This document summarizes a study that investigates nonlinear control approaches for an air-handling unit (AHU). A nonlinear multi-input multi-output dynamic model of an AHU is developed. Both indoor temperature and relative humidity are controlled by manipulating air and cold water flow rates. Two nonlinear control approaches, gain scheduling and feedback linearization, are designed and compared. Results show feedback linearization achieves faster tracking of setpoints but with more overshoot, while gain scheduling has less oscillation in control inputs and likely lower energy use. Feedback linearization is also more robust to model parameter uncertainty.