The document proposes methods for primary user detection in cognitive radio that are robust to noise uncertainty (NU). It derives closed-form probability density functions of the signal and energy statistics under NU, allowing an optimal detector to be employed. It models NU using a log-normal distribution and evaluates detection performance for the energy detector. The proposed detector that accounts for the NU distribution can avoid the "SNR wall" phenomenon and achieve better detection performance than a worst-case detector that is not informed by the NU distribution.