Mitodiseaseppt
- 2. What are mitochondria ? What’s the mitochondria disease? What causes mitochondria disease? What Symptoms could result from abnormal mitochondria? What should we do to conquer this disease? Parkinson's disease —The most popular disease caused by disorder of mitochondria. CatalogCatalog
- 3. A mitochondrion (singular of mitochondria) is part of every cell in the body that contains genetic material. Mitochondria are responsible for processing oxygen and converting substances from the foods we eat into energy for essential cell functions. Mitochondria produce energy in the form of ATP, which is then transported to the cytoplasm of a cell for use in numerous cell functions. MitochondriaMitochondria
- 4. Mitochondria are responsible for producing most of the energy that's needed for our cells to function. In fact, they provide such an important source of energy that a typical human cell contains hundreds of them. A mitochondrial disease can shut down some or all the mitochondria, cutting off this essential energy supply. Mitochondrial DNA (mtDNA) mutations is thought to be the reason which cause mitochondria disease Mitochondria DiseasesMitochondria Diseases
- 5. Symptoms of abnormal mitochondrialSymptoms of abnormal mitochondrial Poor growth Loss of muscle coordination, muscle weakness Visual or hearing problems Developmental delays, learning disabilities Mental retardation Heart, liver, or kidney disease Gastrointestinal disorders severe constipation
- 6. Symptoms of abnormal mitochondrialSymptoms of abnormal mitochondrial Respiratory disorders Diabetes （糖尿病） Increased risk of infection Neurological problems, seizures Thyroid dysfunction （甲状腺功能紊乱） Dementia( 痴呆 )
- 7. Causes of mitochondrial diseaseCauses of mitochondrial disease DNA (DNA contained in the nucleus of the cell) inheritance MtDNA (DNA contained in the mitochondria) inheritance Combination of mtDNA and nDNA defects Random occurrences
- 8. TreatmentTreatment Certain vitamin and enzyme therapies Diet therapy Antioxidant treatments
- 9. Parkinson’s Disease (PD)Parkinson’s Disease (PD) Parkinson's disease is a disorder of the brain characterized by shaking (tremor) and difficulty with walking, movement, and coordination. The disease is associated with damage to a part of the brain that is involved with movement.
- 10. Causes of PDCauses of PD Parkinson‘s disease is caused by progressive deterioration of the nerve cells of the part of the brain that controls muscle movement. Dopamine( 多巴胺 ), which is one of the substances used by cells to transmit impulses, is normally produced in this area. Deterioration of this area of the brain reduces the amount of dopamine available to the body. Insufficient dopamine disturbs the balance between dopamine and other transmitters, such as acetylcholine( 乙酰胆碱 ). Without dopamine, the nerve cells cannot properly transmit messages, and this results in the loss of muscle function.
- 11. communication network in nervous system
- 12. Healthy balance of dopamine and acetylcholine Imbalance of dopamine and acetylcholine in Parkinson's disease.
- 13. signs and symptoms of Parkinson's diseasesigns and symptoms of Parkinson's disease Tremors Slowed motion (bradykinesia). Rigid muscles Loss of automatic movements Impaired speech Difficulty swallowing Dementia
- 14. TreatmentTreatment Drug treatmentDrug treatment The most successful treatment that we can reduce our pain caused by Parkinson’s disease. Surgical TreatmentSurgical Treatment Recent advances in neuroimaging and stereotactic surgery have led to a renaissance in neurosurgery for Parkinson’s disease.
- 15. I believe that we can finally conquer our diseases caused by all abnormal organs , and make our life long!
Editor's Notes
- #6: The types of mitochondrial diseases are categorized according to the organ systems affected and symptoms present. Mitochondrial diseases might affect the cells of the brain, nerves (including the nerves to the stomach and intestines), muscles, kidneys, heart, liver, eyes, ears, or pancreas. In some patients, only one organ is affected, while in other patients all the organs are involved. Depending on how severe the mitochondrial disorder is, the illness can range in severity from mild to fatal. Depending on which cells of the body are affected, symptoms might include:
- #8: For many patients, mitochondrial disease is an inherited condition that runs in families (genetic). An uncertain percentage of patients acquire symptoms due to other factors, including mitochondrial toxins. The types of mitochondrial disease inheritance include
- #9: There are no cures for mitochondrial diseases, but treatment can help reduce symptoms, or delay or prevent the progression of the disease.