Dr. Jim Nolan from University Hospital of North Staffordshire presented at the Rencontres Interventionnelles conference in Prague, Czech Republic in 2011. The presentation discussed challenging radial artery cases and how to treat them. Some of the key issues discussed included the influence of forearm arterial anatomy on outcomes, subclavian issues, backup strategies, and challenging cases. Dr. Nolan advocates acquiring an arm angiogram after sheath insertion to plan the optimal procedure and reduce risks. He discusses different anatomical variations like high bifurcations and loops, and their increased risks. Strategies presented to deal with variations included minimizing catheter size and exchanges, considering 5F guiding catheters, and sheathless guides. Rare variations like retroes