The guided tour summarizes key artworks in the Vatican Museum, including Bernini's Baldacchino in St. Peter's Basilica, Michelangelo's Pieta sculpture, his paintings on the Sistine Chapel ceiling including The Creation of Adam, Raphael's School of Athens fresco, and Bernini's colonnades in St. Peter's Square. The tour provides details on the artists, dates, mediums, meanings, and highlights what the narrator finds most impressive about each work.