This document provides national guidelines on rabies prophylaxis in India. It outlines recommendations for post-exposure prophylaxis following animal bites, including immediate wound cleansing with soap and water, application of a viricidal agent, infiltration of rabies immunoglobulin for category III exposures, and vaccination. It emphasizes starting prophylaxis as early as possible, and describes management approaches based on the category of exposure and vaccination status of the biting animal. Proper wound management and vaccination are essential to prevent rabies, along with annual vaccination of pets.