Mood disorders are mental health conditions characterized by significant and chronic disruptions in mood, leading to impaired functioning. Major depression is the most common form, marked by prolonged periods of sadness and loss of interest, affecting approximately 12 million people annually, with women being twice as likely to be diagnosed. Treatment involves ensuring patient safety, using pharmacotherapy such as antidepressants, and providing cognitive therapy and nursing interventions to support daily functioning and address suicidal ideation.