This document provides an introduction and overview for establishing monitoring and evaluation (M&E) systems for National AIDS Councils (NACs) in sub-Saharan Africa. It outlines key lessons learned around M&E, including the importance of simple and standardized systems, internal self-assessment combined with external verification, and contracting a single entity to manage both financial and programmatic M&E. The document presents a framework for NAC M&E and emphasizes building participatory M&E systems before grants are awarded and ensuring long-term, comprehensive funding for all major M&E components. The manual aims to provide practical tools and guidance to help NACs and their partners design and implement effective M&E.