of Hybrid Problem Methods decom- Evaluation class (HVB, clinical position Insigths for definition trials, …) - AB - SD, ODEs data economical model structure - couplings point of view external com- external -… model data parison evaluation demand Feedback to data structure
- 11. Conclusion An interdiciplinary process for model based HTA is under development Modeling and Simulation plays a key role in decision making in advanced HTA questions Modular structures allow faster decision support and guarantee approved model structures/model assumptions Knowledge combination of different domains is an import basis for successful solution of socio-economic questions in HTA and EBM
- 12. Thank you very much!