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Germs:  The Good, the Bad, and the Ugly Clara Pelfrey, Ph.D. Cleveland Clinic & Case Western Reserve University
“ Microorganisms” are tiny creatures that cannot be seen without a microscope They are everywhere – air, water, food, and  everything  you touch Bacteria, viruses, fungi, protozoa What are germs?
Some common conditions caused by germs Condition Kind of Germ Common Symptoms Athelete’s Foot Fungus Red, scaly, itchy rash on feet Chickenpox Virus Fever; headache; red, pimple-like rash Common Cold Virus Sore throat; runny or stuffed-up nose; coughing; sneezing Ear infection Bacteria Pain and/or swelling in ear; fever Flu Virus Fever; headache; sore throat; coughing; muscle aches Strep Throat Bacteria Fever; sore throat; headache; swollen tonsils or yellow patches at back of throat
Before people knew about viruses and other germs, they had some strange ideas about what caused illnesses.  Hippocrates  thought that colds were caused by  waste matter in the brain .  When the waste overflowed, he said, it ran out the nose.
In the Middle Ages, people thought illnesses were due to  demons . They said that sneezing was very dangerous because a person’s soul might be sneezed out, and a demon could sneak in and replace it.  Saying  “God bless you!”  when people sneezed was a way to protect them from demons.
Bacteria are single cell organisms.  Their cells are  Prokaryotic , meaning that they lack a membrane-bound nucleus and many of the cell parts of Eukaryotes. Some of their parts:
Microbe talk
Three general shapes of bacteria: Round (coccus,  plr. cocci) Rod  (bacillus,  plr. bacilli) Spiral (spirillum, plr. spirilla)  Example: Staphylococcus epidermidis Example:  Escherichia coli Example: Treponema pallidum                                           
Microbe talk
Computer-generated video showing the motions of an E. coli bacterium
Types of bacteria
“ Streak plate” on a petri dish to isolate bacteria
Bacterial colonies on agar
Label agar plates on the  BOTTOM … to prevent condensation
Enterotubes help hospitals identify bacteria
“ The Good, the Bad  and the Ugly” BAD BACTERIA Cause disease Bad breath Body odor Spoiled food GOOD BACTERIA Make vitamins Aid digestion Make food Clean pollution Battle bad bacteria
The “Good guys” See if you can figure them out! Game show quiz:
BEER YEAST
Blue cheese Blue mold
Champagne Yeast
Compost Soil Bacteria
Oil spill These "oil-eating" bacteria are shown swimming around large droplets of oil.
Oenococcus   Oeni  -lactic acid bacterium Wine
Yogurt “ Live active cultures”  Lactobacillus acidophilus
Penicillin Penicillium
Penicillium mold inhibiting bacterial growth Mold Bacteria Zone of inhibition
Bread Baker’s yeast
Sausage & Salami Soy sauce Pickles
The “Bad” guys
Click on the picture to go to a web video on proper sneezing technique When you sneeze, air explodes out of your lungs at a speed of 100 miles per hour.  The air in a cough travels at 500 mph!
To cover or not cover  your mouth? ANSWER : Cover your mouth when you cough THEN  : wash your hands BETTER  : cough or sneeze into a tissue or your sleeve
The “Ugly”
Bacteria growing on your teeth can cause tooth decay
Bacterial colonies
Moldy bread!
Relative size of a bacterium, compared to a virus
Play HOW BIG?   MOVIE
What are viruses? Extremely small and simple life-forms, made of a chromosome surrounded by a protein shell. Live inside the cells of animals, plants and bacteria and often cause disease.  Reproduces by inserting its genes into the cells of other life-forms. As those cells divide, so does the virus. Too small to be seen even with microscopes. Cannot multiply or produce disease outside of a living cell.
Microbe talk
DNA Viruses
RNA Viruses
AIDS Virus structure
AIDS Virus particles
Louis Pasteur Disproved “Spontaneous  Generation” Germ theory of disease Pasteurization Rabies vaccine Anthrax vaccine
Pasteur gives the first Rabies vaccine
Benjamin Franklin
Conclusions Germs are everywhere! Germs include bacteria, viruses and fungi Some germs are useful: “The Good Guys” Avoid spreading infections by sneezing/coughing into your sleeve The most important thing you can do is:  WASH YOUR HANDS !

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Microbe talk

  • 1. Germs: The Good, the Bad, and the Ugly Clara Pelfrey, Ph.D. Cleveland Clinic & Case Western Reserve University
  • 2. “ Microorganisms” are tiny creatures that cannot be seen without a microscope They are everywhere – air, water, food, and everything you touch Bacteria, viruses, fungi, protozoa What are germs?
  • 3. Some common conditions caused by germs Condition Kind of Germ Common Symptoms Athelete’s Foot Fungus Red, scaly, itchy rash on feet Chickenpox Virus Fever; headache; red, pimple-like rash Common Cold Virus Sore throat; runny or stuffed-up nose; coughing; sneezing Ear infection Bacteria Pain and/or swelling in ear; fever Flu Virus Fever; headache; sore throat; coughing; muscle aches Strep Throat Bacteria Fever; sore throat; headache; swollen tonsils or yellow patches at back of throat
  • 4. Before people knew about viruses and other germs, they had some strange ideas about what caused illnesses. Hippocrates thought that colds were caused by waste matter in the brain . When the waste overflowed, he said, it ran out the nose.
  • 5. In the Middle Ages, people thought illnesses were due to demons . They said that sneezing was very dangerous because a person’s soul might be sneezed out, and a demon could sneak in and replace it. Saying “God bless you!” when people sneezed was a way to protect them from demons.
  • 6. Bacteria are single cell organisms. Their cells are Prokaryotic , meaning that they lack a membrane-bound nucleus and many of the cell parts of Eukaryotes. Some of their parts:
  • 8. Three general shapes of bacteria: Round (coccus, plr. cocci) Rod (bacillus, plr. bacilli) Spiral (spirillum, plr. spirilla) Example: Staphylococcus epidermidis Example: Escherichia coli Example: Treponema pallidum                                        
  • 10. Computer-generated video showing the motions of an E. coli bacterium
  • 12. “ Streak plate” on a petri dish to isolate bacteria
  • 14. Label agar plates on the BOTTOM … to prevent condensation
  • 15. Enterotubes help hospitals identify bacteria
  • 16. “ The Good, the Bad and the Ugly” BAD BACTERIA Cause disease Bad breath Body odor Spoiled food GOOD BACTERIA Make vitamins Aid digestion Make food Clean pollution Battle bad bacteria
  • 17. The “Good guys” See if you can figure them out! Game show quiz:
  • 22. Oil spill These "oil-eating" bacteria are shown swimming around large droplets of oil.
  • 23. Oenococcus Oeni -lactic acid bacterium Wine
  • 24. Yogurt “ Live active cultures” Lactobacillus acidophilus
  • 26. Penicillium mold inhibiting bacterial growth Mold Bacteria Zone of inhibition
  • 28. Sausage & Salami Soy sauce Pickles
  • 30. Click on the picture to go to a web video on proper sneezing technique When you sneeze, air explodes out of your lungs at a speed of 100 miles per hour. The air in a cough travels at 500 mph!
  • 31. To cover or not cover your mouth? ANSWER : Cover your mouth when you cough THEN : wash your hands BETTER : cough or sneeze into a tissue or your sleeve
  • 33. Bacteria growing on your teeth can cause tooth decay
  • 36. Relative size of a bacterium, compared to a virus
  • 37. Play HOW BIG? MOVIE
  • 38. What are viruses? Extremely small and simple life-forms, made of a chromosome surrounded by a protein shell. Live inside the cells of animals, plants and bacteria and often cause disease. Reproduces by inserting its genes into the cells of other life-forms. As those cells divide, so does the virus. Too small to be seen even with microscopes. Cannot multiply or produce disease outside of a living cell.
  • 44. Louis Pasteur Disproved “Spontaneous Generation” Germ theory of disease Pasteurization Rabies vaccine Anthrax vaccine
  • 45. Pasteur gives the first Rabies vaccine
  • 47. Conclusions Germs are everywhere! Germs include bacteria, viruses and fungi Some germs are useful: “The Good Guys” Avoid spreading infections by sneezing/coughing into your sleeve The most important thing you can do is: WASH YOUR HANDS !